SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ral'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		3 / 3 SER A 535
GLU A 510
ASP A 493
 None
 0.86A 2zthA-2ralA:
undetectable		 2zthA-2ralA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		3 / 3 SER A 535
GLU A 510
ASP A 493
 None
 0.83A 3bwyA-2ralA:
undetectable		 3bwyA-2ralA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		4 / 4 ASP A 378
ASP A 375
GLY A 324
THR A 359
 None
 1.30A 3tl9B-2ralA:
undetectable		 3tl9B-2ralA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		5 / 12 VAL A 559
ASN A 428
GLN A 425
ASN A 501
GLN A 451
 None
 1.44A 4kuoA-2ralA:
undetectable		 4kuoA-2ralA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		3 / 3 SER A 535
GLU A 510
ASP A 493
 None
 0.85A 4xudA-2ralA:
undetectable		 4xudA-2ralA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		4 / 4 VAL A 488
ILE A 453
ASN A 466
VAL A 526
 None
 1.16A 5ajqA-2ralA:
undetectable		 5ajqA-2ralA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		5 / 12 GLY A 492
GLN A 495
ASP A 511
VAL A 512
THR A 513
 None
 0.90A 5kocA-2ralA:
undetectable		 5kocA-2ralA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		5 / 12 GLY A 492
GLN A 495
ASP A 511
VAL A 512
THR A 513
 None
 0.98A 5kpcB-2ralA:
undetectable		 5kpcB-2ralA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		5 / 11 ASP A 482
VAL A 488
ILE A 486
THR A 484
ILE A 528
 None
 1.21A 5y80A-2ralA:
undetectable		 5y80A-2ralA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		3 / 3 GLY A 592
ASP A 351
ILE A 349
 None
 0.54A 6dgxB-2ralA:
undetectable		 6dgxB-2ralA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		5 / 12 LEU A 497
PHE A 530
VAL A 488
VAL A 467
TYR A 424
 None
 1.08A 6djzA-2ralA:
undetectable		 6djzA-2ralA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		5 / 12 LEU A 497
PHE A 530
VAL A 488
VAL A 467
TYR A 424
 None
 1.09A 6djzC-2ralA:
2.3		 6djzC-2ralA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		5 / 12 ILE A 346
GLY A 360
THR A 326
ILE A 331
ASP A 363
 None
 0.92A 6emuA-2ralA:
undetectable		 6emuA-2ralA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G
(Staphylococcus
epidermidis) 		5 / 12 ILE A 346
GLY A 360
THR A 326
ILE A 331
ASP A 363
 None
 0.84A 6emuB-2ralA:
undetectable		 6emuB-2ralA:
22.45