SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rdp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2rdp PUTATIVE
TRANSCRIPTIONAL
REGULATOR MARR
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A  73
LEU A  82
GLY A 103
ILE A 107
 None
 0.82A 1mt1G-2rdpA:
undetectable
1mt1J-2rdpA:
undetectable		 1mt1G-2rdpA:
22.95
1mt1J-2rdpA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2rdp PUTATIVE
TRANSCRIPTIONAL
REGULATOR MARR
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 107
LEU A  73
LEU A  82
GLY A 103
 None
 0.82A 1mt1H-2rdpA:
undetectable
1mt1K-2rdpA:
undetectable		 1mt1H-2rdpA:
21.79
1mt1K-2rdpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2rdp PUTATIVE
TRANSCRIPTIONAL
REGULATOR MARR
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A  73
LEU A  82
GLY A 103
ILE A 107
 None
 0.87A 1n13A-2rdpA:
undetectable
1n13F-2rdpA:
undetectable		 1n13A-2rdpA:
22.95
1n13F-2rdpA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2rdp PUTATIVE
TRANSCRIPTIONAL
REGULATOR MARR
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 107
LEU A  73
LEU A  82
GLY A 103
 None
 0.85A 2qqcH-2rdpA:
undetectable
2qqcK-2rdpA:
undetectable		 2qqcH-2rdpA:
20.78
2qqcK-2rdpA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2rdp PUTATIVE
TRANSCRIPTIONAL
REGULATOR MARR
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 107
LEU A  73
LEU A  82
GLY A 103
 None
 0.85A 2qqdB-2rdpA:
undetectable
2qqdC-2rdpA:
undetectable		 2qqdB-2rdpA:
21.15
2qqdC-2rdpA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2rdp PUTATIVE
TRANSCRIPTIONAL
REGULATOR MARR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  82
LYS A 102
VAL A 110
PHE A  42
LEU A  45
 None
 1.42A 5cymA-2rdpA:
undetectable		 5cymA-2rdpA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2rdp PUTATIVE
TRANSCRIPTIONAL
REGULATOR MARR
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  82
LYS A 102
VAL A 110
PHE A  42
LEU A  45
 None
 1.44A 5cyqA-2rdpA:
undetectable		 5cyqA-2rdpA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 2rdp PUTATIVE
TRANSCRIPTIONAL
REGULATOR MARR
(Geobacillus
stearothermophil
us) 		4 / 7 VAL A  43
LEU A  65
MET A  77
THR A  70
 None
 1.02A 5e4dA-2rdpA:
undetectable
5e4dB-2rdpA:
undetectable		 5e4dA-2rdpA:
18.91
5e4dB-2rdpA:
18.91