SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r9q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		3 / 3 ALA A 235
VAL A 239
TRP A 243
 None
 0.88A 1c4dA-2r9qA:
undetectable
1c4dB-2r9qA:
undetectable		 1c4dA-2r9qA:
5.38
1c4dB-2r9qA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		3 / 3 TRP A 243
ALA A 235
VAL A 239
 None
 0.94A 1c4dA-2r9qA:
undetectable
1c4dB-2r9qA:
undetectable		 1c4dA-2r9qA:
5.38
1c4dB-2r9qA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		3 / 3 ALA A 235
VAL A 239
TRP A 243
 None
 0.79A 1c4dC-2r9qA:
undetectable
1c4dD-2r9qA:
undetectable		 1c4dC-2r9qA:
5.38
1c4dD-2r9qA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		3 / 3 TRP A 243
ALA A 235
VAL A 239
 None
 0.78A 1c4dC-2r9qA:
undetectable
1c4dD-2r9qA:
undetectable		 1c4dC-2r9qA:
5.38
1c4dD-2r9qA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		3 / 3 GLU A 317
TYR A 294
PHE A 261
 None
 0.95A 1eqbB-2r9qA:
undetectable		 1eqbB-2r9qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		3 / 3 GLU A 317
TYR A 294
PHE A 261
 None
 0.94A 1eqbA-2r9qA:
undetectable		 1eqbA-2r9qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		3 / 3 GLU A 317
TYR A 294
PHE A 261
 None
 0.95A 1eqbD-2r9qA:
undetectable		 1eqbD-2r9qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		3 / 3 GLU A 317
TYR A 294
PHE A 261
 None
 0.95A 1eqbC-2r9qA:
undetectable		 1eqbC-2r9qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		4 / 7 GLY A 301
PRO A 300
ASP A  16
ALA A  15
 None
 1.00A 1gxsA-2r9qA:
undetectable
1gxsB-2r9qA:
undetectable		 1gxsA-2r9qA:
21.03
1gxsB-2r9qA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_C_BEZC602_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		5 / 9 GLY A 301
PRO A 300
ASP A  16
MET A 341
ALA A  15
 None
 1.17A 1gxsC-2r9qA:
undetectable
1gxsD-2r9qA:
0.0		 1gxsC-2r9qA:
21.03
1gxsD-2r9qA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		5 / 9 LEU A  87
VAL A 229
GLY A 118
VAL A 158
ILE A 156
 None
 1.00A 1ohrB-2r9qA:
undetectable		 1ohrB-2r9qA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		5 / 11 LEU A  87
VAL A 229
GLY A 118
VAL A 158
ILE A 156
 None
 0.91A 1t3rB-2r9qA:
undetectable		 1t3rB-2r9qA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		4 / 8 ARG A  47
SER A  30
ARG A 160
ALA A  32
 None
 1.32A 2rk8A-2r9qA:
undetectable		 2rk8A-2r9qA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		5 / 10 LEU A  97
LEU A 147
LEU A 164
LEU A  48
ARG A 163
 None
 1.08A 2xn7A-2r9qA:
undetectable
2xn7B-2r9qA:
undetectable		 2xn7A-2r9qA:
21.86
2xn7B-2r9qA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		5 / 12 PHE A 212
PHE A 302
PHE A 298
LEU A 336
GLU A 268
 None
 1.34A 3apxA-2r9qA:
undetectable		 3apxA-2r9qA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		5 / 12 PHE A 290
LEU A 256
ILE A 207
LEU A 264
LEU A 254
 None
 1.01A 3k2hA-2r9qA:
undetectable		 3k2hA-2r9qA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		5 / 9 ARG A 319
LEU A 254
ARG A 119
GLU A 317
GLY A 219
 None
 1.16A 3nxuB-2r9qA:
undetectable		 3nxuB-2r9qA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		4 / 5 ALA A  42
HIS A 340
MET A 341
ARG A 170
 None
 1.31A 4acaB-2r9qA:
undetectable
4acaC-2r9qA:
undetectable		 4acaB-2r9qA:
21.89
4acaC-2r9qA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		5 / 11 LEU A  87
VAL A 229
GLY A 118
VAL A 158
ILE A 156
 None
 0.95A 4dqhA-2r9qA:
undetectable		 4dqhA-2r9qA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		5 / 10 ALA A  85
PRO A 151
ILE A 122
LEU A 164
ILE A 149
 None
 1.09A 4dtaA-2r9qA:
undetectable		 4dtaA-2r9qA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		4 / 5 ILE A 149
PHE A 242
SER A 165
ASP A 121
 None
 1.21A 4rzvB-2r9qA:
0.2		 4rzvB-2r9qA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		4 / 7 ALA A  21
ARG A 170
GLY A  12
GLU A 339
 None
 0.88A 5bs8A-2r9qA:
undetectable
5bs8C-2r9qA:
undetectable
5bs8D-2r9qA:
undetectable		 5bs8A-2r9qA:
21.48
5bs8C-2r9qA:
21.48
5bs8D-2r9qA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		4 / 6 ALA A  21
ARG A 170
GLY A  12
GLU A 339
 None
 0.94A 5btgA-2r9qA:
undetectable
5btgB-2r9qA:
undetectable
5btgC-2r9qA:
undetectable		 5btgA-2r9qA:
21.48
5btgB-2r9qA:
23.02
5btgC-2r9qA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		4 / 6 ALA A 109
GLN A 166
SER A 165
ASP A 135
 None
 1.17A 5c6pA-2r9qA:
undetectable		 5c6pA-2r9qA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		4 / 4 LEU A  44
ARG A 168
ILE A 167
PHE A 169
 None
 1.29A 5kirB-2r9qA:
undetectable		 5kirB-2r9qA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		4 / 6 ARG A  47
GLY A  49
GLU A  99
SER A  30
 None
 0.98A 5ny7A-2r9qA:
undetectable		 5ny7A-2r9qA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		5 / 9 VAL A  67
ILE A 137
LEU A  46
PRO A  61
ALA A 131
 None
 1.29A 5og9A-2r9qA:
undetectable		 5og9A-2r9qA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_2
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		4 / 4 ASP A 121
PRO A 155
GLU A  88
TYR A  93
 None
 1.37A 5xprA-2r9qA:
0.0		 5xprA-2r9qA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE
(Agrobacterium
fabrum) 		4 / 7 ASP A 232
GLY A  49
SER A 162
GLY A 161
 None
 0.95A 6ekzA-2r9qA:
undetectable		 6ekzA-2r9qA:
13.95