SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 12 ILE A 186
ALA A  57
THR A 180
ILE A 126
LEU A 122
 ILE  A 186 ( 0.7A)
ALA  A  57 ( 0.0A)
THR  A 180 ( 0.8A)
ILE  A 126 ( 0.6A)
LEU  A 122 ( 0.6A)
 1.09A 1dhfA-2rciA:
undetectable		 1dhfA-2rciA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 12 ILE A 186
ALA A  57
THR A 180
ILE A 126
LEU A 122
 ILE  A 186 ( 0.7A)
ALA  A  57 ( 0.0A)
THR  A 180 ( 0.8A)
ILE  A 126 ( 0.6A)
LEU  A 122 ( 0.6A)
 1.16A 1dhfB-2rciA:
undetectable		 1dhfB-2rciA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		4 / 4 THR A  95
LEU A 220
LEU A  60
GLN A  56
 THR  A  95 ( 0.8A)
LEU  A 220 ( 0.6A)
LEU  A  60 ( 0.5A)
GLN  A  56 ( 0.6A)
 0.74A 1fbmA-2rciA:
undetectable		 1fbmA-2rciA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		4 / 5 THR A  95
LEU A 220
LEU A  60
GLN A  56
 THR  A  95 ( 0.8A)
LEU  A 220 ( 0.6A)
LEU  A  60 ( 0.5A)
GLN  A  56 ( 0.6A)
 0.74A 1fbmE-2rciA:
undetectable		 1fbmE-2rciA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 10 ALA A  57
THR A 180
ILE A 126
LEU A 122
THR A  61
 ALA  A  57 ( 0.0A)
THR  A 180 ( 0.8A)
ILE  A 126 ( 0.6A)
LEU  A 122 ( 0.6A)
THR  A  61 ( 0.8A)
 1.23A 2w3aB-2rciA:
undetectable		 2w3aB-2rciA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 10 ILE A 186
ALA A  57
THR A 180
ILE A 126
LEU A 122
 ILE  A 186 ( 0.7A)
ALA  A  57 ( 0.0A)
THR  A 180 ( 0.8A)
ILE  A 126 ( 0.6A)
LEU  A 122 ( 0.6A)
 1.12A 2w3aB-2rciA:
undetectable		 2w3aB-2rciA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 11 ILE A 111
ALA A 138
ILE A 114
ILE A 193
PHE A 143
 ILE  A 111 ( 0.7A)
ALA  A 138 ( 0.0A)
ILE  A 114 ( 0.7A)
ILE  A 193 ( 0.6A)
PHE  A 143 ( 1.3A)
 1.07A 2w9sA-2rciA:
undetectable		 2w9sA-2rciA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 11 ILE A 111
ALA A 138
ILE A 114
ILE A 193
PHE A 143
 ILE  A 111 ( 0.7A)
ALA  A 138 ( 0.0A)
ILE  A 114 ( 0.7A)
ILE  A 193 ( 0.6A)
PHE  A 143 ( 1.3A)
 1.08A 2w9sB-2rciA:
undetectable		 2w9sB-2rciA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 10 ILE A 111
ALA A 138
ILE A 114
ILE A 193
PHE A 143
 ILE  A 111 ( 0.7A)
ALA  A 138 ( 0.0A)
ILE  A 114 ( 0.7A)
ILE  A 193 ( 0.6A)
PHE  A 143 ( 1.3A)
 1.08A 2w9sC-2rciA:
undetectable		 2w9sC-2rciA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 10 VAL A 121
ILE A 175
ILE A  46
ILE A 118
THR A  93
 VAL  A 121 ( 0.6A)
ILE  A 175 ( 0.6A)
ILE  A  46 ( 0.6A)
ILE  A 118 ( 0.7A)
THR  A  93 ( 0.8A)
 1.25A 3hbbD-2rciA:
undetectable		 3hbbD-2rciA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 10 ALA A 211
VAL A 107
MET A 110
ILE A 205
ILE A 193
 ALA  A 211 ( 0.0A)
VAL  A 107 ( 0.6A)
MET  A 110 ( 0.0A)
ILE  A 205 ( 0.7A)
ILE  A 193 ( 0.6A)
 1.25A 3retA-2rciA:
undetectable
3retB-2rciA:
undetectable		 3retA-2rciA:
18.27
3retB-2rciA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 12 GLY A  94
ALA A 185
VAL A 223
ALA A 219
VAL A 121
 GLY  A  94 ( 0.0A)
ALA  A 185 ( 0.0A)
VAL  A 223 ( 0.6A)
ALA  A 219 ( 0.0A)
VAL  A 121 ( 0.6A)
 0.94A 4df3A-2rciA:
undetectable		 4df3A-2rciA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 12 GLY A  94
ALA A 185
VAL A 223
ALA A 219
VAL A 121
 GLY  A  94 ( 0.0A)
ALA  A 185 ( 0.0A)
VAL  A 223 ( 0.6A)
ALA  A 219 ( 0.0A)
VAL  A 121 ( 0.6A)
 0.96A 4df3B-2rciA:
undetectable		 4df3B-2rciA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 12 ILE A 186
ALA A  57
THR A 180
ILE A 126
LEU A 122
 ILE  A 186 ( 0.7A)
ALA  A  57 ( 0.0A)
THR  A 180 ( 0.8A)
ILE  A 126 ( 0.6A)
LEU  A 122 ( 0.6A)
 1.11A 4kebB-2rciA:
undetectable		 4kebB-2rciA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 12 ILE A  83
PRO A 188
LEU A 220
PHE A  64
GLY A  66
 ILE  A  83 ( 0.7A)
PRO  A 188 ( 1.1A)
LEU  A 220 ( 0.6A)
PHE  A  64 ( 1.3A)
GLY  A  66 ( 0.0A)
 0.91A 5il1A-2rciA:
undetectable		 5il1A-2rciA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 12 ILE A  83
PRO A 188
LEU A 220
PHE A  64
GLY A  66
 ILE  A  83 ( 0.7A)
PRO  A 188 ( 1.1A)
LEU  A 220 ( 0.6A)
PHE  A  64 ( 1.3A)
GLY  A  66 ( 0.0A)
 0.90A 5k7uA-2rciA:
undetectable		 5k7uA-2rciA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 12 ILE A  83
PRO A 188
LEU A 220
PHE A  64
GLY A  66
 ILE  A  83 ( 0.7A)
PRO  A 188 ( 1.1A)
LEU  A 220 ( 0.6A)
PHE  A  64 ( 1.3A)
GLY  A  66 ( 0.0A)
 0.92A 5l6eA-2rciA:
undetectable		 5l6eA-2rciA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		6 / 12 ILE A 205
VAL A 195
ILE A 189
PHE A 143
ILE A 101
ILE A 139
 ILE  A 205 ( 0.7A)
VAL  A 195 ( 0.5A)
ILE  A 189 ( 0.7A)
PHE  A 143 ( 1.3A)
ILE  A 101 ( 0.7A)
ILE  A 139 ( 0.7A)
 1.49A 5mueA-2rciA:
undetectable		 5mueA-2rciA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		6 / 12 ILE A 205
VAL A 195
ILE A 189
PHE A 143
VAL A 100
ILE A 139
 ILE  A 205 ( 0.7A)
VAL  A 195 ( 0.5A)
ILE  A 189 ( 0.7A)
PHE  A 143 ( 1.3A)
VAL  A 100 ( 0.6A)
ILE  A 139 ( 0.7A)
 1.47A 5mueA-2rciA:
undetectable		 5mueA-2rciA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		4 / 6 TYR A  48
ASP A 179
VAL A 125
GLU A 178
 TYR  A  48 ( 1.3A)
ASP  A 179 ( 0.6A)
VAL  A 125 ( 0.5A)
GLU  A 178 ( 0.5A)
 1.25A 6djzB-2rciA:
undetectable		 6djzB-2rciA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN
(Bacillus
thuringiensis) 		5 / 11 ILE A 186
ALA A  90
GLY A  86
PHE A  64
ALA A  80
 ILE  A 186 ( 0.7A)
ALA  A  90 ( 0.0A)
GLY  A  86 ( 0.0A)
PHE  A  64 ( 1.3A)
ALA  A  80 ( 0.0A)
 1.03A 6ieyA-2rciA:
undetectable
6ieyB-2rciA:
undetectable		 6ieyA-2rciA:
19.93
6ieyB-2rciA:
19.93