SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 8 ILE A 107
LEU A 105
ALA A  23
VAL A  30
 None
 0.71A 1a29A-2r9zA:
undetectable		 1a29A-2r9zA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 10 LEU A 105
ILE A  33
GLY A  11
GLY A  12
ILE A 107
 None
FAD  A 500 ( 4.7A)
FAD  A 500 (-3.1A)
FAD  A 500 ( 4.9A)
None
 0.79A 1sdtA-2r9zA:
undetectable		 1sdtA-2r9zA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		6 / 10 LEU A 105
ALA A  20
ILE A  33
GLY A  11
GLY A  12
ILE A 107
 None
None
FAD  A 500 ( 4.7A)
FAD  A 500 (-3.1A)
FAD  A 500 ( 4.9A)
None
 1.04A 1sdvA-2r9zA:
undetectable		 1sdvA-2r9zA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 8 ILE A 134
ILE A 303
ILE A 122
VAL A  19
 None
 0.69A 2nniA-2r9zA:
undetectable		 2nniA-2r9zA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		3 / 3 ASN A 265
LEU A 269
HIS A 113
 FAD  A 500 ( 4.7A)
FAD  A 500 (-4.6A)
FAD  A 500 (-3.4A)
 0.73A 2q6fB-2r9zA:
undetectable		 2q6fB-2r9zA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 4 TYR A 298
LEU A 300
LEU A 320
HIS A 133
 None
 1.45A 2x7hB-2r9zA:
2.8		 2x7hB-2r9zA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		3 / 3 MET A 283
VAL A 294
GLU A 272
 None
 0.63A 2x9gA-2r9zA:
6.3		 2x9gA-2r9zA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 6 MET A 413
SER A 440
PRO A 347
GLY A 407
 None
 1.41A 2y7pA-2r9zA:
undetectable		 2y7pA-2r9zA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 7 THR A 138
GLY A 140
PRO A 264
ASN A 265
GLY A 305
 FAD  A 500 (-3.9A)
None
None
FAD  A 500 ( 4.7A)
None
 1.11A 3tajA-2r9zA:
undetectable		 3tajA-2r9zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 6 GLY A  11
ARG A 115
ILE A  33
LEU A  38
 FAD  A 500 (-3.1A)
CL  A 465 ( 3.7A)
FAD  A 500 ( 4.7A)
None
 1.25A 4ac9C-2r9zA:
undetectable		 4ac9C-2r9zA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 6 THR A 138
GLY A 140
PRO A 264
ASN A 265
GLY A 305
 FAD  A 500 (-3.9A)
None
None
FAD  A 500 ( 4.7A)
None
 1.11A 4fjpA-2r9zA:
undetectable		 4fjpA-2r9zA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 7 GLY A 140
PRO A 264
ASN A 265
GLY A 305
 None
None
FAD  A 500 ( 4.7A)
None
 0.83A 4forA-2r9zA:
undetectable		 4forA-2r9zA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 11 GLY A 402
GLY A 352
LEU A 353
GLU A 357
HIS A 404
 None
 1.12A 4l8fB-2r9zA:
undetectable		 4l8fB-2r9zA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 11 GLY A 402
GLY A 352
LEU A 353
GLU A 357
HIS A 404
 None
 1.13A 4l8fD-2r9zA:
undetectable		 4l8fD-2r9zA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 7 VAL A  52
MET A  53
ALA A  56
PHE A 188
 None
 0.86A 4lb2A-2r9zA:
undetectable		 4lb2A-2r9zA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 7 VAL A  52
ILE A  91
ILE A  94
ALA A  93
 None
 0.87A 4lv9A-2r9zA:
undetectable		 4lv9A-2r9zA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 5 ASN A  44
ALA A  37
GLY A  39
ASP A  99
 None
 0.86A 4n48A-2r9zA:
1.9		 4n48A-2r9zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 5 ILE A 257
LEU A 181
ASP A 157
VAL A  84
 None
 0.92A 4nkxB-2r9zA:
undetectable		 4nkxB-2r9zA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 11 LEU A 105
ALA A  20
ILE A  33
GLY A  12
ILE A 107
 None
None
FAD  A 500 ( 4.7A)
FAD  A 500 ( 4.9A)
None
 0.95A 4qgiB-2r9zA:
undetectable		 4qgiB-2r9zA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 5 ILE A 134
PHE A  26
SER A 130
HIS A 120
 None
None
None
NI  A 466 (-3.4A)
 1.37A 4rzvB-2r9zA:
undetectable		 4rzvB-2r9zA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 8 ALA A 137
VAL A 135
GLY A  15
ALA A 313
GLY A 317
 FAD  A 500 (-4.1A)
None
FAD  A 500 (-3.5A)
FAD  A 500 ( 3.7A)
None
 1.23A 4zjzB-2r9zA:
undetectable		 4zjzB-2r9zA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 6 SER A  35
GLY A 301
ASP A 302
GLY A  15
 FAD  A 500 (-3.4A)
FAD  A 500 (-3.2A)
FAD  A 500 (-2.7A)
FAD  A 500 (-3.5A)
 0.78A 5cdpA-2r9zA:
undetectable
5cdpB-2r9zA:
undetectable		 5cdpA-2r9zA:
22.69
5cdpB-2r9zA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		4 / 4 VAL A 421
GLY A 424
ARG A 399
VAL A 401
 None
 1.49A 5d4nA-2r9zA:
undetectable
5d4nB-2r9zA:
undetectable		 5d4nA-2r9zA:
13.29
5d4nB-2r9zA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 12 ALA A  24
LEU A   7
ALA A  20
LEU A  32
GLY A 106
 None
 1.49A 5jglA-2r9zA:
2.4		 5jglA-2r9zA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 12 ALA A 137
GLY A 139
ALA A   9
LEU A   7
GLY A  15
 FAD  A 500 (-4.1A)
FAD  A 500 (-3.2A)
None
None
FAD  A 500 (-3.5A)
 1.27A 5jglB-2r9zA:
undetectable		 5jglB-2r9zA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 11 GLY A  11
GLU A  34
ALA A 114
LEU A 269
ASN A 265
 FAD  A 500 (-3.1A)
FAD  A 500 (-2.7A)
FAD  A 500 (-3.8A)
FAD  A 500 (-4.6A)
FAD  A 500 ( 4.7A)
 1.09A 5x6yC-2r9zA:
undetectable		 5x6yC-2r9zA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 12 GLY A  12
GLY A  16
ALA A   9
ASP A 111
LEU A  38
 FAD  A 500 ( 4.9A)
None
None
None
None
 0.94A 6b3aA-2r9zA:
2.9		 6b3aA-2r9zA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 10 GLY A  11
GLY A  13
GLU A  34
THR A 138
ASN A 265
 FAD  A 500 (-3.1A)
FAD  A 500 (-3.1A)
FAD  A 500 (-2.7A)
FAD  A 500 (-3.9A)
FAD  A 500 ( 4.7A)
 0.89A 6exiA-2r9zA:
3.5		 6exiA-2r9zA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		5 / 12 GLY A  11
GLY A  13
GLU A  34
THR A 138
ASN A 265
 FAD  A 500 (-3.1A)
FAD  A 500 (-3.1A)
FAD  A 500 (-2.7A)
FAD  A 500 (-3.9A)
FAD  A 500 ( 4.7A)
 0.92A 6exiC-2r9zA:
3.3
6exiD-2r9zA:
3.5		 6exiC-2r9zA:
9.23
6exiD-2r9zA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		3 / 3 LEU A 362
LEU A 353
ARG A 361
 None
 0.64A 6fgcA-2r9zA:
undetectable		 6fgcA-2r9zA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2r9z GLUTATHIONE AMIDE
REDUCTASE
(Marichromatium
gracile) 		3 / 3 LEU A 362
LEU A 353
ARG A 361
 None
 0.65A 6fgdA-2r9zA:
4.9		 6fgdA-2r9zA:
22.11