SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2rc3 CBS DOMAIN
(Nitrosomonas
europaea) 		7 / 12 ILE A  72
THR A  74
ASP A  77
LYS A  81
THR A  99
VAL A 102
PRO A 127
 None
BR  A 171 (-4.0A)
None
None
BR  A 177 ( 4.2A)
None
None
 0.80A 3kpbA-2rc3A:
18.0		 3kpbA-2rc3A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2rc3 CBS DOMAIN
(Nitrosomonas
europaea) 		8 / 12 HIS A 125
ILE A  72
THR A  74
ASP A  77
LYS A  81
THR A  99
VAL A 102
PRO A 127
 NAD  A1000 (-3.9A)
None
BR  A 171 (-4.0A)
None
None
BR  A 177 ( 4.2A)
None
None
 0.85A 3kpbC-2rc3A:
17.9		 3kpbC-2rc3A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2rc3 CBS DOMAIN
(Nitrosomonas
europaea) 		6 / 10 ILE A  72
THR A  74
ASP A  77
LYS A  81
THR A  99
VAL A 102
 None
BR  A 171 (-4.0A)
None
None
BR  A 177 ( 4.2A)
None
 0.83A 3kpbD-2rc3A:
17.7		 3kpbD-2rc3A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2rc3 CBS DOMAIN
(Nitrosomonas
europaea) 		6 / 11 ILE A  72
THR A  74
ASP A  77
THR A  99
VAL A 102
PRO A 127
 None
BR  A 171 (-4.0A)
None
BR  A 177 ( 4.2A)
None
None
 0.64A 3kpcA-2rc3A:
18.2		 3kpcA-2rc3A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2rc3 CBS DOMAIN
(Nitrosomonas
europaea) 		7 / 12 ILE A  72
THR A  74
ASP A  77
LYS A  81
THR A  99
VAL A 102
PRO A 127
 None
BR  A 171 (-4.0A)
None
None
BR  A 177 ( 4.2A)
None
None
 0.84A 3kpdB-2rc3A:
18.3		 3kpdB-2rc3A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2rc3 CBS DOMAIN
(Nitrosomonas
europaea) 		6 / 12 ILE A  72
THR A  74
ASP A  77
THR A  99
VAL A 102
PRO A 127
 None
BR  A 171 (-4.0A)
None
BR  A 177 ( 4.2A)
None
None
 0.67A 3kpdC-2rc3A:
17.7		 3kpdC-2rc3A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2rc3 CBS DOMAIN
(Nitrosomonas
europaea) 		3 / 3 ARG A 124
VAL A 102
THR A  99
 BR  A 171 (-4.4A)
None
BR  A 177 ( 4.2A)
 0.85A 3nduD-2rc3A:
undetectable		 3nduD-2rc3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2rc3 CBS DOMAIN
(Nitrosomonas
europaea) 		3 / 3 ARG A 124
VAL A 102
THR A  99
 BR  A 171 (-4.4A)
None
BR  A 177 ( 4.2A)
 0.85A 3pwrA-2rc3A:
undetectable		 3pwrA-2rc3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2rc3 CBS DOMAIN
(Nitrosomonas
europaea) 		3 / 3 ARG A 124
VAL A 102
THR A  99
 BR  A 171 (-4.4A)
None
BR  A 177 ( 4.2A)
 0.88A 3tl9A-2rc3A:
undetectable		 3tl9A-2rc3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2rc3 CBS DOMAIN
(Nitrosomonas
europaea) 		5 / 12 LEU A 137
THR A  99
GLU A  75
ALA A  60
THR A  74
 NAD  A1000 (-3.9A)
BR  A 177 ( 4.2A)
None
NAD  A1000 (-4.0A)
BR  A 171 (-4.0A)
 1.22A 4fiaA-2rc3A:
undetectable		 4fiaA-2rc3A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2rc3 CBS DOMAIN
(Nitrosomonas
europaea) 		5 / 12 LEU A 137
THR A  99
GLU A  75
ALA A  60
THR A  74
 NAD  A1000 (-3.9A)
BR  A 177 ( 4.2A)
None
NAD  A1000 (-4.0A)
BR  A 171 (-4.0A)
 1.22A 4fiaA-2rc3A:
undetectable		 4fiaA-2rc3A:
14.47