SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r9l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  43
ASP A 282
LEU A 283
LEU A 284
 None
 1.08A 1e7cA-2r9lA:
undetectable		 1e7cA-2r9lA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A 237
PRO A 240
TYR A 180
 EDO  A 295 (-4.1A)
None
None
 0.83A 2dxrA-2r9lA:
undetectable		 2dxrA-2r9lA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 MET A  40
LEU A  99
ILE A 238
ALA A 239
TYR A  33
 None
None
EDO  A 295 (-4.1A)
None
None
 1.17A 2japA-2r9lA:
undetectable		 2japA-2r9lA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 MET A  40
LEU A  99
ILE A 238
ALA A 239
TYR A  33
 None
None
EDO  A 295 (-4.1A)
None
None
 1.18A 2japB-2r9lA:
undetectable		 2japB-2r9lA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 MET A  40
LEU A  99
ILE A 238
ALA A 239
TYR A  33
 None
None
EDO  A 295 (-4.1A)
None
None
 1.20A 2japC-2r9lA:
undetectable		 2japC-2r9lA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 MET A  40
LEU A  99
ILE A 238
ALA A 239
TYR A  33
 None
None
EDO  A 295 (-4.1A)
None
None
 1.17A 2japD-2r9lA:
undetectable		 2japD-2r9lA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 149
ALA A 153
TRP A 257
LEU A 179
 None
 1.17A 2oaxA-2r9lA:
undetectable		 2oaxA-2r9lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 231
LEU A 195
ALA A 196
LEU A 179
THR A 237
 None
PEG  A 297 ( 3.9A)
None
None
EDO  A 295 (-4.1A)
 1.20A 2oaxF-2r9lA:
undetectable		 2oaxF-2r9lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 258
ASP A 261
GLU A 259
ARG A 276
 None
 1.33A 2ouzA-2r9lA:
undetectable		 2ouzA-2r9lA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 243
ALA A 103
LEU A  99
ALA A  34
 None
 0.96A 2vcvB-2r9lA:
undetectable		 2vcvB-2r9lA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 243
ALA A 103
LEU A  99
ALA A  34
 None
 0.97A 2vcvK-2r9lA:
undetectable		 2vcvK-2r9lA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 244
ARG A  47
ARG A 133
HIS A 178
 EDO  A 296 (-4.4A)
None
None
None
 1.44A 2vxaA-2r9lA:
undetectable
2vxaC-2r9lA:
undetectable
2vxaE-2r9lA:
undetectable		 2vxaA-2r9lA:
13.19
2vxaC-2r9lA:
13.19
2vxaE-2r9lA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ARG A  47
ARG A 244
ARG A 133
HIS A 178
 None
EDO  A 296 (-4.4A)
None
None
 1.45A 2vxaA-2r9lA:
undetectable
2vxaB-2r9lA:
undetectable
2vxaK-2r9lA:
undetectable		 2vxaA-2r9lA:
13.19
2vxaB-2r9lA:
13.19
2vxaK-2r9lA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ARG A  47
ARG A 244
ARG A 133
HIS A 178
 None
EDO  A 296 (-4.4A)
None
None
 1.46A 2vxaB-2r9lA:
undetectable
2vxaC-2r9lA:
undetectable
2vxaG-2r9lA:
undetectable		 2vxaB-2r9lA:
13.19
2vxaC-2r9lA:
13.19
2vxaG-2r9lA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ARG A  47
ARG A 244
ARG A 133
HIS A 178
 None
EDO  A 296 (-4.4A)
None
None
 1.46A 2vxaD-2r9lA:
undetectable
2vxaE-2r9lA:
undetectable
2vxaL-2r9lA:
undetectable		 2vxaD-2r9lA:
13.19
2vxaE-2r9lA:
13.19
2vxaL-2r9lA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 133
HIS A 178
ARG A 244
ARG A  47
 None
None
EDO  A 296 (-4.4A)
None
 1.47A 2vxaD-2r9lA:
undetectable
2vxaJ-2r9lA:
undetectable
2vxaL-2r9lA:
undetectable		 2vxaD-2r9lA:
13.19
2vxaJ-2r9lA:
13.19
2vxaL-2r9lA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 102
MET A  40
ILE A  44
HIS A 111
 None
None
None
EDO  A 295 (-3.8A)
 1.01A 3eteA-2r9lA:
undetectable
3eteE-2r9lA:
undetectable		 3eteA-2r9lA:
22.18
3eteE-2r9lA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 102
MET A  40
ILE A  44
HIS A 111
 None
None
None
EDO  A 295 (-3.8A)
 1.00A 3eteB-2r9lA:
undetectable
3eteC-2r9lA:
undetectable		 3eteB-2r9lA:
22.18
3eteC-2r9lA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 MET A  40
ILE A  44
HIS A 111
ILE A 102
 None
None
EDO  A 295 (-3.8A)
None
 1.02A 3eteD-2r9lA:
undetectable
3eteF-2r9lA:
undetectable		 3eteD-2r9lA:
22.18
3eteF-2r9lA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  46
PRO A  48
ALA A  49
ALA A 291
PRO A 113
 None
 1.08A 3jb3A-2r9lA:
undetectable		 3jb3A-2r9lA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 259
LEU A 268
THR A 171
ALA A 253
 None
 1.18A 3mbgA-2r9lA:
undetectable
3mbgB-2r9lA:
undetectable		 3mbgA-2r9lA:
22.03
3mbgB-2r9lA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  64
PRO A  91
LEU A  76
ILE A  93
ALA A 107
 None
 1.12A 4a83A-2r9lA:
undetectable		 4a83A-2r9lA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 169
LEU A 177
VAL A 152
LEU A 265
 None
 0.92A 4pwdA-2r9lA:
4.5		 4pwdA-2r9lA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		 2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 107
ARG A 244
SER A 242
ILE A 238
ILE A  44
 None
EDO  A 296 (-4.4A)
None
EDO  A 295 (-4.1A)
None
 1.23A 4qe6A-2r9lA:
0.0		 4qe6A-2r9lA:
21.59