SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rdl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		4 / 8 PHE A 228
THR A 229
ASP A 102
HIS A  57
 None
 0.77A 1ei6C-2rdlA:
undetectable		 1ei6C-2rdlA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		4 / 8 PHE A 228
THR A 229
ASP A 102
HIS A  57
 None
 0.87A 1ei6D-2rdlA:
undetectable		 1ei6D-2rdlA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		5 / 11 ILE A 130
ARG A 134
LEU A 181
PHE A 228
ARG A 137
 None
 1.26A 2bxmA-2rdlA:
undetectable		 2bxmA-2rdlA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		3 / 3 LEU A  46
ARG A  49
ILE A  47
 None
 0.58A 2xn5B-2rdlA:
undetectable		 2xn5B-2rdlA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		4 / 7 MET A  53
PHE A  45
ILE A 208
ASN A 128
 None
 1.15A 2zseA-2rdlA:
undetectable		 2zseA-2rdlA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		6 / 12 GLY A 197
ASN A 189
THR A 229
GLY A 196
SER A 195
GLY A 193
 None
 1.49A 3hlwA-2rdlA:
undetectable		 3hlwA-2rdlA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		6 / 12 GLY A 197
ASN A 189
THR A 229
GLY A 196
SER A 195
GLY A 193
 None
 1.49A 3hlwB-2rdlA:
undetectable		 3hlwB-2rdlA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		4 / 6 LEU A 181
PRO A 165
ARG A 230
HIS A 233
 None
 1.43A 3ltwA-2rdlA:
undetectable		 3ltwA-2rdlA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		5 / 12 GLY A 184
VAL A 190
ASN A 189
THR A 229
LEU A 181
 None
 1.23A 3mteA-2rdlA:
undetectable		 3mteA-2rdlA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		4 / 7 MET A  30
LEU A 155
LEU A 200
PHE A  45
 None
None
SO4  A 247 (-4.0A)
None
 1.20A 3nk2X-2rdlA:
undetectable		 3nk2X-2rdlA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		5 / 12 LYS A  16
GLY A 197
ILE A 212
ALA A  55
ASP A 194
 None
 0.95A 3nvkI-2rdlA:
undetectable		 3nvkI-2rdlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		3 / 3 GLY A  44
SER A  43
TRP A 141
 None
 0.83A 4e7cD-2rdlA:
undetectable		 4e7cD-2rdlA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		4 / 5 SER A 152
GLY A 142
VAL A 139
ASP A 194
 None
 1.10A 4eohA-2rdlA:
undetectable		 4eohA-2rdlA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		6 / 12 GLY A 197
ASN A 189
THR A 229
GLY A 196
SER A 195
GLY A 193
 None
 1.46A 4pm5A-2rdlA:
undetectable		 4pm5A-2rdlA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		4 / 7 ILE A 231
ARG A  48
THR A 120
LEU A 121
 None
 0.94A 5b1aA-2rdlA:
undetectable
5b1aJ-2rdlA:
undetectable		 5b1aA-2rdlA:
17.87
5b1aJ-2rdlA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		4 / 7 ILE A 231
ARG A  48
THR A 120
LEU A 121
 None
 0.94A 5b3sA-2rdlA:
undetectable
5b3sJ-2rdlA:
undetectable		 5b3sA-2rdlA:
17.87
5b3sJ-2rdlA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		4 / 7 ILE A 231
ARG A  48
THR A 120
LEU A 121
 None
 0.90A 5xdqA-2rdlA:
undetectable
5xdqJ-2rdlA:
undetectable		 5xdqA-2rdlA:
17.87
5xdqJ-2rdlA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		4 / 7 ILE A 231
ARG A  48
THR A 120
LEU A 121
 None
 0.96A 5zcqA-2rdlA:
undetectable
5zcqJ-2rdlA:
undetectable		 5zcqA-2rdlA:
17.87
5zcqJ-2rdlA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		4 / 7 ILE A 231
GLN A 210
ILE A  47
THR A 120
 None
 0.93A 6cduF-2rdlA:
undetectable
6cduG-2rdlA:
undetectable		 6cduF-2rdlA:
19.21
6cduG-2rdlA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 2rdl CHYMASE 2
(Mesocricetus
auratus) 		4 / 5 GLY A 211
LEU A 181
SER A 129
GLN A 210
 None
 1.32A 6ji6A-2rdlA:
undetectable		 6ji6A-2rdlA:
21.31