SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 HIS A 229
HIS A 250
MET A 181
HIS A 186
ASP A 360
 ZN  A 419 ( 3.5A)
ZN  A 419 ( 3.4A)
None
None
CL  A 420 ( 4.1A)
 1.24A 1a4lA-2ragA:
5.5		 1a4lA-2ragA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		10 / 12 ASP A  55
TYR A  98
GLU A 159
HIS A 186
HIS A 229
HIS A 250
ARG A 261
ASN A 281
TYR A 284
ASP A 360
 ZN  A 418 ( 2.2A)
None
ZN  A 418 ( 2.3A)
None
ZN  A 419 ( 3.5A)
ZN  A 419 ( 3.4A)
CL  A 420 ( 4.6A)
None
CL  A 420 ( 4.8A)
CL  A 420 ( 4.1A)
 0.46A 1ituA-2ragA:
46.7		 1ituA-2ragA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 TYR A  98
GLU A 159
HIS A 186
HIS A  53
ASP A 360
 None
ZN  A 418 ( 2.3A)
None
ZN  A 418 ( 3.4A)
CL  A 420 ( 4.1A)
 1.12A 1ituA-2ragA:
46.7		 1ituA-2ragA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		9 / 12 ASP A  55
TYR A  98
GLU A 159
HIS A 186
HIS A 229
HIS A 250
ARG A 261
TYR A 284
ASP A 360
 ZN  A 418 ( 2.2A)
None
ZN  A 418 ( 2.3A)
None
ZN  A 419 ( 3.5A)
ZN  A 419 ( 3.4A)
CL  A 420 ( 4.6A)
CL  A 420 ( 4.8A)
CL  A 420 ( 4.1A)
 0.46A 1ituB-2ragA:
46.7		 1ituB-2ragA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 TYR A  98
GLU A 159
HIS A 186
HIS A  53
ASP A 360
 None
ZN  A 418 ( 2.3A)
None
ZN  A 418 ( 3.4A)
CL  A 420 ( 4.1A)
 1.10A 1ituB-2ragA:
46.7		 1ituB-2ragA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 7 LEU A 376
PHE A 336
MET A 340
SER A 342
 None
 0.94A 1wrlE-2ragA:
undetectable
1wrlF-2ragA:
undetectable		 1wrlE-2ragA:
11.82
1wrlF-2ragA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		3 / 3 SER A 282
GLU A 371
ASP A 326
 None
 0.83A 2avdB-2ragA:
undetectable		 2avdB-2ragA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 GLY A 358
VAL A  80
GLY A  92
GLY A  93
PRO A  57
 None
 0.70A 2avvD-2ragA:
undetectable		 2avvD-2ragA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		6 / 12 LEU A 268
ALA A 248
ASP A 226
ILE A 404
ALA A 350
ILE A 278
 None
 1.47A 2nmzA-2ragA:
undetectable		 2nmzA-2ragA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 5 GLY A  64
HIS A  75
ASP A 372
ASP A  69
 None
 1.10A 2oxtB-2ragA:
undetectable		 2oxtB-2ragA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 6 ARG A  62
PHE A  60
ILE A  67
PHE A  95
 None
 1.18A 2qeiA-2ragA:
0.6		 2qeiA-2ragA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 THR A  52
GLY A 358
ASN A 281
ASP A  51
GLY A  92
 None
 1.13A 3eeyJ-2ragA:
undetectable		 3eeyJ-2ragA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 VAL A 171
LEU A 168
ILE A 225
GLY A 183
SER A 161
 None
 1.13A 3kk6B-2ragA:
undetectable		 3kk6B-2ragA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 8 ALA A 112
ALA A 116
THR A 120
LEU A 179
 None
 1.00A 3l4dD-2ragA:
undetectable		 3l4dD-2ragA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		3 / 3 TYR A 339
MET A  85
LEU A  54
 None
 0.71A 3vw1D-2ragA:
0.7		 3vw1D-2ragA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 7 THR A  56
TRP A  65
HIS A  71
PHE A  95
 None
 1.28A 4awuA-2ragA:
7.4		 4awuA-2ragA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.91A 4qvlK-2ragA:
undetectable
4qvlL-2ragA:
undetectable		 4qvlK-2ragA:
20.38
4qvlL-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
THR A 380
GLY A  89
GLY A  88
ASP A 375
 None
 1.03A 4qvlK-2ragA:
undetectable
4qvlL-2ragA:
undetectable		 4qvlK-2ragA:
20.38
4qvlL-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.90A 4qvlY-2ragA:
undetectable
4qvlZ-2ragA:
undetectable		 4qvlY-2ragA:
20.38
4qvlZ-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
THR A 380
GLY A  89
GLY A  88
ASP A 375
 None
 1.03A 4qvlY-2ragA:
undetectable
4qvlZ-2ragA:
undetectable		 4qvlY-2ragA:
20.38
4qvlZ-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 9 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.91A 4qvmK-2ragA:
undetectable
4qvmL-2ragA:
undetectable		 4qvmK-2ragA:
20.38
4qvmL-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 9 THR A  49
THR A 380
GLY A  89
GLY A  88
ASP A 375
 None
 1.02A 4qvmK-2ragA:
undetectable
4qvmL-2ragA:
undetectable		 4qvmK-2ragA:
20.38
4qvmL-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 10 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.92A 4qvmY-2ragA:
undetectable
4qvmZ-2ragA:
undetectable		 4qvmY-2ragA:
20.38
4qvmZ-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 10 THR A  49
THR A 380
GLY A  89
GLY A  88
ASP A 375
 None
 1.02A 4qvmY-2ragA:
undetectable
4qvmZ-2ragA:
undetectable		 4qvmY-2ragA:
20.38
4qvmZ-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 10 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.95A 4qvpK-2ragA:
undetectable
4qvpL-2ragA:
undetectable		 4qvpK-2ragA:
20.38
4qvpL-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 10 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.94A 4qvpY-2ragA:
undetectable
4qvpZ-2ragA:
undetectable		 4qvpY-2ragA:
20.38
4qvpZ-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 8 THR A  49
GLY A  89
GLY A  88
ASP A 372
 None
 0.83A 4qvvK-2ragA:
undetectable
4qvvL-2ragA:
undetectable		 4qvvK-2ragA:
20.38
4qvvL-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 8 THR A  49
THR A 380
GLY A  89
GLY A  88
 None
 0.79A 4qvvK-2ragA:
undetectable
4qvvL-2ragA:
undetectable		 4qvvK-2ragA:
20.38
4qvvL-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 8 THR A  49
GLY A  89
GLY A  88
ASP A 372
 None
 0.82A 4qvvY-2ragA:
undetectable
4qvvZ-2ragA:
undetectable		 4qvvY-2ragA:
20.38
4qvvZ-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 8 THR A  49
THR A 380
GLY A  89
GLY A  88
 None
 0.79A 4qvvY-2ragA:
undetectable
4qvvZ-2ragA:
undetectable		 4qvvY-2ragA:
20.38
4qvvZ-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.90A 4qvwK-2ragA:
undetectable
4qvwL-2ragA:
undetectable		 4qvwK-2ragA:
20.38
4qvwL-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
THR A 380
GLY A  89
GLY A  88
ASP A 375
 None
 1.03A 4qvwK-2ragA:
undetectable
4qvwL-2ragA:
undetectable		 4qvwK-2ragA:
20.38
4qvwL-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.90A 4qvwY-2ragA:
undetectable
4qvwZ-2ragA:
undetectable		 4qvwY-2ragA:
20.38
4qvwZ-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
THR A 380
GLY A  89
GLY A  88
ASP A 375
 None
 1.03A 4qvwY-2ragA:
undetectable
4qvwZ-2ragA:
undetectable		 4qvwY-2ragA:
20.38
4qvwZ-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.95A 4qw1K-2ragA:
undetectable
4qw1L-2ragA:
undetectable		 4qw1K-2ragA:
20.43
4qw1L-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 10 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.95A 4qw1Y-2ragA:
undetectable
4qw1Z-2ragA:
undetectable		 4qw1Y-2ragA:
20.43
4qw1Z-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 10 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.90A 4qw3K-2ragA:
undetectable
4qw3L-2ragA:
undetectable		 4qw3K-2ragA:
20.38
4qw3L-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 10 THR A  49
THR A 380
GLY A  89
GLY A  88
ASP A 375
 None
 1.02A 4qw3K-2ragA:
undetectable
4qw3L-2ragA:
undetectable		 4qw3K-2ragA:
20.38
4qw3L-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 10 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.90A 4qw3Y-2ragA:
undetectable
4qw3Z-2ragA:
undetectable		 4qw3Y-2ragA:
20.38
4qw3Z-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 10 THR A  49
THR A 380
GLY A  89
GLY A  88
ASP A 375
 None
 1.02A 4qw3Y-2ragA:
undetectable
4qw3Z-2ragA:
undetectable		 4qw3Y-2ragA:
20.38
4qw3Z-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 5 ILE A 278
HIS A 186
TYR A 207
VAL A 234
 None
 1.23A 4s0vA-2ragA:
undetectable		 4s0vA-2ragA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 4 SER A 249
ASP A  51
ASP A  81
ASP A  55
 None
None
None
ZN  A 418 ( 2.2A)
 1.32A 4uciA-2ragA:
0.0		 4uciA-2ragA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 4 SER A 249
ASP A  51
ASP A  81
ASP A  55
 None
None
None
ZN  A 418 ( 2.2A)
 1.35A 4uciB-2ragA:
0.0		 4uciB-2ragA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		3 / 3 SER A 161
ASP A 236
ASP A 226
 None
 0.79A 4uckA-2ragA:
undetectable		 4uckA-2ragA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 6 LEU A  82
PHE A  95
THR A  56
VAL A  80
 None
 1.10A 4udaA-2ragA:
undetectable		 4udaA-2ragA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 SER A 228
VAL A 401
ASP A 226
ILE A 247
LEU A 263
 None
 1.10A 4y8wA-2ragA:
undetectable		 4y8wA-2ragA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 SER A 228
VAL A 401
ASP A 226
ILE A 247
LEU A 263
 None
 1.11A 4y8wB-2ragA:
undetectable		 4y8wB-2ragA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.90A 5bxnK-2ragA:
undetectable
5bxnL-2ragA:
undetectable		 5bxnK-2ragA:
20.38
5bxnL-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
THR A 380
GLY A  89
GLY A  88
ASP A 375
 None
 1.03A 5bxnK-2ragA:
undetectable
5bxnL-2ragA:
undetectable		 5bxnK-2ragA:
20.38
5bxnL-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
ALA A 359
GLY A  89
GLY A  88
ASP A 372
 None
 0.89A 5bxnY-2ragA:
undetectable
5bxnZ-2ragA:
undetectable		 5bxnY-2ragA:
20.38
5bxnZ-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 THR A  49
THR A 380
GLY A  89
GLY A  88
ASP A 375
 None
 1.02A 5bxnY-2ragA:
undetectable
5bxnZ-2ragA:
undetectable		 5bxnY-2ragA:
20.38
5bxnZ-2ragA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 6 ARG A 333
ASP A 375
GLY A 369
ASP A 368
 None
 1.12A 5hp1A-2ragA:
undetectable		 5hp1A-2ragA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 LEU A 268
ALA A 248
ASP A 226
GLY A 358
ILE A 278
 None
 1.00A 5t2zA-2ragA:
undetectable		 5t2zA-2ragA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 ASN A  86
LEU A  90
GLY A  89
GLY A  88
LEU A  48
 None
 0.85A 5uc1B-2ragA:
undetectable		 5uc1B-2ragA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 7 VAL A  73
LEU A  50
PHE A 370
LEU A 376
 None
 1.20A 6aycA-2ragA:
undetectable		 6aycA-2ragA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		4 / 5 TYR A 207
GLN A 237
GLY A 276
ILE A 225
 None
 1.35A 6debB-2ragA:
undetectable		 6debB-2ragA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 LEU A  82
ASP A  51
GLY A  92
ASP A  91
ILE A 379
 None
 1.08A 6dwnA-2ragA:
undetectable		 6dwnA-2ragA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 10 ALA A 193
LEU A 192
VAL A 164
ILE A  99
ALA A 182
 None
 1.08A 6h1lA-2ragA:
undetectable		 6h1lA-2ragA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 11 ALA A 193
LEU A 192
VAL A 164
ILE A  99
ALA A 182
 None
 1.06A 6h1lB-2ragA:
undetectable		 6h1lB-2ragA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 VAL A 401
VAL A 405
ASP A 360
PHE A 155
VAL A  96
 None
None
CL  A 420 ( 4.1A)
None
None
 1.42A 6iblA-2ragA:
undetectable		 6iblA-2ragA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 12 VAL A 401
VAL A 405
ASP A 360
PHE A 155
VAL A  96
 None
None
CL  A 420 ( 4.1A)
None
None
 1.38A 6iblB-2ragA:
undetectable		 6iblB-2ragA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2rag DIPEPTIDASE
(Caulobacter
vibrioides) 		5 / 9 ILE A 396
ALA A 395
GLY A 399
LEU A 402
GLY A 275
 None
 1.11A 6nm4B-2ragA:
undetectable		 6nm4B-2ragA:
19.74