SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_A_NCAA303_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		5 / 9 HIS A 342
LEU A 513
SER A 512
ASP A 496
PHE A 489
 None
 1.20A 1ismA-2rchA:
0.0		 1ismA-2rchA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		5 / 7 HIS A 342
LEU A 513
SER A 512
ASP A 496
PHE A 489
 None
 1.18A 1ismB-2rchA:
undetectable		 1ismB-2rchA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		4 / 6 ASP A 398
LEU A 399
VAL A 400
ILE A 401
 None
 0.99A 1s9qA-2rchA:
undetectable		 1s9qA-2rchA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		3 / 3 LEU A 221
PHE A 220
ARG A 179
 None
 0.84A 1xdkB-2rchA:
undetectable		 1xdkB-2rchA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		3 / 3 LEU A 221
PHE A 220
ARG A 179
 None
 0.84A 1xdkF-2rchA:
undetectable		 1xdkF-2rchA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		3 / 3 GLY A 458
GLU A 462
ASN A 457
 None
None
HEM  A 600 (-4.2A)
 0.70A 1zq9A-2rchA:
undetectable		 1zq9A-2rchA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		5 / 8 TYR A 190
GLY A 210
GLY A 215
THR A 216
ALA A 217
 None
 1.48A 2ej3C-2rchA:
0.2		 2ej3C-2rchA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		4 / 7 LEU A 297
ILE A 153
SER A 155
TYR A 286
 None
None
HEM  A 600 (-3.6A)
None
 0.77A 2hc4A-2rchA:
1.5		 2hc4A-2rchA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		3 / 3 LYS A 133
GLY A 458
PRO A 459
 HEM  A 600 (-2.9A)
None
None
 0.75A 2hreB-2rchA:
undetectable		 2hreB-2rchA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		5 / 12 ALA A  81
TYR A 417
PRO A 421
GLY A 418
LEU A 116
 None
 0.98A 2nv4A-2rchA:
undetectable		 2nv4A-2rchA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		5 / 12 ALA A  81
TYR A 417
PRO A 421
GLY A 418
LEU A 116
 None
 1.00A 2nv4B-2rchA:
undetectable		 2nv4B-2rchA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		5 / 10 ALA A 293
LEU A 175
LEU A 171
LEU A 314
LEU A 174
 None
HEM  A 600 ( 4.9A)
HEM  A 600 (-3.7A)
None
None
 1.20A 2riwA-2rchA:
undetectable
2riwB-2rchA:
undetectable		 2riwA-2rchA:
19.42
2riwB-2rchA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		4 / 8 SER A 512
HIS A 345
SER A 494
ARG A 514
 None
 1.31A 2vmyA-2rchA:
undetectable
2vmyB-2rchA:
undetectable		 2vmyA-2rchA:
21.88
2vmyB-2rchA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		4 / 7 LEU A 348
ALA A 340
GLY A 338
PHE A 489
 None
 0.85A 2wq5A-2rchA:
undetectable		 2wq5A-2rchA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		4 / 6 LEU A 285
ILE A 243
ILE A 257
LEU A 273
 None
 0.87A 2xkwB-2rchA:
undetectable		 2xkwB-2rchA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		4 / 8 HIS A 452
ASP A 405
ASP A 426
ASP A 118
 None
 1.03A 3n2oC-2rchA:
undetectable
3n2oD-2rchA:
undetectable		 3n2oC-2rchA:
22.40
3n2oD-2rchA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		5 / 12 LEU A 285
ARG A 284
GLY A 215
THR A 216
LEU A 235
 None
 1.29A 3okxA-2rchA:
undetectable		 3okxA-2rchA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		3 / 3 PHE A 484
GLN A 187
PHE A 209
 None
 0.84A 3rv5A-2rchA:
0.0		 3rv5A-2rchA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		5 / 11 LEU A 449
ASP A 426
GLY A 119
PHE A 122
ALA A 433
 None
 1.17A 4fogD-2rchA:
undetectable		 4fogD-2rchA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		3 / 3 SER A 213
TYR A 190
PRO A 240
 None
 0.99A 4k8cA-2rchA:
undetectable		 4k8cA-2rchA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		3 / 3 SER A 213
TYR A 190
PRO A 240
 None
 0.97A 4kanB-2rchA:
undetectable		 4kanB-2rchA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		3 / 3 SER A 213
TYR A 190
PRO A 240
 None
 0.97A 4kbeA-2rchA:
undetectable		 4kbeA-2rchA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		5 / 12 LEU A 201
ASN A 346
HIS A 345
PHE A 194
ILE A 488
 None
 1.43A 5dv4A-2rchA:
undetectable		 5dv4A-2rchA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		4 / 5 GLU A 200
GLY A 210
SER A 212
GLY A 215
 None
 1.04A 5kprA-2rchA:
undetectable		 5kprA-2rchA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		5 / 12 GLY A 324
LEU A 147
TRP A 246
THR A 138
TYR A 141
 243  A 601 (-3.8A)
None
None
None
None
 1.29A 5nknA-2rchA:
0.0		 5nknA-2rchA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		4 / 5 MET A 142
TYR A 151
GLY A 150
GLY A 149
 None
 1.20A 5x7pA-2rchA:
undetectable		 5x7pA-2rchA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		5 / 12 ILE A 497
PHE A 495
LEU A 197
PHE A 209
PHE A 484
 None
 1.24A 6dwnB-2rchA:
28.4		 6dwnB-2rchA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2rch CYTOCHROME P450 74A
(Arabidopsis
thaliana) 		3 / 3 LEU A 513
SER A 511
PHE A 510
 None
 0.67A 6fgcA-2rchA:
undetectable		 6fgcA-2rchA:
21.77