SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ran'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 2ran ANNEXIN V
(Rattus
norvegicus) 		4 / 5 TYR A 248
LEU A 279
THR A 266
ARG A 269
 None
 1.13A 1i2wA-2ranA:
undetectable		 1i2wA-2ranA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2ran ANNEXIN V
(Rattus
norvegicus) 		5 / 12 ALA A 237
THR A 252
ILE A 123
LEU A 120
ARG A 115
 None
 1.03A 1tw4A-2ranA:
undetectable		 1tw4A-2ranA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 2ran ANNEXIN V
(Rattus
norvegicus) 		4 / 5 GLU A 285
THR A 252
LEU A 253
LEU A 249
 None
 1.05A 1u18B-2ranA:
undetectable		 1u18B-2ranA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2ran ANNEXIN V
(Rattus
norvegicus) 		5 / 11 ILE A 219
GLY A 181
THR A 187
GLU A 182
LEU A 196
 None
CA  A 324 (-4.1A)
CA  A 324 ( 4.8A)
None
None
 1.23A 2fn1A-2ranA:
undetectable		 2fn1A-2ranA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2ran ANNEXIN V
(Rattus
norvegicus) 		4 / 6 THR A 227
GLU A 226
PHE A 217
ILE A 219
 None
CA  A 324 (-2.3A)
None
None
 1.40A 2w98B-2ranA:
undetectable		 2w98B-2ranA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 2ran ANNEXIN V
(Rattus
norvegicus) 		4 / 8 ILE A 219
ILE A 195
ALA A 176
VAL A 207
 None
 0.84A 4jltA-2ranA:
undetectable		 4jltA-2ranA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ran ANNEXIN V
(Rattus
norvegicus) 		4 / 7 LEU A  94
THR A 103
THR A 143
LEU A 151
 None
CA  A 322 (-3.9A)
None
None
 0.78A 4z91F-2ranA:
undetectable
4z91G-2ranA:
undetectable
4z91H-2ranA:
undetectable
4z91I-2ranA:
undetectable
4z91J-2ranA:
undetectable		 4z91F-2ranA:
21.13
4z91G-2ranA:
21.13
4z91H-2ranA:
21.13
4z91I-2ranA:
21.13
4z91J-2ranA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 2ran ANNEXIN V
(Rattus
norvegicus) 		4 / 6 ILE A 219
ALA A 174
LEU A 177
ILE A 195
 None
 0.85A 5mvmB-2ranA:
undetectable
5mvmC-2ranA:
undetectable		 5mvmB-2ranA:
12.50
5mvmC-2ranA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2ran ANNEXIN V
(Rattus
norvegicus) 		4 / 8 GLN A 218
VAL A 238
ARG A 243
ASP A 209
 None
 1.06A 6hu9a-2ranA:
undetectable
6hu9e-2ranA:
undetectable		 6hu9a-2ranA:
18.91
6hu9e-2ranA:
19.68