SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rb9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 8 ILE A 127
LEU A  32
MET A  24
GLU A  25
ALA A  26
 None
 1.07A 1a29A-2rb9A:
undetectable		 1a29A-2rb9A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 9 ILE A 127
LEU A  32
MET A  24
GLU A  25
ALA A  26
 None
 1.15A 1ctrA-2rb9A:
undetectable		 1ctrA-2rb9A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 6 LEU A 100
LEU A 104
PRO A 105
MET A 106
 None
 1.20A 1hz4A-2rb9A:
undetectable		 1hz4A-2rb9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 6 ALA A 117
ILE A  77
SER A 115
CYH A  96
 None
 1.00A 1sbrA-2rb9A:
undetectable
1sbrB-2rb9A:
1.8		 1sbrA-2rb9A:
21.84
1sbrB-2rb9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 12 PHE A  27
ALA A  26
LEU A 109
LEU A  22
ILE A  19
 None
 1.01A 1xdkF-2rb9A:
undetectable		 1xdkF-2rb9A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 8 LEU A 170
VAL A 312
LEU A 314
VAL A 172
 None
 1.01A 2bdmA-2rb9A:
undetectable		 2bdmA-2rb9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 176
ASN A 271
VAL A 255
ALA A 266
 None
 1.00A 2cizA-2rb9A:
undetectable		 2cizA-2rb9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 8 ARG A 220
GLY A 160
ALA A 218
LYS A 217
 None
 0.95A 2xh9A-2rb9A:
undetectable		 2xh9A-2rb9A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 10 ALA A 290
LEU A 203
LEU A 275
LEU A 210
LEU A 206
 None
 1.17A 2xn6A-2rb9A:
undetectable
2xn6B-2rb9A:
undetectable		 2xn6A-2rb9A:
23.58
2xn6B-2rb9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 9 VAL A 231
GLY A 311
GLY A 241
ILE A 244
LEU A 324
 None
 0.91A 2z0yA-2rb9A:
undetectable		 2z0yA-2rb9A:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 5 TYR A  93
ARG A  92
MET A 150
LEU A  53
 None
 1.28A 3ag2J-2rb9A:
undetectable		 3ag2J-2rb9A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 5 TYR A  93
ARG A  92
MET A 150
LEU A  53
 None
 1.30A 3ag4J-2rb9A:
undetectable		 3ag4J-2rb9A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 10 ALA A  81
ILE A  90
GLY A 151
ALA A 126
ILE A 125
 None
 0.99A 3ekwA-2rb9A:
undetectable		 3ekwA-2rb9A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 10 ARG A 334
ASP A 199
GLY A  69
GLY A  70
ILE A 183
 None
 0.99A 3em4V-2rb9A:
undetectable		 3em4V-2rb9A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 6 VAL A 306
LEU A 210
ALA A 278
LEU A 170
 None
 0.85A 3kk6B-2rb9A:
undetectable		 3kk6B-2rb9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 7 ALA A 266
VAL A 172
VAL A 227
LEU A 267
 None
 0.87A 3o14A-2rb9A:
undetectable		 3o14A-2rb9A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 12 PHE A  27
ALA A  26
LEU A 109
LEU A  22
ILE A  19
 None
 1.11A 4dm8B-2rb9A:
undetectable		 4dm8B-2rb9A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 7 ILE A 169
LEU A 170
LYS A 310
GLY A 241
 None
 1.06A 4hc3A-2rb9A:
undetectable		 4hc3A-2rb9A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 192
LEU A 262
ILE A 183
ILE A 335
HIS A 179
 None
 1.29A 4j26B-2rb9A:
undetectable		 4j26B-2rb9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_B_SAMB603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 9 LEU A 176
ASP A 199
VAL A 255
THR A 182
ILE A 183
 None
 1.21A 4pcuA-2rb9A:
0.0
4pcuB-2rb9A:
0.0		 4pcuA-2rb9A:
22.06
4pcuB-2rb9A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 8 LEU A 267
VAL A 231
VAL A 172
LEU A 324
 None
 1.04A 4puoC-2rb9A:
2.0		 4puoC-2rb9A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		6 / 12 LEU A 275
LEU A 219
ILE A 207
ILE A 157
VAL A 287
LEU A 291
 None
 1.33A 4y0sA-2rb9A:
undetectable		 4y0sA-2rb9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 7 ASN A 228
VAL A 231
ALA A 235
GLY A 311
 None
 0.72A 5fpdB-2rb9A:
undetectable		 5fpdB-2rb9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 275
ILE A 303
GLY A 304
ARG A 220
LEU A 219
 None
 1.10A 5h5fA-2rb9A:
undetectable		 5h5fA-2rb9A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 12 LEU A  32
ILE A 127
VAL A 113
ASP A 131
PHE A  98
 None
 1.15A 5vlmG-2rb9A:
undetectable		 5vlmG-2rb9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 5 TYR A  93
ARG A  92
MET A 150
LEU A  53
 None
 1.40A 5x19J-2rb9A:
undetectable		 5x19J-2rb9A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 5 TYR A  93
ARG A  92
MET A 150
LEU A  53
 None
 1.43A 5x1bJ-2rb9A:
undetectable		 5x1bJ-2rb9A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 5 TYR A  93
ARG A  92
MET A 150
LEU A  53
 None
 1.29A 5x1bW-2rb9A:
undetectable		 5x1bW-2rb9A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 11 GLU A  49
ARG A  92
ALA A  85
ILE A 157
ARG A 211
 None
 1.17A 5yk2A-2rb9A:
undetectable		 5yk2A-2rb9A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 12 GLY A  79
GLY A 149
ASP A 199
CYH A 200
ASP A  58
 None
 0.99A 5yn6A-2rb9A:
undetectable		 5yn6A-2rb9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 12 GLY A  79
GLY A 149
ASP A 199
CYH A 200
ASP A  58
 None
 0.99A 5yniA-2rb9A:
undetectable		 5yniA-2rb9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		5 / 12 GLY A  79
GLY A 149
ASP A 199
CYH A 200
ASP A  58
 None
 0.98A 5ynmA-2rb9A:
undetectable		 5ynmA-2rb9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 8 LEU A 196
LEU A 192
LEU A 264
GLY A 263
 None
 0.90A 6ce2A-2rb9A:
undetectable		 6ce2A-2rb9A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		3 / 3 ILE A 183
THR A 182
PRO A  64
 None
 0.64A 6ncsA-2rb9A:
undetectable		 6ncsA-2rb9A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rb9 HYPE PROTEIN
(Escherichia
coli) 		4 / 5 TYR A  93
ARG A  92
MET A 150
LEU A  53
 None
 1.34A 6nknJ-2rb9A:
undetectable		 6nknJ-2rb9A:
13.24