SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r9v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		6 / 12 GLY A 113
ILE A  96
ALA A 242
GLY A 243
ALA A 245
ILE A 130
 None
 1.36A 1bx4A-2r9vA:
2.1		 1bx4A-2r9vA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 11 ASP A  82
VAL A  60
GLY A  37
ILE A  38
VAL A  53
 None
 0.99A 1hxwB-2r9vA:
undetectable		 1hxwB-2r9vA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 8 HIS A 267
TYR A 271
LEU A 264
GLU A 131
 None
 1.11A 1i7zA-2r9vA:
undetectable		 1i7zA-2r9vA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 12 ILE A  38
ILE A  75
ALA A 270
TYR A 237
ARG A  40
 None
 1.47A 1ki7B-2r9vA:
undetectable		 1ki7B-2r9vA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 12 ILE A 169
GLY A 170
ILE A 319
THR A 322
ALA A 357
 None
 1.03A 1nv8B-2r9vA:
3.8		 1nv8B-2r9vA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 12 ILE A 130
ILE A 338
LEU A 264
VAL A 335
ILE A 199
 None
 0.96A 1oipA-2r9vA:
2.0		 1oipA-2r9vA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 11 ILE A 184
THR A 183
LEU A 258
VAL A 224
GLN A 201
 None
 1.15A 1tw4A-2r9vA:
undetectable		 1tw4A-2r9vA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		3 / 3 GLU A 321
THR A 322
LEU A 167
 None
 0.71A 1v8bC-2r9vA:
undetectable		 1v8bC-2r9vA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		3 / 3 GLN A 342
ILE A 343
TYR A 344
 None
 0.63A 1vifA-2r9vA:
undetectable		 1vifA-2r9vA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_2
(MINERALOCORTICOID
RECEPTOR)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 4 LEU A 349
LEU A 362
MET A 418
MET A 157
 None
 1.41A 2oaxB-2r9vA:
0.0		 2oaxB-2r9vA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 11 ASP A  82
VAL A  60
GLY A  37
ILE A  38
VAL A  53
 None
 1.05A 2qhcA-2r9vA:
undetectable		 2qhcA-2r9vA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 8 SER A 363
THR A 339
PRO A 318
LEU A 264
 None
 1.11A 2v0zO-2r9vA:
undetectable		 2v0zO-2r9vA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 8 ILE A  75
ALA A 233
ILE A  38
PHE A  65
 None
 0.77A 2w9sE-2r9vA:
undetectable		 2w9sE-2r9vA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 6 THR A 149
GLN A 187
LEU A 317
LEU A 258
 None
 1.14A 3bgdA-2r9vA:
2.4		 3bgdA-2r9vA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 4 GLU A 346
GLY A 170
THR A 322
GLU A 321
 None
 1.10A 3e9xA-2r9vA:
undetectable		 3e9xA-2r9vA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 11 VAL A 320
ILE A 169
TYR A 344
GLN A 342
THR A 339
 None
 1.10A 3elzB-2r9vA:
undetectable		 3elzB-2r9vA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 12 VAL A 320
ILE A 169
TYR A 344
GLN A 342
THR A 339
 None
 1.10A 3elzC-2r9vA:
undetectable		 3elzC-2r9vA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 11 GLN A 190
PRO A 430
ILE A 158
ILE A 179
PRO A 356
 None
None
None
None
ATP  A 506 ( 4.2A)
 1.47A 3ganA-2r9vA:
undetectable		 3ganA-2r9vA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 12 ILE A 130
LEU A  77
LEU A 235
GLN A 236
VAL A  98
 None
 1.11A 3ix9A-2r9vA:
undetectable		 3ix9A-2r9vA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 6 ARG A 255
VAL A 100
PHE A 250
GLU A 248
 None
 1.47A 3ufrA-2r9vA:
undetectable
3ufrB-2r9vA:
undetectable		 3ufrA-2r9vA:
20.48
3ufrB-2r9vA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 7 MET A 465
ILE A 494
VAL A 435
MET A 429
 None
 1.35A 4f4dA-2r9vA:
undetectable		 4f4dA-2r9vA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 8 ILE A 168
LEU A 317
ILE A 151
GLY A 161
 None
 0.82A 4hb8A-2r9vA:
undetectable		 4hb8A-2r9vA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 5 LYS A 491
LEU A 490
GLU A 487
LEU A 482
 None
 1.38A 4k4yA-2r9vA:
undetectable		 4k4yA-2r9vA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 4 LYS A 491
LEU A 490
GLU A 487
LEU A 482
 None
 1.39A 4k4yE-2r9vA:
undetectable		 4k4yE-2r9vA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 5 LYS A 491
LEU A 490
GLU A 487
LEU A 482
 None
 1.37A 4k4yI-2r9vA:
undetectable		 4k4yI-2r9vA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 5 TYR A 390
THR A 174
LEU A 345
MET A 157
 None
ATP  A 506 ( 4.4A)
None
None
 1.25A 4mbsB-2r9vA:
undetectable		 4mbsB-2r9vA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 8 PHE A 292
THR A 339
SER A 337
TYR A 261
 None
 1.19A 4qb9D-2r9vA:
undetectable		 4qb9D-2r9vA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		3 / 3 GLU A 488
TYR A 445
GLU A 495
 None
 0.69A 4ryaA-2r9vA:
undetectable		 4ryaA-2r9vA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 7 PRO A 332
VAL A 335
ASN A 334
ILE A 338
ILE A 169
 None
 1.47A 5bmvC-2r9vA:
undetectable		 5bmvC-2r9vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 6 ILE A 160
ALA A 302
THR A 315
VAL A 367
 None
 0.89A 5eclD-2r9vA:
undetectable		 5eclD-2r9vA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		6 / 12 GLY A 113
ILE A  96
ALA A 242
GLY A 243
ALA A 245
ILE A 130
 None
 1.16A 5kb6A-2r9vA:
2.1		 5kb6A-2r9vA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		6 / 12 GLY A 113
ILE A  96
ALA A 242
GLY A 243
ALA A 245
ILE A 130
 None
 1.16A 5kb6B-2r9vA:
undetectable		 5kb6B-2r9vA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 9 ASP A  82
VAL A  60
GLY A  37
ILE A  38
VAL A  53
 None
 1.02A 5kr0B-2r9vA:
undetectable		 5kr0B-2r9vA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 10 GLY A 441
GLY A 444
PHE A 461
ILE A 494
PHE A 457
 None
 1.39A 5lbtA-2r9vA:
undetectable
5lbtB-2r9vA:
undetectable		 5lbtA-2r9vA:
19.59
5lbtB-2r9vA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 7 ILE A  38
LEU A  77
THR A  58
ARG A  91
 None
 0.98A 5vc0A-2r9vA:
undetectable		 5vc0A-2r9vA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 12 PHE A 461
LEU A 482
VAL A 379
MET A 382
VAL A 442
 None
 1.15A 5x24A-2r9vA:
undetectable		 5x24A-2r9vA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		5 / 12 GLY A 289
ASN A  66
PHE A  65
TYR A 237
TYR A 330
 None
 1.46A 5yf0A-2r9vA:
3.2		 5yf0A-2r9vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2r9v ATP SYNTHASE SUBUNIT
ALPHA
(Thermotoga
maritima) 		4 / 8 GLN A 164
PRO A 159
ILE A 158
GLU A 166
 None
 0.94A 6hzpA-2r9vA:
undetectable		 6hzpA-2r9vA:
22.11