SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rdg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2rdg SUPERANTIGEN-LIKE
PROTEIN 11
(Staphylococcus
aureus) 		3 / 3 ASP A  79
ASN A  80
THR A  45
 None
 0.74A 2pymB-2rdgA:
undetectable		 2pymB-2rdgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 2rdg SUPERANTIGEN-LIKE
PROTEIN 11
(Staphylococcus
aureus) 		4 / 9 ILE A  57
PHE A  38
VAL A  36
GLU A  32
 None
 0.79A 2vufA-2rdgA:
undetectable		 2vufA-2rdgA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2rdg SUPERANTIGEN-LIKE
PROTEIN 11
(Staphylococcus
aureus) 		4 / 5 VAL A  70
GLU A 127
LYS A 136
PHE A 135
 None
 1.41A 3rv5C-2rdgA:
undetectable
3rv5D-2rdgA:
undetectable		 3rv5C-2rdgA:
17.86
3rv5D-2rdgA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2rdg SUPERANTIGEN-LIKE
PROTEIN 11
(Staphylococcus
aureus) 		3 / 3 ASP A  59
GLU A  32
GLY A  33
 None
 0.58A 3w9tA-2rdgA:
undetectable		 3w9tA-2rdgA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2rdg SUPERANTIGEN-LIKE
PROTEIN 11
(Staphylococcus
aureus) 		5 / 12 ILE A 189
LEU A 130
ILE A 157
ARG A 138
ILE A 192
 None
 1.09A 4x5jA-2rdgA:
undetectable		 4x5jA-2rdgA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2rdg SUPERANTIGEN-LIKE
PROTEIN 11
(Staphylococcus
aureus) 		4 / 7 THR A 119
LEU A 103
THR A 117
LEU A 141
 None
 0.82A 4z91F-2rdgA:
undetectable
4z91G-2rdgA:
undetectable
4z91H-2rdgA:
undetectable
4z91I-2rdgA:
undetectable
4z91J-2rdgA:
undetectable		 4z91F-2rdgA:
19.45
4z91G-2rdgA:
19.45
4z91H-2rdgA:
19.45
4z91I-2rdgA:
19.45
4z91J-2rdgA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2rdg SUPERANTIGEN-LIKE
PROTEIN 11
(Staphylococcus
aureus) 		4 / 5 HIS A 140
HIS A 145
VAL A 194
THR A 117
 None
 1.34A 5ohhA-2rdgA:
undetectable		 5ohhA-2rdgA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 2rdg SUPERANTIGEN-LIKE
PROTEIN 11
(Staphylococcus
aureus) 		3 / 3 LEU A 141
LEU A 171
ARG A 138
 None
 0.58A 6fgcA-2rdgA:
undetectable		 6fgcA-2rdgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2rdg SUPERANTIGEN-LIKE
PROTEIN 11
(Staphylococcus
aureus) 		3 / 3 LEU A 141
LEU A 171
ARG A 138
 None
 0.58A 6fgdA-2rdgA:
undetectable		 6fgdA-2rdgA:
18.81