SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r9h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 181
ALA A 182
ILE A 109
PRO A 206
ILE A 200
 None
None
CL  A   2 ( 4.9A)
None
None
 0.95A 1c6zA-2r9hA:
undetectable		 1c6zA-2r9hA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 181
ALA A 182
ILE A 109
PRO A 206
ILE A 200
 None
None
CL  A   2 ( 4.9A)
None
None
 1.02A 1c6zB-2r9hA:
undetectable		 1c6zB-2r9hA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 9 THR A 138
GLY A 135
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.25A 1jhoA-2r9hA:
undetectable		 1jhoA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 8 THR A 138
GLY A 135
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.26A 1jhqA-2r9hA:
undetectable		 1jhqA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 9 THR A 138
GLY A 135
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.26A 1jhrA-2r9hA:
undetectable		 1jhrA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 8 THR A 138
GLY A 134
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.13A 1jhvA-2r9hA:
undetectable		 1jhvA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 8 THR A 138
GLY A 135
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.27A 1jhvA-2r9hA:
undetectable		 1jhvA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 9 THR A 138
GLY A 135
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.24A 1jhyA-2r9hA:
undetectable		 1jhyA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 9 THR A 138
GLY A 135
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.28A 1l4nA-2r9hA:
undetectable		 1l4nA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 9 THR A 138
GLY A 135
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.26A 1l5kA-2r9hA:
undetectable		 1l5kA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 9 THR A 138
GLY A 135
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.26A 1l5lA-2r9hA:
undetectable		 1l5lA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 9 THR A 138
GLY A 135
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.27A 1l5mA-2r9hA:
undetectable		 1l5mA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A  93
GLY A 134
GLY A 135
GLY A 295
ASN A 287
 None
 0.92A 1n2xB-2r9hA:
undetectable		 1n2xB-2r9hA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 8 GLY A 303
GLY A 300
GLY A 299
LEU A 301
SER A 313
 None
 1.19A 1qzzA-2r9hA:
undetectable		 1qzzA-2r9hA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		6 / 10 LEU A 333
ALA A 311
GLY A 315
GLY A 316
ILE A 320
ILE A 336
 None
 1.26A 1sdvA-2r9hA:
undetectable		 1sdvA-2r9hA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 8 ALA A 370
PHE A 371
ALA A 375
LEU A 254
 None
 0.42A 2bxmA-2r9hA:
1.3		 2bxmA-2r9hA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 ILE A 197
ILE A 200
ALA A 183
ALA A  39
ILE A  35
 None
 0.99A 2h79A-2r9hA:
undetectable		 2h79A-2r9hA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 ILE A 268
GLY A 440
THR A 439
ASN A 270
PRO A 443
 None
 1.03A 2y7hB-2r9hA:
undetectable		 2y7hB-2r9hA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 ILE A 268
GLY A 440
THR A 439
ASN A 270
PRO A 443
 None
 1.04A 2y7hC-2r9hA:
undetectable		 2y7hC-2r9hA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 7 ILE A 356
ILE A 320
LEU A 444
LEU A 411
 CL  A   2 ( 4.9A)
None
None
None
 0.78A 3adxA-2r9hA:
undetectable		 3adxA-2r9hA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 9 VAL A  57
GLY A 135
PRO A 150
THR A 151
LYS A  55
 None
 1.40A 3bjwG-2r9hA:
undetectable		 3bjwG-2r9hA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		3 / 3 GLY A 300
GLY A 142
GLY A 303
 None
 0.37A 3bogC-2r9hA:
undetectable		 3bogC-2r9hA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 4 SER A  86
GLY A 300
GLY A 142
GLY A 306
 None
 0.82A 3bogB-2r9hA:
undetectable
3bogD-2r9hA:
undetectable		 3bogB-2r9hA:
undetectable
3bogD-2r9hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 4 SER A 225
GLY A  47
GLY A 221
GLY A 181
 None
 0.57A 3bogB-2r9hA:
undetectable
3bogD-2r9hA:
undetectable		 3bogB-2r9hA:
undetectable
3bogD-2r9hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 PHE A 190
LEU A 411
ALA A 189
THR A 151
VAL A 152
 None
 1.17A 3cwkA-2r9hA:
undetectable		 3cwkA-2r9hA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 351
GLY A 149
GLY A 108
GLY A 105
PHE A 190
 None
CL  A   2 ( 4.2A)
CL  A   1 ( 4.2A)
None
None
 0.85A 3eluA-2r9hA:
undetectable		 3eluA-2r9hA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 351
GLY A 149
GLY A 108
GLY A 105
PHE A 190
 None
CL  A   2 ( 4.2A)
CL  A   1 ( 4.2A)
None
None
 0.88A 3elwA-2r9hA:
undetectable		 3elwA-2r9hA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 ASN A 157
GLY A 155
VAL A  42
MET A 204
LEU A 116
 None
 1.23A 3h52A-2r9hA:
undetectable		 3h52A-2r9hA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 10 MET A 415
LEU A 411
ARG A 147
PRO A 321
GLY A 316
 None
 1.13A 3hcpB-2r9hA:
0.2		 3hcpB-2r9hA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 ALA A 115
ALA A 104
ALA A 182
VAL A 152
PRO A 150
 None
 1.10A 3jb3A-2r9hA:
undetectable		 3jb3A-2r9hA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 7 ILE A 402
LEU A 411
THR A 151
THR A 365
 None
 1.17A 3nxuA-2r9hA:
undetectable		 3nxuA-2r9hA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 9 GLY A 221
ALA A  39
ILE A  35
GLY A 159
ILE A 158
 None
 0.97A 3ogpA-2r9hA:
undetectable		 3ogpA-2r9hA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 9 GLY A 221
ALA A  39
ILE A  35
GLY A 159
ILE A 158
 None
 1.04A 3ogpB-2r9hA:
undetectable		 3ogpB-2r9hA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 196
GLY A 408
GLU A 203
VAL A 222
ILE A 197
 None
 0.89A 3p97C-2r9hA:
undetectable		 3p97C-2r9hA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 196
ALA A 183
VAL A  42
ILE A 223
ILE A 215
 None
 1.03A 3s56A-2r9hA:
undetectable		 3s56A-2r9hA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 181
ALA A 182
ILE A 109
PRO A 206
ILE A 200
 None
None
CL  A   2 ( 4.9A)
None
None
 0.96A 3tkgB-2r9hA:
undetectable		 3tkgB-2r9hA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 11 GLY A 196
ALA A 183
VAL A  42
GLY A  43
ILE A 223
 None
 0.83A 3ufnA-2r9hA:
undetectable		 3ufnA-2r9hA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 6 MET A 143
LEU A 145
GLN A 153
PRO A 150
 None
 1.45A 3vkxA-2r9hA:
undetectable		 3vkxA-2r9hA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 ILE A 239
LEU A 145
ALA A 189
PHE A 190
VAL A 152
 None
 0.97A 3w67C-2r9hA:
undetectable		 3w67C-2r9hA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 8 LEU A 194
ILE A 197
GLY A 221
ILE A 223
 None
 0.75A 3wxoA-2r9hA:
0.6		 3wxoA-2r9hA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 VAL A  57
VAL A 152
ILE A 109
TYR A 445
LEU A 139
 None
None
CL  A   2 ( 4.9A)
CL  A   2 ( 4.8A)
None
 1.25A 4a84A-2r9hA:
undetectable		 4a84A-2r9hA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 VAL A 218
ILE A 215
ILE A 109
GLU A 203
HIS A 175
 None
None
CL  A   2 ( 4.9A)
None
None
 1.28A 4a97B-2r9hA:
2.3
4a97C-2r9hA:
2.3		 4a97B-2r9hA:
21.59
4a97C-2r9hA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 196
GLY A 408
GLU A 203
VAL A 222
ILE A 197
 None
 0.86A 4ctjA-2r9hA:
undetectable		 4ctjA-2r9hA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 196
GLY A 408
GLU A 203
VAL A 222
ILE A 197
 None
 0.92A 4ctjC-2r9hA:
undetectable		 4ctjC-2r9hA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 5 LEU A 398
ILE A 109
ALA A 404
PHE A 199
 None
CL  A   2 ( 4.9A)
None
None
 1.10A 4dc3B-2r9hA:
undetectable		 4dc3B-2r9hA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 6 ALA A  82
ALA A  67
LEU A  78
THR A  71
 None
 1.11A 4dtzB-2r9hA:
undetectable		 4dtzB-2r9hA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 7 ILE A 402
LEU A 444
PHE A 348
GLY A 106
 None
None
None
CL  A   1 ( 3.8A)
 0.91A 4hajA-2r9hA:
undetectable		 4hajA-2r9hA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 8 ILE A 402
LEU A 444
PHE A 348
GLY A 106
 None
None
None
CL  A   1 ( 3.8A)
 0.82A 4hb8A-2r9hA:
undetectable		 4hb8A-2r9hA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 7 ILE A 402
LEU A 444
PHE A 348
GLY A 106
 None
None
None
CL  A   1 ( 3.8A)
 0.89A 4hc3A-2r9hA:
undetectable		 4hc3A-2r9hA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 9 THR A 138
GLY A 135
GLY A 355
LEU A 145
GLY A 106
 None
None
CL  A   2 ( 3.0A)
None
CL  A   1 ( 3.8A)
 1.24A 4kqiA-2r9hA:
undetectable		 4kqiA-2r9hA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 181
ALA A 182
ILE A 109
PRO A 206
ILE A 200
 None
None
CL  A   2 ( 4.9A)
None
None
 1.04A 4njvD-2r9hA:
undetectable		 4njvD-2r9hA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		6 / 11 GLY A 105
ALA A 104
ILE A 154
THR A 151
GLY A 149
ILE A 109
 None
None
None
None
CL  A   2 ( 4.2A)
CL  A   2 ( 4.9A)
 1.34A 4qgiA-2r9hA:
undetectable		 4qgiA-2r9hA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 5 GLY A 263
ALA A 432
GLY A 266
PRO A 267
 None
 0.90A 4u9uA-2r9hA:
undetectable		 4u9uA-2r9hA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 5 GLY A 263
ALA A 432
GLY A 266
PRO A 267
 None
 0.93A 4u9uB-2r9hA:
undetectable		 4u9uB-2r9hA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 5 LEU A 384
TYR A 255
LEU A 254
THR A 388
 None
 1.20A 4wozF-2r9hA:
undetectable
4wozH-2r9hA:
undetectable		 4wozF-2r9hA:
19.33
4wozH-2r9hA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 8 ALA A 184
VAL A  42
GLY A 185
ALA A 188
GLY A  47
 None
 1.29A 4zjzB-2r9hA:
undetectable		 4zjzB-2r9hA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 7 GLY A 185
SER A 225
GLY A  47
ALA A 189
 None
 0.95A 5e26A-2r9hA:
undetectable
5e26B-2r9hA:
undetectable		 5e26A-2r9hA:
24.62
5e26B-2r9hA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 196
GLY A 408
GLU A 203
VAL A 222
ILE A 197
 None
 0.84A 5ehiA-2r9hA:
undetectable		 5ehiA-2r9hA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 196
GLY A 408
GLU A 203
VAL A 222
ILE A 197
 None
 0.88A 5eiwA-2r9hA:
undetectable		 5eiwA-2r9hA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 196
GLY A 408
GLU A 203
VAL A 222
ILE A 197
 None
 0.87A 5ekxB-2r9hA:
undetectable		 5ekxB-2r9hA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		3 / 3 GLY A 315
GLY A 314
GLN A  61
 None
 0.47A 5imsA-2r9hA:
undetectable		 5imsA-2r9hA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 ILE A 410
THR A 226
ALA A 404
ILE A 215
PHE A 219
 None
 1.13A 5iwuA-2r9hA:
undetectable		 5iwuA-2r9hA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		6 / 12 GLY A 105
ALA A 104
ILE A 154
GLY A 149
ILE A 109
VAL A 122
 None
None
None
CL  A   2 ( 4.2A)
CL  A   2 ( 4.9A)
None
 1.49A 5kqxA-2r9hA:
undetectable		 5kqxA-2r9hA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 PHE A 348
GLY A 354
LYS A 131
GLY A 355
GLU A 113
 None
None
None
CL  A   2 ( 3.0A)
None
 1.22A 5ul4A-2r9hA:
undetectable		 5ul4A-2r9hA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 351
GLY A 149
GLY A 108
GLY A 105
PHE A 190
 None
CL  A   2 ( 4.2A)
CL  A   1 ( 4.2A)
None
None
 0.84A 5vimA-2r9hA:
undetectable		 5vimA-2r9hA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 351
GLY A 149
GLY A 108
GLY A 105
PHE A 190
 None
CL  A   2 ( 4.2A)
CL  A   1 ( 4.2A)
None
None
 0.83A 5vimB-2r9hA:
undetectable		 5vimB-2r9hA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 9 THR A 180
GLY A 181
ALA A 184
GLY A 159
LEU A 177
 None
 0.91A 5vw4A-2r9hA:
undetectable		 5vw4A-2r9hA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		4 / 8 THR A 180
GLY A 181
ALA A 184
GLY A 159
 None
 0.61A 5vw9A-2r9hA:
undetectable		 5vw9A-2r9hA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 LEU A 421
TYR A 255
ALA A 392
GLU A 377
PHE A 379
 None
 1.23A 5x6yC-2r9hA:
undetectable		 5x6yC-2r9hA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 196
GLY A 181
GLY A 185
ILE A 112
ALA A 179
 None
 1.21A 5x7fA-2r9hA:
undetectable		 5x7fA-2r9hA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 364
GLY A 395
THR A 344
LEU A 345
PHE A 269
 None
 1.18A 5ybbA-2r9hA:
undetectable		 5ybbA-2r9hA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 11 GLU A 113
GLY A 181
ALA A 182
ALA A 179
ARG A 160
 None
 1.17A 5yk2A-2r9hA:
1.1		 5yk2A-2r9hA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 7 GLY A 142
GLY A 141
GLY A 137
GLY A 134
GLY A 135
 None
 0.75A 6ag0A-2r9hA:
undetectable		 6ag0A-2r9hA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 259
GLY A 429
ALA A 399
ILE A 261
LEU A 258
 None
 1.13A 6b3aA-2r9hA:
undetectable		 6b3aA-2r9hA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 259
GLY A 429
ALA A 399
ILE A 261
LEU A 258
 None
 1.09A 6b3bA-2r9hA:
undetectable		 6b3bA-2r9hA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 355
GLY A 354
GLN A 277
VAL A  97
GLN A 153
 CL  A   2 ( 3.0A)
None
None
None
None
 1.18A 6gneA-2r9hA:
undetectable		 6gneA-2r9hA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA
(Escherichia
coli) 		5 / 12 GLY A 355
GLY A 354
GLN A 277
VAL A  97
GLN A 153
 CL  A   2 ( 3.0A)
None
None
None
None
 1.15A 6gneB-2r9hA:
undetectable		 6gneB-2r9hA:
22.70