SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ra5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 LEU A 152
PRO A 153
LEU A 156
 None
 0.41A 1hrkA-2ra5A:
undetectable		 1hrkA-2ra5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ARG A 138
ARG A  71
ARG A 136
 SRT  A 247 (-3.8A)
None
SRT  A 247 (-2.9A)
 0.88A 1l7fA-2ra5A:
undetectable		 1l7fA-2ra5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 ARG A 138
ARG A  71
ARG A 136
 SRT  A 247 (-3.8A)
None
SRT  A 247 (-2.9A)
 0.89A 1l7hA-2ra5A:
undetectable		 1l7hA-2ra5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 GLY A 226
LEU A 169
ARG A 136
MET A 173
LEU A 180
 None
SRT  A 247 (-4.0A)
SRT  A 247 (-2.9A)
None
None
 0.97A 1p93C-2ra5A:
undetectable		 1p93C-2ra5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 HIS A 228
ALA A 146
TYR A 147
LEU A 200
GLU A 135
 SRT  A 247 ( 4.8A)
None
None
None
None
 1.45A 2azqA-2ra5A:
undetectable		 2azqA-2ra5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 6 ARG A 190
THR A 210
ALA A 206
ALA A 192
 None
 1.17A 3ns1C-2ra5A:
undetectable		 3ns1C-2ra5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 VAL A 113
THR A 111
ARG A 133
 None
 0.64A 5b2sB-2ra5A:
undetectable		 5b2sB-2ra5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 VAL A 113
THR A 111
ARG A 133
 None
 0.68A 5b2tB-2ra5A:
undetectable		 5b2tB-2ra5A:
11.85