SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 8 PRO A 177
LEU A 134
GLY A 136
LEU A 167
 None
 0.69A 1ya4A-2rd5A:
undetectable		 1ya4A-2rd5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 7 PRO A 177
LEU A 134
GLY A 136
LEU A 167
 None
 0.61A 1ya4B-2rd5A:
undetectable		 1ya4B-2rd5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ILE A 124
VAL A 178
TYR A  42
VAL A  57
LEU A  72
 None
 1.12A 1z9hD-2rd5A:
undetectable		 1z9hD-2rd5A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 12 GLY A  75
GLY A  43
ASN A 117
ALA A 180
ASP A  79
 NLG  A2001 (-3.2A)
None
None
None
None
 1.27A 2vdvE-2rd5A:
3.3		 2vdvE-2rd5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 11 GLY A  75
GLY A  43
ASN A 117
ALA A 180
ASP A  79
 NLG  A2001 (-3.2A)
None
None
None
None
 1.27A 2vdvF-2rd5A:
3.3		 2vdvF-2rd5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ASN A  81
ALA A  91
ARG A  98
 None
None
NLG  A2001 (-4.0A)
 0.87A 3tj7C-2rd5A:
undetectable
3tj7D-2rd5A:
undetectable		 3tj7C-2rd5A:
23.47
3tj7D-2rd5A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 9 PHE A 155
SER A 187
GLY A 188
TYR A 191
ASP A 185
 None
 1.23A 3ztvA-2rd5A:
undetectable		 3ztvA-2rd5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		6 / 12 LEU A 263
ILE A 234
ILE A 231
GLY A 292
ILE A 273
ILE A 295
 None
None
None
ARG  A1000 (-4.4A)
None
None
 1.46A 4q1xB-2rd5A:
undetectable		 4q1xB-2rd5A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 8 LEU A  60
LEU A 281
LEU A 214
ALA A  46
LEU A  72
 None
 1.11A 4z90A-2rd5A:
undetectable
4z90B-2rd5A:
undetectable
4z90C-2rd5A:
undetectable
4z90D-2rd5A:
undetectable
4z90E-2rd5A:
undetectable		 4z90A-2rd5A:
23.46
4z90B-2rd5A:
23.46
4z90C-2rd5A:
23.46
4z90D-2rd5A:
23.46
4z90E-2rd5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 8 LEU A  72
LEU A  60
LEU A 281
LEU A 214
ALA A  46
 None
 1.12A 4z90A-2rd5A:
undetectable
4z90B-2rd5A:
undetectable
4z90C-2rd5A:
undetectable
4z90D-2rd5A:
undetectable
4z90E-2rd5A:
undetectable		 4z90A-2rd5A:
23.46
4z90B-2rd5A:
23.46
4z90C-2rd5A:
23.46
4z90D-2rd5A:
23.46
4z90E-2rd5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 8 LEU A 214
ALA A  46
LEU A  72
LEU A  60
LEU A 281
 None
 1.17A 4z90A-2rd5A:
undetectable
4z90B-2rd5A:
undetectable
4z90C-2rd5A:
undetectable
4z90D-2rd5A:
undetectable
4z90E-2rd5A:
undetectable		 4z90A-2rd5A:
23.46
4z90B-2rd5A:
23.46
4z90C-2rd5A:
23.46
4z90D-2rd5A:
23.46
4z90E-2rd5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		4 / 7 ASN A 192
VAL A 182
SER A 181
ALA A 180
 NLG  A2001 (-2.8A)
None
NLG  A2001 ( 4.2A)
None
 0.81A 5fpdB-2rd5A:
undetectable		 5fpdB-2rd5A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 9 LEU A 170
LEU A 141
PRO A 177
ILE A 179
LEU A 142
 None
 1.42A 5g48B-2rd5A:
undetectable		 5g48B-2rd5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN
(Arabidopsis
thaliana) 		5 / 10 LEU A 263
ILE A 231
GLY A 292
ILE A 273
ILE A 295
 None
None
ARG  A1000 (-4.4A)
None
None
 1.05A 5kr1A-2rd5A:
undetectable		 5kr1A-2rd5A:
18.90