SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ra1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ra1 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A 139
ILE A 202
HIS A 158
 None
 0.75A 1k74A-2ra1A:
undetectable		 1k74A-2ra1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 2ra1 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 211
ALA A 223
LEU A 220
ALA A 259
GLU A 257
 None
 1.11A 2bxeA-2ra1A:
3.4		 2bxeA-2ra1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2ra1 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 256
LEU A 220
ASP A 221
LYS A 224
 None
 1.09A 3lsfH-2ra1A:
undetectable		 3lsfH-2ra1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 2ra1 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 256
LEU A 220
ASP A 221
LYS A 224
 None
 0.96A 3lslA-2ra1A:
undetectable
3lslD-2ra1A:
undetectable		 3lslA-2ra1A:
21.14
3lslD-2ra1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 2ra1 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 256
LEU A 220
ASP A 221
LYS A 224
 None
 0.98A 3lslA-2ra1A:
undetectable
3lslD-2ra1A:
undetectable		 3lslA-2ra1A:
21.14
3lslD-2ra1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 2ra1 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 256
LEU A 220
ASP A 221
LYS A 224
 None
 0.97A 3lslG-2ra1A:
undetectable		 3lslG-2ra1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ra1 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 SER A 350
PHE A 275
VAL A 334
PHE A 279
ALA A 318
 None
 1.33A 3u9fD-2ra1A:
undetectable
3u9fE-2ra1A:
undetectable		 3u9fD-2ra1A:
20.19
3u9fE-2ra1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ra1 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 SER A 350
PHE A 275
VAL A 334
PHE A 279
ALA A 318
 None
 1.31A 3u9fG-2ra1A:
undetectable
3u9fH-2ra1A:
undetectable		 3u9fG-2ra1A:
20.19
3u9fH-2ra1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 2ra1 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 120
GLY A 117
GLU A 118
 None
 0.46A 6fgdA-2ra1A:
undetectable		 6fgdA-2ra1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 2ra1 SURFACE LAYER
PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 242
VAL A 237
ASP A 239
 None
 0.58A 6fgdA-2ra1A:
undetectable		 6fgdA-2ra1A:
22.13