SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN
(Rhodococcus
jostii) 		3 / 3 TRP A  66
HIS A 111
MET A 115
 None
 0.96A 1l5qB-2raeA:
undetectable		 1l5qB-2raeA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 12 LEU A 163
LEU A 164
LEU A  80
MET A  76
TYR A 142
 None
 1.26A 1sqnA-2raeA:
undetectable		 1sqnA-2raeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN
(Rhodococcus
jostii) 		5 / 12 LEU A 163
LEU A 164
LEU A  80
MET A  76
TYR A 142
 None
 1.24A 2w8yB-2raeA:
undetectable		 2w8yB-2raeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN
(Rhodococcus
jostii) 		3 / 3 GLU A 172
LEU A 175
ASP A 176
 None
 0.44A 3ko0A-2raeA:
undetectable		 3ko0A-2raeA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN
(Rhodococcus
jostii) 		3 / 3 GLU A 172
LEU A 175
ASP A 176
 None
 0.30A 3ko0T-2raeA:
undetectable		 3ko0T-2raeA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN
(Rhodococcus
jostii) 		3 / 3 LEU A  73
HIS A  72
MET A  76
 None
 0.79A 3thrD-2raeA:
undetectable		 3thrD-2raeA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN
(Rhodococcus
jostii) 		4 / 7 MET A 131
ILE A 118
ARG A 114
MET A  76
 None
 1.36A 4f4dA-2raeA:
undetectable		 4f4dA-2raeA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN
(Rhodococcus
jostii) 		4 / 8 LEU A 182
LEU A 186
MET A 190
THR A  94
 None
 1.18A 5hs6A-2raeA:
undetectable		 5hs6A-2raeA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN
(Rhodococcus
jostii) 		3 / 3 ALA A 102
PHE A 100
GLN A  79
 None
 0.82A 6eceA-2raeA:
undetectable		 6eceA-2raeA:
23.96