SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rb7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		4 / 7 ASP A 137
ASP A  74
TYR A 312
ARG A 311
 None
 1.33A 1cebA-2rb7A:
undetectable		 1cebA-2rb7A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		4 / 4 GLY A  94
LEU A  82
GLY A  96
ARG A  95
 None
 1.37A 1j7kA-2rb7A:
undetectable		 1j7kA-2rb7A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		5 / 12 ASN A 144
ILE A  53
ASP A  74
GLY A 136
ASP A 309
 None
 1.11A 1likA-2rb7A:
undetectable		 1likA-2rb7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		4 / 7 VAL A 269
GLY A 246
ILE A 231
THR A 208
 None
 0.67A 1t7iB-2rb7A:
undetectable		 1t7iB-2rb7A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		4 / 7 VAL A 269
GLY A 246
ILE A 231
THR A 208
 None
 0.70A 1t7jB-2rb7A:
undetectable		 1t7jB-2rb7A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		6 / 12 THR A  11
ILE A 346
GLY A 107
ILE A   7
VAL A 159
ALA A  71
 None
 1.31A 1vq1B-2rb7A:
undetectable		 1vq1B-2rb7A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		3 / 3 ASP A 100
GLU A 173
ARG A 277
 None
 0.75A 1wopA-2rb7A:
undetectable		 1wopA-2rb7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		3 / 3 THR A  11
GLU A 336
HIS A  72
 None
 0.72A 1xwfA-2rb7A:
1.7		 1xwfA-2rb7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		3 / 3 THR A  11
GLU A 336
HIS A  72
 None
 0.71A 1xwfB-2rb7A:
undetectable		 1xwfB-2rb7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		3 / 3 THR A  11
GLU A 336
HIS A  72
 None
 0.72A 1xwfC-2rb7A:
2.0		 1xwfC-2rb7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		3 / 3 THR A  11
GLU A 336
HIS A  72
 None
 0.73A 1xwfD-2rb7A:
undetectable		 1xwfD-2rb7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		5 / 5 LEU A 313
GLY A 320
THR A 290
ILE A 170
VAL A 169
 None
 1.40A 3wriA-2rb7A:
undetectable		 3wriA-2rb7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		5 / 5 LEU A 313
GLY A 320
THR A 290
ILE A 170
VAL A 169
 None
 1.39A 3wriB-2rb7A:
undetectable		 3wriB-2rb7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		3 / 3 SER A  55
MET A  57
ASP A 162
 None
PGE  A 364 ( 3.8A)
None
 0.93A 4mm4B-2rb7A:
undetectable		 4mm4B-2rb7A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		4 / 7 ILE A 250
PHE A 214
LEU A 261
ASP A 256
 None
 0.82A 4mmcA-2rb7A:
undetectable		 4mmcA-2rb7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		6 / 11 HIS A  72
ASP A  99
GLU A 138
GLU A 139
GLY A 306
HIS A 332
 None
 0.34A 4pqaA-2rb7A:
34.2		 4pqaA-2rb7A:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY
(Desulfovibrio
alaskensis) 		5 / 12 GLY A   0
GLN A   5
VAL A  87
ILE A 340
ASP A  90
 None
 1.00A 6bxnB-2rb7A:
undetectable		 6bxnB-2rb7A:
22.86