SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 2rcy PYRROLINE
CARBOXYLATE
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 GLU A   3
ILE A  29
LEU A   7
ILE A 144
THR A 136
 None
 1.15A 1d1gA-2rcyA:
undetectable		 1d1gA-2rcyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2rcy PYRROLINE
CARBOXYLATE
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 LEU A  19
VAL A 110
ILE A  61
PHE A 145
 None
 0.93A 2weyB-2rcyA:
undetectable		 2weyB-2rcyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2rcy PYRROLINE
CARBOXYLATE
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 ILE A 165
GLY A 169
ALA A 171
ALA A 249
VAL A 250
 None
 1.01A 3jb2A-2rcyA:
undetectable		 3jb2A-2rcyA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)		 2rcy PYRROLINE
CARBOXYLATE
REDUCTASE
(Plasmodium
falciparum) 		5 / 10 PRO A 170
SER A 166
GLY A 167
PRO A 117
LEU A  19
 None
None
NAP  A 264 ( 4.8A)
None
None
 1.39A 3lsfB-2rcyA:
undetectable
3lsfE-2rcyA:
undetectable		 3lsfB-2rcyA:
24.57
3lsfE-2rcyA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)		 2rcy PYRROLINE
CARBOXYLATE
REDUCTASE
(Plasmodium
falciparum) 		5 / 10 PRO A 170
SER A 166
GLY A 167
PRO A 117
SER A 124
 None
None
NAP  A 264 ( 4.8A)
None
None
 1.26A 3lsfB-2rcyA:
undetectable
3lsfE-2rcyA:
undetectable		 3lsfB-2rcyA:
24.57
3lsfE-2rcyA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2rcy PYRROLINE
CARBOXYLATE
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 PRO A 170
SER A 166
GLY A 167
PRO A 117
 None
None
NAP  A 264 ( 4.8A)
None
 0.83A 3lslA-2rcyA:
undetectable
3lslD-2rcyA:
undetectable		 3lslA-2rcyA:
24.57
3lslD-2rcyA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2rcy PYRROLINE
CARBOXYLATE
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 PRO A 117
PRO A 170
SER A 166
GLY A 167
 None
None
None
NAP  A 264 ( 4.8A)
 0.90A 3lslA-2rcyA:
undetectable
3lslD-2rcyA:
undetectable		 3lslA-2rcyA:
24.57
3lslD-2rcyA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2rcy PYRROLINE
CARBOXYLATE
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 ILE A  29
GLY A   8
ILE A  23
ASP A  60
LEU A  87
 None
 1.05A 3uj6A-2rcyA:
4.6		 3uj6A-2rcyA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2rcy PYRROLINE
CARBOXYLATE
REDUCTASE
(Plasmodium
falciparum) 		3 / 3 ASN A 142
LEU A  86
PHE A 125
 None
 0.79A 4dajB-2rcyA:
undetectable		 4dajB-2rcyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2rcy PYRROLINE
CARBOXYLATE
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 PHE A 145
SER A 147
ALA A  20
LEU A  19
 None
 1.03A 4rkuA-2rcyA:
undetectable
4rkuJ-2rcyA:
undetectable		 4rkuA-2rcyA:
16.29
4rkuJ-2rcyA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2rcy PYRROLINE
CARBOXYLATE
REDUCTASE
(Plasmodium
falciparum) 		4 / 7 PHE A 145
SER A 147
ALA A  20
LEU A  19
 None
 1.06A 4xk8A-2rcyA:
1.0		 4xk8A-2rcyA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 2rcy PYRROLINE
CARBOXYLATE
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 LEU A  94
ASP A  69
ALA A  71
VAL A  74
 None
None
None
NAP  A 264 (-4.9A)
 0.90A 4zbqA-2rcyA:
3.0		 4zbqA-2rcyA:
17.16