SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rcc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		3 / 3 GLU A 185
HIS A 222
ASP A  93
 None
 0.81A 1i9gA-2rccA:
undetectable		 1i9gA-2rccA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 8 SER A  27
SER A  15
ASN A  16
ASP A 104
THR A  19
 None
 1.33A 1ig3A-2rccA:
undetectable
1ig3B-2rccA:
undetectable		 1ig3A-2rccA:
23.80
1ig3B-2rccA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		4 / 7 ASP A 104
SER A  27
SER A  15
ASN A  16
 None
 1.19A 1ig3A-2rccA:
undetectable
1ig3B-2rccA:
undetectable		 1ig3A-2rccA:
23.80
1ig3B-2rccA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		4 / 7 GLU A   2
LEU A   4
LEU A 240
GLU A 239
 None
 0.97A 1linA-2rccA:
undetectable		 1linA-2rccA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		7 / 11 GLU A 118
HIS A 121
LEU A 184
GLU A 185
TYR A 190
PHE A 193
ILE A 215
 None
 1.06A 1rnrA-2rccA:
31.1		 1rnrA-2rccA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		6 / 11 HIS A 121
LEU A 184
GLU A 185
PHE A 193
ILE A 215
GLU A 219
 None
 1.31A 1rnrA-2rccA:
31.1		 1rnrA-2rccA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		6 / 12 GLU A 118
HIS A 121
GLU A 185
TYR A 190
PHE A 193
ILE A 215
 None
 0.91A 1rnrB-2rccA:
31.4		 1rnrB-2rccA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 12 GLU A 118
HIS A 121
TYR A 125
GLU A 185
ILE A 215
 None
 0.59A 1rnrB-2rccA:
31.4		 1rnrB-2rccA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 12 GLU A 118
LEU A 184
TYR A 190
PHE A 193
ILE A 215
 None
 1.00A 1rnrB-2rccA:
31.4		 1rnrB-2rccA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 12 HIS A 121
GLU A 185
PHE A 193
ILE A 215
GLU A 219
 None
 1.25A 1rnrB-2rccA:
31.4		 1rnrB-2rccA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 12 HIS A 121
TYR A 125
GLU A 185
ILE A 215
GLU A 219
 None
 1.19A 1rnrB-2rccA:
31.4		 1rnrB-2rccA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		4 / 7 SER A 124
ILE A  80
ILE A  81
THR A 208
 None
 0.88A 1sbrB-2rccA:
undetectable		 1sbrB-2rccA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		4 / 6 TRP A 263
TYR A 266
ILE A 267
LEU A 151
 None
PG4  A 346 ( 3.8A)
PG4  A 346 ( 4.8A)
None
 0.81A 1xvaA-2rccA:
undetectable
1xvaB-2rccA:
undetectable		 1xvaA-2rccA:
21.07
1xvaB-2rccA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 12 ILE A 267
ILE A 268
ALA A  76
ILE A 212
MET A 309
 PG4  A 346 ( 4.8A)
None
None
None
None
 1.25A 1xzxX-2rccA:
3.1		 1xzxX-2rccA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 10 ALA A  40
LEU A 233
SER A 106
LEU A 107
ARG A  36
 None
 1.31A 2ceoB-2rccA:
undetectable		 2ceoB-2rccA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		3 / 3 PHE A 142
SER A 130
SER A 126
 None
 1.02A 3ufgB-2rccA:
undetectable		 3ufgB-2rccA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 12 ILE A 183
LEU A 187
ALA A 288
ILE A 178
LEU A 295
 None
 1.05A 3vrmA-2rccA:
undetectable		 3vrmA-2rccA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 12 LEU A  30
MET A 111
LEU A 110
ILE A 229
LEU A 225
 None
 0.96A 4j24D-2rccA:
3.3		 4j24D-2rccA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		3 / 3 SER A 124
ASP A 181
ASP A 218
 None
 0.75A 4uckA-2rccA:
undetectable		 4uckA-2rccA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		3 / 3 ASP A 258
SER A 285
TYR A 301
 None
 0.89A 5glmA-2rccA:
undetectable		 5glmA-2rccA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		4 / 5 LEU A 110
LEU A 107
MET A  96
GLN A 117
 None
 1.46A 5uc3A-2rccA:
3.1		 5uc3A-2rccA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 11 LEU A  84
SER A 124
PHE A 193
ILE A 212
ILE A 215
 None
 0.71A 6ebzA-2rccA:
27.5		 6ebzA-2rccA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 11 LEU A  84
SER A 124
PHE A 193
ILE A 212
ILE A 215
 None
 0.71A 6ebzB-2rccA:
27.6		 6ebzB-2rccA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 11 LEU A  84
SER A 124
PHE A 193
ILE A 212
ILE A 215
 None
 0.75A 6ebzD-2rccA:
27.6		 6ebzD-2rccA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 11 LEU A  84
SER A 124
PHE A 193
ILE A 212
ILE A 215
 None
 0.85A 6gp2A-2rccA:
27.4		 6gp2A-2rccA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		5 / 11 LEU A  84
SER A 124
PHE A 193
ILE A 212
ILE A 215
 None
 0.90A 6gp2B-2rccA:
27.4		 6gp2B-2rccA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA
(Bacillus
halodurans) 		3 / 3 ASP A 139
SER A 126
SER A 130
 None
 0.60A 6mxtA-2rccA:
1.4		 6mxtA-2rccA:
23.01