SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r9g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		4 / 4 SER A 332
LEU A 411
TYR A 399
GLY A 290
 None
 1.37A 1liiA-2r9gA:
undetectable		 1liiA-2r9gA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		3 / 3 VAL A 320
VAL A 299
ASP A 271
 None
 0.78A 2fumD-2r9gA:
undetectable		 2fumD-2r9gA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		3 / 3 ARG A 278
VAL A 320
THR A 298
 None
 0.80A 2nmzA-2r9gA:
undetectable		 2nmzA-2r9gA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		3 / 3 ARG A 278
VAL A 320
THR A 298
 None
 0.78A 2nnkA-2r9gA:
undetectable		 2nnkA-2r9gA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		3 / 3 ARG A 278
VAL A 320
THR A 298
 None
 0.69A 3k4vA-2r9gA:
undetectable		 3k4vA-2r9gA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		3 / 3 ARG A 278
VAL A 320
THR A 298
 None
 0.72A 3k4vD-2r9gA:
undetectable		 3k4vD-2r9gA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		3 / 3 ARG A 278
VAL A 320
THR A 298
 None
 0.66A 3ndtA-2r9gA:
undetectable		 3ndtA-2r9gA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		3 / 3 ARG A 278
VAL A 320
THR A 298
 None
 0.69A 3nduD-2r9gA:
undetectable		 3nduD-2r9gA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		3 / 3 ARG A 278
VAL A 320
THR A 298
 None
 0.73A 3pwrA-2r9gA:
undetectable		 3pwrA-2r9gA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		3 / 3 ARG A 278
VAL A 320
THR A 298
 None
 0.70A 3tl9A-2r9gA:
undetectable		 3tl9A-2r9gA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		5 / 11 ILE A 275
LEU A 310
ALA A 305
ALA A 304
VAL A 320
 None
 1.17A 4h1nA-2r9gA:
undetectable		 4h1nA-2r9gA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		4 / 7 LEU A 279
THR A 298
ALA A 301
ILE A 315
 None
 0.71A 4yjiA-2r9gA:
undetectable		 4yjiA-2r9gA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		3 / 3 ASN A 291
ALA A 293
ARG A 297
 None
 0.26A 5cvtB-2r9gA:
undetectable		 5cvtB-2r9gA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		3 / 3 TYR A 334
ALA A 340
LEU A 341
 None
 0.63A 6ag0C-2r9gA:
undetectable		 6ag0C-2r9gA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2r9g AAA ATPASE, CENTRAL
REGION
(Enterococcus
faecium) 		3 / 3 TYR A 284
PRO A 292
LEU A 289
 None
 0.79A 6beoA-2r9gA:
undetectable		 6beoA-2r9gA:
7.77