SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		4 / 7 LEU A 316
TYR A 320
HIS A 309
THR A 410
 None
 1.33A 1afsA-2radA:
undetectable		 1afsA-2radA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		4 / 7 LEU A 316
TYR A 320
HIS A 309
THR A 410
 None
 1.32A 1afsB-2radA:
undetectable		 1afsB-2radA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 GLY A  81
SER A 342
LEU A 316
MET A 315
LEU A 430
 None
 1.26A 1fm6D-2radA:
0.0		 1fm6D-2radA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		4 / 5 TRP A 116
ILE A 261
ASP A 123
ASN A 157
 None
 1.48A 1kiaD-2radA:
1.3		 1kiaD-2radA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		4 / 7 LEU A 387
ILE A 385
ALA A 390
ILE A  42
 None
 0.91A 1oniB-2radA:
0.8
1oniC-2radA:
undetectable		 1oniB-2radA:
17.74
1oniC-2radA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 11 GLY A  81
GLU A  82
GLY A 305
ILE A 302
LEU A  62
 None
 1.15A 1p91A-2radA:
2.0		 1p91A-2radA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 10 GLY A  81
GLU A 113
THR A 341
ASN A 307
VAL A 310
 None
 1.31A 1pwyE-2radA:
2.3		 1pwyE-2radA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 ILE A 234
ILE A 184
ILE A 255
LEU A 245
ARG A 198
 None
 0.92A 1qhsA-2radA:
5.0		 1qhsA-2radA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 ILE A 234
ILE A 184
ILE A 255
LEU A 245
ARG A 198
 None
 0.93A 1qhyA-2radA:
5.3		 1qhyA-2radA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 THR A 409
GLU A 113
LEU A 316
GLY A 407
PHE A 141
 None
 1.47A 3ce6B-2radA:
undetectable		 3ce6B-2radA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 GLY A 115
GLY A 170
ILE A 173
LEU A 122
VAL A 180
 None
 1.28A 3fzgA-2radA:
1.2		 3fzgA-2radA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		4 / 7 VAL A  98
LYS A  99
TRP A 304
GLU A 145
 None
 1.23A 3hs4A-2radA:
undetectable		 3hs4A-2radA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		4 / 7 VAL A 209
TYR A 227
LYS A 204
GLU A 201
 None
 1.29A 3hs4A-2radA:
undetectable		 3hs4A-2radA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		3 / 3 ASP A 230
ARG A 198
LYS A 202
 None
 1.02A 3wipG-2radA:
undetectable		 3wipG-2radA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 LEU A 430
LEU A 423
GLN A 401
MET A 315
VAL A 419
 None
 1.28A 3zqtA-2radA:
undetectable		 3zqtA-2radA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		4 / 5 HIS A  95
LEU A 122
TRP A 304
ASP A 123
 None
 1.24A 4aqlA-2radA:
undetectable		 4aqlA-2radA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 PHE A 107
ALA A  75
THR A 341
VAL A 431
LEU A  68
 None
 1.29A 4qynA-2radA:
undetectable		 4qynA-2radA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		3 / 3 HIS A 297
GLU A 296
TRP A 293
 None
 1.12A 5odqD-2radA:
undetectable		 5odqD-2radA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		3 / 3 HIS A 297
GLU A 296
TRP A 293
 None
 1.03A 5odrD-2radA:
undetectable		 5odrD-2radA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		3 / 3 HIS A 283
ASP A 284
HIS A 309
 None
 0.77A 5oexA-2radA:
undetectable		 5oexA-2radA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		3 / 3 HIS A 283
ASP A 284
HIS A 309
 None
 0.77A 5oexB-2radA:
undetectable		 5oexB-2radA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		3 / 3 HIS A 283
ASP A 284
HIS A 309
 None
 0.76A 5oexC-2radA:
undetectable		 5oexC-2radA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 VAL A 140
MET A 287
VAL A 310
PHE A 427
GLY A 407
 None
 1.23A 6brdA-2radA:
undetectable		 6brdA-2radA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 GLY A 115
GLN A 174
ILE A 169
HIS A 309
TYR A 320
 None
 1.49A 6md4A-2radA:
undetectable		 6md4A-2radA:
11.60