SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2raf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		5 / 12 THR A 114
VAL A  68
PHE A 141
VAL A 128
THR A 109
 None
 1.34A 1q23B-2rafA:
undetectable		 1q23B-2rafA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		5 / 11 THR A 114
VAL A  68
PHE A 141
VAL A 128
THR A 109
 None
 1.34A 1q23F-2rafA:
undetectable		 1q23F-2rafA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		4 / 8 LEU A 150
ALA A  22
ILE A  21
GLY A  16
 None
 0.84A 1sv9A-2rafA:
undetectable		 1sv9A-2rafA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		5 / 12 ILE A  70
PHE A 141
LEU A 145
LEU A 150
LEU A 115
 NAP  A 200 ( 4.3A)
None
None
None
None
 1.21A 2bxfA-2rafA:
undetectable		 2bxfA-2rafA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		5 / 12 ILE A  15
GLY A   7
GLY A   9
ALA A  14
VAL A  46
 None
NAP  A 200 ( 3.5A)
NAP  A 200 ( 3.2A)
None
NAP  A 200 ( 4.1A)
 1.03A 2yvlA-2rafA:
3.4		 2yvlA-2rafA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		5 / 12 ILE A  15
GLY A   7
GLY A   9
ALA A  14
VAL A  46
 None
NAP  A 200 ( 3.5A)
NAP  A 200 ( 3.2A)
None
NAP  A 200 ( 4.1A)
 1.06A 2yvlB-2rafA:
3.5		 2yvlB-2rafA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 168
PRO A  73
ALA A  90
ALA A  91
LEU A 129
 None
 1.26A 3mteA-2rafA:
2.9		 3mteA-2rafA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		5 / 9 GLN A  95
ALA A  91
LEU A  94
LEU A  62
ALA A  59
 None
 1.04A 3ozvB-2rafA:
2.3		 3ozvB-2rafA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		4 / 8 GLN A  95
ALA A  91
LEU A  94
LEU A  62
 None
 0.87A 3ozwA-2rafA:
undetectable		 3ozwA-2rafA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		5 / 12 LEU A 115
ILE A  70
GLU A  20
GLY A  12
GLY A   9
 None
NAP  A 200 ( 4.3A)
None
None
NAP  A 200 ( 3.2A)
 1.21A 4hfpB-2rafA:
undetectable		 4hfpB-2rafA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		3 / 3 PRO A 149
ASN A  18
HIS A  17
 None
 0.99A 4ma3H-2rafA:
undetectable
4ma3L-2rafA:
undetectable		 4ma3H-2rafA:
17.35
4ma3L-2rafA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		5 / 5 LEU A  98
ALA A  91
THR A  71
VAL A  46
ILE A  70
 None
None
NAP  A 200 ( 4.2A)
NAP  A 200 ( 4.1A)
NAP  A 200 ( 4.3A)
 1.40A 4xe3B-2rafA:
undetectable		 4xe3B-2rafA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		5 / 11 VAL A 130
VAL A 152
VAL A 128
PHE A 107
ILE A   3
 None
 1.07A 5e4dB-2rafA:
undetectable		 5e4dB-2rafA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE
(Lactobacillus
plantarum) 		5 / 12 ALA A 131
PHE A 141
ASN A 108
LEU A 164
LEU A 145
 None
 1.19A 5x24A-2rafA:
undetectable		 5x24A-2rafA:
17.75