SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2raq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2raq CONSERVED PROTEIN
MTH889
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 LYS A  52
ILE A  69
THR A  48
 None
 0.85A 1rx3A-2raqA:
undetectable		 1rx3A-2raqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2raq CONSERVED PROTEIN
MTH889
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  60
LEU A   6
ILE A  55
ARG A   8
 None
 0.98A 2rlfC-2raqA:
undetectable
2rlfD-2raqA:
undetectable		 2rlfC-2raqA:
16.09
2rlfD-2raqA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2raq CONSERVED PROTEIN
MTH889
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 LYS A  52
ILE A  69
THR A  48
 None
 0.85A 4gh8A-2raqA:
undetectable		 4gh8A-2raqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2raq CONSERVED PROTEIN
MTH889
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ASP A  59
ASN A  58
ILE A   7
VAL A  37
ILE A  76
 None
 0.99A 4q5mA-2raqA:
undetectable		 4q5mA-2raqA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2raq CONSERVED PROTEIN
MTH889
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 ALA A  68
SER A  71
GLY A  73
TYR A  24
 None
 1.12A 5yodB-2raqA:
undetectable		 5yodB-2raqA:
20.99