SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 LEU A  61
LEU A  56
ILE A 251
THR A  25
ILE A 261
 None
 1.21A 1i18A-2rb5A:
undetectable
1i18B-2rb5A:
undetectable		 1i18A-2rb5A:
20.38
1i18B-2rb5A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 ILE A 261
LEU A  61
LEU A  56
ILE A 251
THR A  25
 None
 1.23A 1i18A-2rb5A:
undetectable
1i18B-2rb5A:
undetectable		 1i18A-2rb5A:
20.38
1i18B-2rb5A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TCT_A_CTCA222_0
(TETRACYCLINE
REPRESSOR)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 178
PRO A  46
GLN A 149
VAL A 107
ILE A 134
 None
 1.02A 2tctA-2rb5A:
0.2		 2tctA-2rb5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 126
PHE A 125
PHE A 153
ILE A 134
 None
 1.05A 2zseA-2rb5A:
undetectable		 2zseA-2rb5A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 VAL A  14
ASP A 211
ILE A  50
ASN A  52
 None
MG  A 701 (-2.5A)
None
None
 0.95A 3avpA-2rb5A:
undetectable		 3avpA-2rb5A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 GLU A 170
LYS A 184
PRO A  86
GLU A  89
 None
 1.13A 4a7tF-2rb5A:
undetectable		 4a7tF-2rb5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ARG A  45
PRO A  46
GLN A 149
VAL A 107
ILE A 134
 None
 1.34A 4b3aA-2rb5A:
0.0		 4b3aA-2rb5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 178
PRO A  46
GLN A 149
VAL A 107
ILE A 134
 None
 1.06A 4b3aA-2rb5A:
0.0		 4b3aA-2rb5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A  44
ASN A  69
MET A  68
ILE A  49
LEU A  53
 WO6  A 801 (-3.6A)
None
None
None
None
 1.49A 4koyA-2rb5A:
undetectable		 4koyA-2rb5A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 251
THR A  25
THR A  12
LEU A  29
LEU A  56
 None
 1.12A 4pbhA-2rb5A:
undetectable		 4pbhA-2rb5A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 9 SER A 208
ALA A  42
PHE A   7
SER A 217
LEU A 219
 None
 1.41A 4z69A-2rb5A:
undetectable		 4z69A-2rb5A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 133
TYR A  65
ILE A 195
PRO A  46
 None
 1.22A 4ze1A-2rb5A:
undetectable		 4ze1A-2rb5A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 219
LEU A  13
ILE A  39
THR A 243
ALA A 254
 None
 1.26A 5ienA-2rb5A:
undetectable		 5ienA-2rb5A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 9 ILE A 260
ALA A  32
ILE A 261
ILE A 251
ALA A 254
 None
 1.13A 5mvmA-2rb5A:
undetectable
5mvmE-2rb5A:
undetectable		 5mvmA-2rb5A:
14.62
5mvmE-2rb5A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 8 ILE A 251
ALA A 254
ILE A 260
ALA A  32
ILE A 261
 None
 1.03A 5mvmA-2rb5A:
undetectable
5mvmB-2rb5A:
undetectable		 5mvmA-2rb5A:
14.62
5mvmB-2rb5A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ASN A  69
ILE A  49
ILE A   9
VAL A 131
PHE A 178
 None
None
WO6  A 801 (-3.6A)
None
None
 1.29A 6j21A-2rb5A:
undetectable		 6j21A-2rb5A:
20.49