SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rck'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 2rck JUVENILE HORMONE
BINDING PROTEIN
(Galleria
mellonella) 		5 / 12 THR A 158
VAL A  93
ALA A 122
VAL A 201
ILE A 197
 None
 1.13A 3czhA-2rckA:
undetectable		 3czhA-2rckA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 2rck JUVENILE HORMONE
BINDING PROTEIN
(Galleria
mellonella) 		5 / 12 VAL A 201
ILE A 153
ALA A 120
THR A 158
ILE A 118
 None
 0.99A 3ddyA-2rckA:
undetectable		 3ddyA-2rckA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 2rck JUVENILE HORMONE
BINDING PROTEIN
(Galleria
mellonella) 		5 / 12 THR A 158
VAL A  93
ALA A 122
VAL A 201
ILE A 197
 None
 1.14A 3dl9A-2rckA:
undetectable		 3dl9A-2rckA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2rck JUVENILE HORMONE
BINDING PROTEIN
(Galleria
mellonella) 		4 / 7 LEU A  26
GLN A  73
PHE A  70
VAL A  67
 None
 1.16A 3jwqC-2rckA:
undetectable		 3jwqC-2rckA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2rck JUVENILE HORMONE
BINDING PROTEIN
(Galleria
mellonella) 		3 / 3 GLY A 125
GLU A 147
THR A 148
 None
 0.59A 4kouA-2rckA:
undetectable		 4kouA-2rckA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2rck JUVENILE HORMONE
BINDING PROTEIN
(Galleria
mellonella) 		4 / 6 PHE A  78
VAL A  87
TYR A 128
ILE A 209
 None
 1.15A 5iwuA-2rckA:
2.0		 5iwuA-2rckA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2rck JUVENILE HORMONE
BINDING PROTEIN
(Galleria
mellonella) 		5 / 12 LEU A  65
ILE A  46
ASP A  42
ILE A 118
ILE A 197
 None
 0.94A 6emuA-2rckA:
undetectable		 6emuA-2rckA:
23.63