SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r9y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 12 LEU A  66
LEU A  69
VAL A  70
VAL A  86
HIS A 353
 None
 1.29A 1db1A-2r9yA:
undetectable		 1db1A-2r9yA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 11 LEU A 318
LEU A  81
LEU A  66
SER A  68
ALA A  71
 None
 1.07A 1h9zA-2r9yA:
undetectable		 1h9zA-2r9yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 11 LEU A 318
LEU A  81
LEU A  66
SER A  68
ALA A  71
 None
 1.05A 1ha2A-2r9yA:
undetectable		 1ha2A-2r9yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 12 LEU A 338
ALA A  97
LEU A 117
PRO A 118
LEU A 158
 None
 1.25A 1og5A-2r9yA:
undetectable		 1og5A-2r9yA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 12 PHE A 210
LEU A 401
VAL A 399
PHE A 124
THR A 132
 None
 1.22A 1q23B-2r9yA:
undetectable		 1q23B-2r9yA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 11 PHE A 391
PHE A 218
LEU A 309
VAL A 384
PHE A 388
 None
 1.19A 1q23G-2r9yA:
undetectable		 1q23G-2r9yA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 11 MET A 275
ALA A 261
LEU A 309
VAL A 384
LEU A 312
 None
 1.13A 3fl9C-2r9yA:
undetectable		 3fl9C-2r9yA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 9 MET A 275
ALA A 261
VAL A 384
LEU A 312
PHE A 388
 None
 1.28A 3fl9D-2r9yA:
undetectable		 3fl9D-2r9yA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		6 / 12 MET A 275
ALA A 261
LEU A 309
VAL A 384
LEU A 312
PHE A 388
 None
 1.28A 3fl9G-2r9yA:
undetectable		 3fl9G-2r9yA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 9 MET A 275
ALA A 261
LEU A 309
VAL A 384
LEU A 312
 None
 1.19A 3fl9H-2r9yA:
undetectable		 3fl9H-2r9yA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 10 MET A 275
ALA A 261
LEU A 309
VAL A 384
LEU A 312
 None
 1.21A 3jw5B-2r9yA:
undetectable		 3jw5B-2r9yA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 7 ILE A 139
LEU A 202
LEU A 332
HIS A  92
VAL A 108
 None
 1.28A 3r9vA-2r9yA:
undetectable
3r9vB-2r9yA:
undetectable		 3r9vA-2r9yA:
21.51
3r9vB-2r9yA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 11 ALA A  89
HIS A 353
VAL A 351
LEU A 320
LEU A 204
 None
 0.98A 3sm2B-2r9yA:
undetectable		 3sm2B-2r9yA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		3 / 3 PRO A 276
THR A 277
LEU A 252
 None
 0.63A 3ttrA-2r9yA:
undetectable		 3ttrA-2r9yA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		4 / 8 TRP A 281
PRO A 276
VAL A 260
LEU A 295
 None
 0.94A 3u5kC-2r9yA:
undetectable		 3u5kC-2r9yA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		4 / 6 PHE A 382
ALA A 261
PRO A 276
VAL A 274
 None
 0.96A 4dubB-2r9yA:
undetectable		 4dubB-2r9yA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		5 / 12 ILE A 133
PHE A 159
GLN A 126
LEU A 128
LEU A  84
 None
 1.02A 4g1bD-2r9yA:
undetectable		 4g1bD-2r9yA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		4 / 7 ASN A 206
LEU A  93
LEU A 121
ILE A 139
 None
 0.94A 4okwA-2r9yA:
undetectable		 4okwA-2r9yA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		4 / 6 LEU A 309
PHE A 263
ILE A 392
PHE A 271
 None
 1.13A 4y4dA-2r9yA:
undetectable		 4y4dA-2r9yA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2r9y ALPHA-2-ANTIPLASMIN
(Mus
musculus) 		4 / 6 VAL A 108
HIS A 110
LEU A 109
LEU A  66
 None
 1.23A 5hrqB-2r9yA:
undetectable
5hrqI-2r9yA:
undetectable
5hrqJ-2r9yA:
undetectable		 5hrqB-2r9yA:
5.51
5hrqI-2r9yA:
10.83
5hrqJ-2r9yA:
5.51