SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rb4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2rb4 ATP-DEPENDENT RNA
HELICASE DDX25
(Homo
sapiens) 		4 / 5 ILE A 448
ILE A 409
ILE A 467
LEU A 354
 None
 0.93A 1zgyA-2rb4A:
undetectable		 1zgyA-2rb4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 2rb4 ATP-DEPENDENT RNA
HELICASE DDX25
(Homo
sapiens) 		4 / 4 VAL A 410
ALA A 444
ASN A 446
GLN A 314
 None
 1.40A 4zgfA-2rb4A:
undetectable		 4zgfA-2rb4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2rb4 ATP-DEPENDENT RNA
HELICASE DDX25
(Homo
sapiens) 		3 / 3 ARG A 431
PRO A 416
ASN A 446
 None
 1.01A 5jwaA-2rb4A:
undetectable
5jwaH-2rb4A:
undetectable		 5jwaA-2rb4A:
16.27
5jwaH-2rb4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 2rb4 ATP-DEPENDENT RNA
HELICASE DDX25
(Homo
sapiens) 		5 / 10 LEU A 456
LEU A 470
ASN A 412
LEU A 443
ALA A 444
 None
 1.04A 5y7pB-2rb4A:
undetectable		 5y7pB-2rb4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 2rb4 ATP-DEPENDENT RNA
HELICASE DDX25
(Homo
sapiens) 		5 / 10 LEU A 456
LEU A 470
ASN A 412
LEU A 443
ALA A 444
 None
 1.06A 5y7pD-2rb4A:
undetectable		 5y7pD-2rb4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2rb4 ATP-DEPENDENT RNA
HELICASE DDX25
(Homo
sapiens) 		5 / 10 LEU A 456
LEU A 470
ASN A 412
LEU A 443
ALA A 444
 None
 1.00A 5y7pH-2rb4A:
undetectable		 5y7pH-2rb4A:
20.30