SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rc5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		5 / 12 GLY A 267
GLY A 266
GLY A 265
SER A 165
ASN A 198
 None
 0.82A 1xdsA-2rc5A:
4.3		 1xdsA-2rc5A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		5 / 10 LEU A 263
ALA A 258
ILE A 262
VAL A 252
PHE A 269
 None
 1.08A 1xp0A-2rc5A:
undetectable		 1xp0A-2rc5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		4 / 5 TYR A  96
PRO A 179
THR A 150
SER A 153
 FAD  A 415 (-4.0A)
None
None
None
 1.33A 1ymxA-2rc5A:
undetectable		 1ymxA-2rc5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		5 / 9 LEU A 309
LEU A 303
PHE A 269
LEU A 171
ILE A 271
 None
 1.25A 2f7aB-2rc5A:
undetectable		 2f7aB-2rc5A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		4 / 8 MET A 169
LEU A 171
ARG A 251
SER A 184
 None
 1.16A 2qd2A-2rc5A:
2.7		 2qd2A-2rc5A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		4 / 6 GLU A 285
MET A 169
PHE A 269
ILE A 271
 None
 1.35A 2w98B-2rc5A:
4.1		 2w98B-2rc5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		5 / 12 ILE A 283
GLU A 304
SER A  97
ALA A 178
ILE A 271
 None
None
FAD  A 415 (-3.1A)
FAD  A 415 ( 3.9A)
None
 1.20A 2xkwB-2rc5A:
undetectable		 2xkwB-2rc5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		3 / 3 GLY A 176
GLY A 204
GLY A 174
 None
 0.41A 3bogC-2rc5A:
undetectable		 3bogC-2rc5A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		4 / 8 GLY A 176
CYH A 134
MET A 138
CYH A 139
 None
FAD  A 415 (-4.9A)
None
None
 0.70A 3ko0D-2rc5A:
undetectable
3ko0E-2rc5A:
undetectable		 3ko0D-2rc5A:
16.09
3ko0E-2rc5A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		4 / 8 GLY A 273
CYH A 134
MET A 138
CYH A 139
 None
FAD  A 415 (-4.9A)
None
None
 0.89A 3ko0D-2rc5A:
undetectable
3ko0E-2rc5A:
undetectable		 3ko0D-2rc5A:
16.09
3ko0E-2rc5A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		4 / 8 GLY A 176
CYH A 134
MET A 138
CYH A 139
 None
FAD  A 415 (-4.9A)
None
None
 0.79A 3ko0B-2rc5A:
undetectable
3ko0J-2rc5A:
undetectable		 3ko0B-2rc5A:
16.09
3ko0J-2rc5A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		4 / 8 GLY A 273
CYH A 134
MET A 138
CYH A 139
 None
FAD  A 415 (-4.9A)
None
None
 0.87A 3ko0B-2rc5A:
undetectable
3ko0J-2rc5A:
undetectable		 3ko0B-2rc5A:
16.09
3ko0J-2rc5A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		5 / 12 LEU A  32
LEU A 217
THR A 175
ILE A 177
ALA A 178
 None
None
FAD  A 415 (-3.4A)
None
FAD  A 415 ( 3.9A)
 0.55A 3mdvB-2rc5A:
undetectable		 3mdvB-2rc5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		3 / 3 TYR A 203
GLU A 236
TYR A 207
 None
 0.94A 3ug8A-2rc5A:
undetectable		 3ug8A-2rc5A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		4 / 5 GLU A 210
SER A 208
ARG A  41
PRO A 206
 None
 1.13A 4k17B-2rc5A:
undetectable		 4k17B-2rc5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		4 / 6 MET A 183
ILE A 283
ILE A 286
VAL A 282
 None
 0.91A 4olmA-2rc5A:
undetectable		 4olmA-2rc5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		5 / 12 ILE A 193
ARG A 268
LEU A 159
LEU A 220
LEU A 188
 None
 1.40A 4qynB-2rc5A:
undetectable		 4qynB-2rc5A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		5 / 12 PHE A 164
ILE A 168
GLY A 166
GLY A 266
HIS A 301
 None
 1.09A 5eqbA-2rc5A:
undetectable		 5eqbA-2rc5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		5 / 12 VAL A  26
ALA A  24
ILE A 112
SER A 100
PHE A 114
 None
 1.24A 5hgcA-2rc5A:
undetectable		 5hgcA-2rc5A:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		7 / 9 SER A  97
THR A 175
GLY A 176
ALA A 178
CYH A 272
GLY A 273
GLU A 312
 FAD  A 415 (-3.1A)
FAD  A 415 (-3.4A)
None
FAD  A 415 ( 3.9A)
None
None
FAD  A 415 (-3.8A)
 0.59A 5vw4A-2rc5A:
35.6		 5vw4A-2rc5A:
37.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		6 / 8 SER A  97
THR A 175
GLY A 176
CYH A 272
GLY A 273
GLU A 312
 FAD  A 415 (-3.1A)
FAD  A 415 (-3.4A)
None
None
None
FAD  A 415 (-3.8A)
 0.65A 5vw5A-2rc5A:
34.9		 5vw5A-2rc5A:
37.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2rc5 FERREDOXIN-NADP
REDUCTASE
(Leptospira
interrogans) 		7 / 8 SER A  97
THR A 175
GLY A 176
ALA A 178
CYH A 272
GLY A 273
GLU A 312
 FAD  A 415 (-3.1A)
FAD  A 415 (-3.4A)
None
FAD  A 415 ( 3.9A)
None
None
FAD  A 415 (-3.8A)
 0.55A 5vw9A-2rc5A:
35.2		 5vw9A-2rc5A:
37.28