SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 5 THR A 151
ASP A 139
HIS A 137
HIS A 226
 OGA  A 268 (-3.8A)
FE  A   1 ( 2.6A)
FE  A   1 (-3.4A)
FE  A   1 ( 3.4A)
 1.16A 1ei6A-2rdsA:
undetectable		 1ei6A-2rdsA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 218
HIS A 137
ASP A 139
SER A 172
PHE A 220
 None
FE  A   1 (-3.4A)
FE  A   1 ( 2.6A)
None
OGA  A 268 (-4.9A)
 1.46A 1uobA-2rdsA:
9.9		 1uobA-2rdsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 11 HIS A 137
ASP A 139
HIS A 226
ARG A 240
SER A 242
 FE  A   1 (-3.4A)
FE  A   1 ( 2.6A)
FE  A   1 ( 3.4A)
OGA  A 268 (-2.9A)
OGA  A 268 ( 4.5A)
 1.03A 1uofA-2rdsA:
5.7		 1uofA-2rdsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 11 HIS A 137
ASP A 139
THR A 151
HIS A 226
SER A 242
 FE  A   1 (-3.4A)
FE  A   1 ( 2.6A)
OGA  A 268 (-3.8A)
FE  A   1 ( 3.4A)
OGA  A 268 ( 4.5A)
 0.64A 1uofA-2rdsA:
5.7		 1uofA-2rdsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 11 PHE A  73
HIS A 137
ASP A 139
THR A 151
HIS A 226
 None
FE  A   1 (-3.4A)
FE  A   1 ( 2.6A)
OGA  A 268 (-3.8A)
FE  A   1 ( 3.4A)
 0.88A 1uofA-2rdsA:
5.7		 1uofA-2rdsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 4 VAL A  76
LEU A  65
ILE A 157
LEU A 156
 None
 0.93A 2byoA-2rdsA:
undetectable		 2byoA-2rdsA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 8 SER A 163
SER A 233
ASN A 231
GLN A 122
 None
 1.13A 2cmlC-2rdsA:
undetectable		 2cmlC-2rdsA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 6 LEU A  56
LEU A  53
MET A  81
GLU A  78
 None
 1.19A 2kuhA-2rdsA:
undetectable		 2kuhA-2rdsA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 4 ALA A  89
VAL A  85
PHE A  90
THR A 114
 None
 1.34A 2pkkA-2rdsA:
undetectable		 2pkkA-2rdsA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 7 THR A  96
VAL A  99
ILE A 217
ILE A 154
 None
 0.83A 3deuA-2rdsA:
undetectable		 3deuA-2rdsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 7 MET A 241
ARG A  50
GLY A  52
MET A  81
 None
 1.07A 3hcnA-2rdsA:
undetectable		 3hcnA-2rdsA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 5 LEU A 218
TYR A   8
ALA A 167
ILE A 229
 None
 1.06A 4y03B-2rdsA:
undetectable		 4y03B-2rdsA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 7 GLU A  51
ARG A  50
ASP A  60
ALA A  59
 None
None
MG  A 266 ( 4.0A)
None
 0.87A 4zz8A-2rdsA:
undetectable		 4zz8A-2rdsA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
(Streptomyces
avermitilis) 		4 / 5 ARG A 150
PHE A  32
LEU A 218
LEU A  15
 None
 0.95A 5veuH-2rdsA:
undetectable		 5veuH-2rdsA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 12 GLY A 164
GLY A 165
ASN A 231
SER A 242
TYR A   8
 None
None
None
OGA  A 268 ( 4.5A)
None
 1.24A 5yf0A-2rdsA:
undetectable		 5yf0A-2rdsA:
19.67