SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ras'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)
2ras TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans)
4 / 7 PHE A 192
PRO A  83
ALA A 146
PHE A 147
None
0.92A 1lqtA-2rasA:
undetectable
1lqtA-2rasA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)
2ras TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans)
4 / 7 PHE A 192
PRO A  83
ALA A 146
PHE A 147
None
0.92A 1lquA-2rasA:
undetectable
1lquA-2rasA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)
2ras TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans)
5 / 12 LEU A 134
ASN A 160
LEU A 158
MET A  87
CYH A 167
None
EDO  A 216 ( 4.0A)
None
None
EDO  A 216 (-4.3A)
1.41A 1ya3A-2rasA:
undetectable
1ya3A-2rasA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)
2ras TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans)
5 / 12 LEU A 134
ASN A 160
LEU A 158
MET A  87
CYH A 167
None
EDO  A 216 ( 4.0A)
None
None
EDO  A 216 (-4.3A)
1.40A 2aa5B-2rasA:
undetectable
2aa5B-2rasA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)
2ras TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans)
5 / 12 LEU A 134
ASN A 160
LEU A 158
MET A  87
CYH A 167
None
EDO  A 216 ( 4.0A)
None
None
EDO  A 216 (-4.3A)
1.40A 2oaxA-2rasA:
undetectable
2oaxA-2rasA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)
2ras TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans)
5 / 12 LEU A 134
ASN A 160
LEU A 158
MET A  87
CYH A 167
None
EDO  A 216 ( 4.0A)
None
None
EDO  A 216 (-4.3A)
1.35A 2oaxE-2rasA:
undetectable
2oaxE-2rasA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)
2ras TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans)
4 / 6 GLU A 181
ARG A  99
LEU A 184
TYR A  88
None
1.07A 5phhA-2rasA:
undetectable
5phhA-2rasA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)
2ras TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans)
5 / 12 MET A  98
ALA A 168
GLU A 114
LEU A 109
VAL A 123
None
1.36A 5vlmC-2rasA:
4.6
5vlmC-2rasA:
23.01