SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2raa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		5 / 8 LEU A 142
MET A  26
GLU A  29
ALA A  30
VAL A 152
 None
 1.03A 1a29A-2raaA:
undetectable		 1a29A-2raaA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		5 / 9 LEU A 142
MET A  26
GLU A  29
ALA A  30
VAL A 152
 None
 1.11A 1ctrA-2raaA:
undetectable		 1ctrA-2raaA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		5 / 12 ASN A  57
ILE A  59
ASP A  61
LEU A 145
GLY A  60
 None
 1.12A 1likA-2raaA:
4.6		 1likA-2raaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		4 / 7 GLY A  19
MET A  26
ILE A  79
PRO A 137
 SO4  A 193 (-3.4A)
None
None
None
 1.06A 1rxcC-2raaA:
undetectable		 1rxcC-2raaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		4 / 7 GLY A  19
MET A  26
ILE A  79
PRO A 137
 SO4  A 193 (-3.4A)
None
None
None
 1.07A 1rxcD-2raaA:
undetectable		 1rxcD-2raaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		4 / 7 GLY A  19
MET A  26
ILE A  79
PRO A 137
 SO4  A 193 (-3.4A)
None
None
None
 1.06A 1rxcL-2raaA:
undetectable		 1rxcL-2raaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		5 / 12 GLY A  14
ASP A  80
VAL A  77
ALA A  16
GLY A  17
 None
None
None
SO4  A 193 ( 4.9A)
SO4  A 193 (-3.2A)
 0.87A 3ku1C-2raaA:
undetectable		 3ku1C-2raaA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		4 / 8 ILE A 136
GLY A 135
PRO A 140
ASN A 101
 None
 0.93A 3lslA-2raaA:
undetectable
3lslD-2raaA:
undetectable		 3lslA-2raaA:
21.69
3lslD-2raaA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		4 / 8 PRO A 140
ASN A 101
ILE A 136
GLY A 135
 None
 0.94A 3lslA-2raaA:
undetectable
3lslD-2raaA:
undetectable		 3lslA-2raaA:
21.69
3lslD-2raaA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		4 / 4 VAL A  89
PHE A 115
PHE A 106
VAL A 121
 None
 1.45A 3rv5C-2raaA:
0.0
3rv5D-2raaA:
0.0		 3rv5C-2raaA:
16.75
3rv5D-2raaA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		4 / 8 LEU A 142
LEU A 145
VAL A 146
ILE A 151
 None
 0.94A 4oj4A-2raaA:
undetectable		 4oj4A-2raaA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		5 / 11 LEU A  99
ILE A  79
TRP A  12
LEU A  27
LEU A 142
 None
 1.42A 4yvpA-2raaA:
undetectable		 4yvpA-2raaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		5 / 9 GLY A 184
GLN A  18
ASN A 138
LEU A 142
LEU A 154
 None
 1.41A 5fhzB-2raaA:
undetectable		 5fhzB-2raaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		4 / 7 THR A 139
ASN A  57
VAL A  38
GLU A  43
 None
 1.11A 5tudA-2raaA:
undetectable		 5tudA-2raaA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		4 / 6 HIS A  13
ASN A  57
VAL A  75
LEU A  92
 None
 1.30A 5xdhA-2raaA:
0.6
5xdhC-2raaA:
0.0		 5xdhA-2raaA:
18.52
5xdhC-2raaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		4 / 5 HIS A  13
ASN A  57
VAL A  75
LEU A  92
 None
 1.35A 5xdhB-2raaA:
0.0		 5xdhB-2raaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 2raa PYRUVATE SYNTHASE
SUBUNIT PORC
(Thermotoga
maritima) 		4 / 5 HIS A  13
ASN A  57
VAL A  75
LEU A  92
 None
 1.38A 5xdhD-2raaA:
undetectable		 5xdhD-2raaA:
18.52