SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rcb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 5 THR A  11
THR A 120
THR A 201
HIS A  15
 None
 1.37A 1d4fB-2rcbA:
undetectable		 1d4fB-2rcbA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 6 LEU A  74
TYR A 271
ARG A 270
LEU A 264
 None
 1.02A 2dyrA-2rcbA:
undetectable
2dyrJ-2rcbA:
undetectable		 2dyrA-2rcbA:
21.58
2dyrJ-2rcbA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 6 LEU A  74
TYR A 271
ARG A 270
LEU A 264
 None
 1.04A 2dysA-2rcbA:
undetectable
2dysJ-2rcbA:
undetectable		 2dysA-2rcbA:
21.58
2dysJ-2rcbA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 7 LEU A  74
TYR A 271
ARG A 270
LEU A 264
 None
 1.08A 2eikA-2rcbA:
undetectable
2eikJ-2rcbA:
undetectable		 2eikA-2rcbA:
21.58
2eikJ-2rcbA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 4 ARG A  99
GLY A 105
GLU A 176
SER A  43
 None
 1.29A 2xctS-2rcbA:
undetectable
2xctU-2rcbA:
undetectable		 2xctS-2rcbA:
18.37
2xctU-2rcbA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 6 LEU A  74
TYR A 271
ARG A 270
LEU A 264
 None
 1.07A 2zxwA-2rcbA:
undetectable
2zxwJ-2rcbA:
undetectable		 2zxwA-2rcbA:
21.58
2zxwJ-2rcbA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 6 LEU A  74
TYR A 271
ARG A 270
LEU A 264
 None
 0.97A 3abmA-2rcbA:
undetectable
3abmJ-2rcbA:
undetectable		 3abmA-2rcbA:
21.58
3abmJ-2rcbA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 6 LEU A  74
TYR A 271
ARG A 270
LEU A 264
 None
 1.05A 3asnA-2rcbA:
undetectable
3asnJ-2rcbA:
undetectable		 3asnA-2rcbA:
21.58
3asnJ-2rcbA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 6 LEU A  74
TYR A 271
ARG A 270
LEU A 264
 None
 1.04A 3asoA-2rcbA:
undetectable
3asoJ-2rcbA:
undetectable		 3asoA-2rcbA:
21.58
3asoJ-2rcbA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		5 / 12 ASP A  92
PHE A 122
ARG A   8
GLY A 108
LEU A 110
 None
None
GOL  A 902 ( 4.1A)
None
None
 1.29A 3j6pB-2rcbA:
undetectable		 3j6pB-2rcbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 8 ILE A 124
PRO A 137
SER A 140
GLY A 249
 None
 0.62A 3lslA-2rcbA:
30.3
3lslD-2rcbA:
30.0		 3lslA-2rcbA:
29.63
3lslD-2rcbA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 8 ILE A 124
PRO A 137
SER A 140
GLY A 249
 None
 0.72A 3lslA-2rcbA:
30.3
3lslD-2rcbA:
30.0		 3lslA-2rcbA:
29.63
3lslD-2rcbA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 7 ASP A 222
SER A 123
TYR A 250
ARG A 128
 DSN  A 901 (-3.0A)
DSN  A 901 (-2.7A)
DSN  A 901 (-4.7A)
DSN  A 901 (-3.0A)
 0.94A 3pglA-2rcbA:
undetectable		 3pglA-2rcbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 6 TYR A 182
MET A 194
ILE A 183
SER A 142
 None
 0.97A 3pmzD-2rcbA:
undetectable		 3pmzD-2rcbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		3 / 3 TYR A 250
ASP A 227
ASP A 222
 DSN  A 901 (-4.7A)
None
DSN  A 901 (-3.0A)
 0.84A 3r24A-2rcbA:
undetectable		 3r24A-2rcbA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		5 / 12 PHE A  83
ALA A 115
VAL A 119
LEU A  73
LEU A 264
 None
 1.22A 3s79A-2rcbA:
undetectable		 3s79A-2rcbA:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 5 ILE A 124
PRO A 137
SER A 121
GLY A 251
 None
 1.14A 3tkdB-2rcbA:
30.3		 3tkdB-2rcbA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		5 / 12 GLY A 144
LEU A 225
LEU A 226
ALA A 246
TYR A  95
 None
None
None
None
DSN  A 901 (-3.3A)
 1.10A 4lg1B-2rcbA:
undetectable		 4lg1B-2rcbA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		5 / 12 GLY A 144
LEU A 225
LEU A 226
ALA A 246
TYR A  95
 None
None
None
None
DSN  A 901 (-3.3A)
 1.15A 4lg1C-2rcbA:
undetectable		 4lg1C-2rcbA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 8 ILE A 157
GLY A 144
THR A 141
SER A 123
 None
None
None
DSN  A 901 (-2.7A)
 0.83A 4r20A-2rcbA:
undetectable		 4r20A-2rcbA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		5 / 12 PHE A  83
ALA A 115
VAL A 119
LEU A  73
LEU A 264
 None
 1.23A 5jkvA-2rcbA:
undetectable		 5jkvA-2rcbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 6 LEU A  74
TYR A 271
ARG A 270
LEU A 264
 None
 1.05A 5x1fA-2rcbA:
undetectable
5x1fJ-2rcbA:
undetectable		 5x1fA-2rcbA:
21.58
5x1fJ-2rcbA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 7 LEU A  74
TYR A 271
ARG A 270
LEU A 264
 None
 0.98A 5xdxA-2rcbA:
undetectable
5xdxJ-2rcbA:
undetectable		 5xdxA-2rcbA:
21.58
5xdxJ-2rcbA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 6 ALA A 127
GLN A 130
GLN A 256
ASP A 133
 None
 1.25A 5y9aA-2rcbA:
undetectable		 5y9aA-2rcbA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 6 TYR A  95
VAL A  10
VAL A 119
THR A 120
 DSN  A 901 (-3.3A)
None
None
None
 1.31A 6f32B-2rcbA:
undetectable		 6f32B-2rcbA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 8 HIS A 158
GLY A 156
LEU A 143
GLY A 144
 None
 0.63A 6mdqA-2rcbA:
undetectable		 6mdqA-2rcbA:
16.67