SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rdx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 8 THR A 347
PRO A 348
GLY A 349
THR A 353
 GOL  A 380 (-3.5A)
GOL  A 380 (-4.3A)
GOL  A 380 ( 3.9A)
GOL  A 380 (-4.1A)
 0.56A 1h4oB-2rdxA:
2.1		 1h4oB-2rdxA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		5 / 10 ASP A  12
ARG A 328
ALA A 300
PRO A 104
ALA A 103
 None
 1.22A 1mskA-2rdxA:
0.0		 1mskA-2rdxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 5 ARG A 137
LEU A 322
ASP A 321
LEU A 342
 None
 1.07A 1n13B-2rdxA:
undetectable
1n13C-2rdxA:
undetectable		 1n13B-2rdxA:
15.01
1n13C-2rdxA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 7 LEU A 322
ASP A 321
LEU A 342
ARG A 137
 None
 1.06A 1n13I-2rdxA:
undetectable
1n13L-2rdxA:
undetectable		 1n13I-2rdxA:
11.52
1n13L-2rdxA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 8 THR A 347
PRO A 348
GLY A 349
THR A 353
 GOL  A 380 (-3.5A)
GOL  A 380 (-4.3A)
GOL  A 380 ( 3.9A)
GOL  A 380 (-4.1A)
 0.62A 1oc3A-2rdxA:
2.2		 1oc3A-2rdxA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 5 TYR A 159
MET A 135
THR A 320
LEU A 342
 None
 1.44A 2eimJ-2rdxA:
undetectable		 2eimJ-2rdxA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 5 TYR A 159
MET A 135
THR A 320
LEU A 342
 None
 1.39A 2eimW-2rdxA:
undetectable		 2eimW-2rdxA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		5 / 12 LEU A 350
VAL A 121
LEU A 125
ILE A 266
ALA A 103
 None
 0.89A 2gj5A-2rdxA:
undetectable		 2gj5A-2rdxA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		3 / 3 ASP A 280
ARG A 277
ARG A 276
 None
 0.95A 2j9dA-2rdxA:
undetectable
2j9dC-2rdxA:
undetectable		 2j9dA-2rdxA:
13.77
2j9dC-2rdxA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 7 ARG A 137
LEU A 322
ASP A 321
LEU A 342
 None
 1.06A 2qqcB-2rdxA:
undetectable
2qqcC-2rdxA:
undetectable		 2qqcB-2rdxA:
15.18
2qqcC-2rdxA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 7 LEU A 322
ASP A 321
LEU A 342
ARG A 137
 None
 1.07A 2qqcI-2rdxA:
undetectable
2qqcL-2rdxA:
undetectable		 2qqcI-2rdxA:
11.15
2qqcL-2rdxA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 5 TYR A 159
MET A 135
THR A 320
LEU A 342
 None
 1.45A 3ag1J-2rdxA:
undetectable		 3ag1J-2rdxA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 5 TYR A 159
MET A 135
THR A 320
LEU A 342
 None
 1.42A 3ag2J-2rdxA:
undetectable		 3ag2J-2rdxA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 5 TYR A 159
MET A 135
THR A 320
LEU A 342
 None
 1.42A 3ag4J-2rdxA:
undetectable		 3ag4J-2rdxA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 6 LEU A 322
ASN A 326
SER A 294
PHE A  50
 None
 1.46A 3i9jB-2rdxA:
undetectable		 3i9jB-2rdxA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 6 ILE A 266
ASP A 355
GLY A 297
VAL A  36
 None
 0.90A 3n3iA-2rdxA:
undetectable		 3n3iA-2rdxA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		5 / 12 TYR A 100
GLY A 270
SER A 267
ALA A  72
HIS A  98
 None
 1.22A 3ou7C-2rdxA:
undetectable		 3ou7C-2rdxA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		5 / 12 VAL A 289
LEU A 272
VAL A 304
ALA A 308
SER A 310
 None
 1.05A 3pghA-2rdxA:
undetectable		 3pghA-2rdxA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		5 / 12 VAL A 289
LEU A 272
VAL A 304
ALA A 308
SER A 310
 None
 1.07A 3rr3C-2rdxA:
undetectable		 3rr3C-2rdxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		5 / 12 VAL A 289
LEU A 272
VAL A 304
ALA A 308
SER A 310
 None
 1.07A 3rr3D-2rdxA:
undetectable		 3rr3D-2rdxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		5 / 11 ALA A 108
VAL A 121
GLY A 114
ALA A 116
LEU A 272
 None
 1.04A 3sm2B-2rdxA:
undetectable		 3sm2B-2rdxA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		5 / 10 ALA A 203
ASP A 201
ILE A 177
ALA A 234
VAL A 230
 None
 1.00A 3t3cB-2rdxA:
undetectable		 3t3cB-2rdxA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 8 ARG A 148
LEU A 151
ARG A 155
GLU A 185
 None
 1.35A 3zmdA-2rdxA:
undetectable
3zmdB-2rdxA:
undetectable		 3zmdA-2rdxA:
18.16
3zmdB-2rdxA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 7 PRO A  52
GLY A  64
VAL A  65
SER A  34
 None
 0.98A 4a3uB-2rdxA:
6.4		 4a3uB-2rdxA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		5 / 11 GLY A 331
ALA A 300
GLY A 297
VAL A 352
VAL A  35
 None
 1.22A 4c5lA-2rdxA:
2.2		 4c5lA-2rdxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 7 LYS A 265
ASP A 241
TYR A  57
TYR A  20
 MG  A 378 ( 4.2A)
MG  A 378 (-3.1A)
None
None
 1.37A 5a06E-2rdxA:
undetectable		 5a06E-2rdxA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 7 LYS A 265
ASP A 241
TYR A  57
TYR A  20
 MG  A 378 ( 4.2A)
MG  A 378 (-3.1A)
None
None
 1.38A 5a06F-2rdxA:
2.1		 5a06F-2rdxA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 5 TYR A 159
MET A 135
THR A 320
LEU A 342
 None
 1.38A 5x19J-2rdxA:
undetectable		 5x19J-2rdxA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 5 TYR A 159
MET A 135
THR A 320
LEU A 342
 None
 1.47A 5x1bJ-2rdxA:
undetectable		 5x1bJ-2rdxA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 5 TYR A 159
MET A 135
THR A 320
LEU A 342
 None
 1.45A 5x1bW-2rdxA:
undetectable		 5x1bW-2rdxA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 5 TYR A 159
MET A 135
THR A 320
LEU A 342
 None
 1.43A 5z86J-2rdxA:
undetectable		 5z86J-2rdxA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		4 / 6 GLY A 331
GLY A 334
PRO A 335
GLY A 351
 None
None
None
GOL  A 380 (-3.7A)
 0.72A 6ag0C-2rdxA:
6.9		 6ag0C-2rdxA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE
(Roseovarius
nubinhibens) 		5 / 11 ASP A  12
ARG A 328
ALA A 300
PRO A 104
ALA A 103
 None
 1.15A 6bm5A-2rdxA:
undetectable		 6bm5A-2rdxA:
22.86