SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rdy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 6 HIS A 421
ALA A 409
GLY A 414
TYR A 413
 None
 1.11A 1c8lA-2rdyA:
2.4		 1c8lA-2rdyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 8 ASP A 525
TRP A 488
TYR A 413
THR A 503
 None
 1.49A 1ceaA-2rdyA:
undetectable
1ceaB-2rdyA:
undetectable		 1ceaA-2rdyA:
6.97
1ceaB-2rdyA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 TRP A 732
ARG A 759
THR A 733
 None
 0.95A 1df7A-2rdyA:
undetectable		 1df7A-2rdyA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 8 ALA A 482
LEU A 489
LEU A 486
LEU A 553
ALA A 556
 None
 1.02A 1e7cA-2rdyA:
2.0		 1e7cA-2rdyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 12 PHE A 704
VAL A 728
VAL A 767
SER A 778
LEU A 702
 None
 1.19A 1fm4A-2rdyA:
undetectable		 1fm4A-2rdyA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 6 HIS A 421
ALA A 409
GLY A 414
TYR A 413
 None
 1.13A 1gfzA-2rdyA:
undetectable		 1gfzA-2rdyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 4 LEU A  93
PRO A  94
LEU A 169
ARG A 170
 None
 1.36A 1hrkB-2rdyA:
undetectable		 1hrkB-2rdyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 GLU A 506
ASN A 372
TRP A 626
 None
 1.26A 1r15C-2rdyA:
undetectable		 1r15C-2rdyA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 GLU A 506
ASN A 372
TRP A 626
 None
 1.25A 1r15D-2rdyA:
undetectable		 1r15D-2rdyA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 GLU A 506
ASN A 372
TRP A 626
 None
 1.25A 1r15E-2rdyA:
undetectable		 1r15E-2rdyA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 GLU A 506
ASN A 372
TRP A 626
 None
 1.22A 1r15F-2rdyA:
undetectable		 1r15F-2rdyA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 8 PHE A 484
PHE A 533
LEU A 497
SER A 502
 None
 0.82A 1wrlC-2rdyA:
undetectable
1wrlD-2rdyA:
undetectable		 1wrlC-2rdyA:
8.23
1wrlD-2rdyA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 PHE A 484
PHE A 533
LEU A 497
SER A 502
 None
 0.99A 1wrlE-2rdyA:
undetectable
1wrlF-2rdyA:
undetectable		 1wrlE-2rdyA:
8.23
1wrlF-2rdyA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 12 LEU A 730
LEU A 737
CYH A 644
ALA A 707
ALA A 636
 None
 0.96A 2bm9A-2rdyA:
undetectable		 2bm9A-2rdyA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 12 LEU A 730
LEU A 737
CYH A 644
ALA A 707
ALA A 636
 None
 1.18A 2bm9D-2rdyA:
undetectable		 2bm9D-2rdyA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 10 ALA A 482
LEU A 486
LEU A 553
ALA A 556
LYS A 557
 None
 0.94A 2bxgB-2rdyA:
undetectable		 2bxgB-2rdyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 4 LEU A  93
PRO A  94
LEU A 169
ARG A 170
 None
 1.40A 2hrcB-2rdyA:
undetectable		 2hrcB-2rdyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 4 LEU A  93
PRO A  94
LEU A 169
ARG A 170
 None
 1.32A 2pnjB-2rdyA:
undetectable		 2pnjB-2rdyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 HIS A 456
GLU A 383
HIS A 460
 None
 0.89A 3ba0A-2rdyA:
undetectable		 3ba0A-2rdyA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 8 TYR A  88
ASN A 423
PRO A 505
TRP A 446
 None
 1.21A 3bjwD-2rdyA:
undetectable		 3bjwD-2rdyA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 GLY A 157
GLY A 225
GLY A 238
 None
 0.37A 3bogC-2rdyA:
undetectable		 3bogC-2rdyA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 8 HIS A 456
ILE A 373
TRP A 452
TRP A 630
 None
 1.17A 3ccfB-2rdyA:
undetectable		 3ccfB-2rdyA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 LEU A  98
ALA A 163
LEU A 165
VAL A 236
 None
 0.87A 3d2tA-2rdyA:
undetectable		 3d2tA-2rdyA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 6 HIS A 421
ALA A 409
GLY A 414
TYR A 413
 None
 1.15A 3dd1A-2rdyA:
2.4		 3dd1A-2rdyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 ARG A 337
GLU A 383
ASP A 466
 None
 0.94A 3g2oA-2rdyA:
undetectable		 3g2oA-2rdyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 12 LEU A 648
GLY A 623
ILE A 655
LEU A 652
ILE A 318
 None
 0.87A 3ijdA-2rdyA:
undetectable		 3ijdA-2rdyA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 8 VAL A 588
TRP A 630
TRP A 635
PHE A 638
 None
 1.13A 3nlqA-2rdyA:
undetectable
3nlqB-2rdyA:
undetectable		 3nlqA-2rdyA:
19.75
3nlqB-2rdyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 5 GLY A 665
GLU A 659
GLY A 666
PRO A 676
 None
 1.09A 3onnA-2rdyA:
undetectable		 3onnA-2rdyA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 12 ALA A 674
HIS A 675
GLY A 682
TYR A 335
LEU A 328
 None
 1.30A 3tm4B-2rdyA:
undetectable		 3tm4B-2rdyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 ARG A 723
GLU A 383
THR A 384
 None
 0.81A 3v4tA-2rdyA:
undetectable		 3v4tA-2rdyA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 5 LEU A 328
LEU A 332
LEU A 648
SER A 649
 None
 0.98A 3vhuA-2rdyA:
undetectable		 3vhuA-2rdyA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 5 HIS A 215
SER A 183
SER A 173
VAL A 172
 None
 1.38A 4a99D-2rdyA:
undetectable		 4a99D-2rdyA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_B_QMRB301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 9 TYR A 338
VAL A 140
TYR A 292
VAL A 148
ILE A 122
 None
 1.49A 4aftB-2rdyA:
0.2
4aftC-2rdyA:
0.3		 4aftB-2rdyA:
14.68
4aftC-2rdyA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 8 TYR A 338
TYR A 292
VAL A 148
ILE A 122
 None
 1.07A 4aftD-2rdyA:
undetectable
4aftE-2rdyA:
undetectable		 4aftD-2rdyA:
14.68
4aftE-2rdyA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.14A 4cwxA-2rdyA:
undetectable
4cwxB-2rdyA:
2.3		 4cwxA-2rdyA:
21.53
4cwxB-2rdyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 VAL A 588
TRP A 630
TRP A 635
PHE A 638
 None
 1.15A 4cwyA-2rdyA:
2.1
4cwyB-2rdyA:
2.2		 4cwyA-2rdyA:
21.53
4cwyB-2rdyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.15A 4cwyA-2rdyA:
2.1
4cwyB-2rdyA:
2.2		 4cwyA-2rdyA:
21.53
4cwyB-2rdyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 ARG A  66
TYR A 516
ASN A 576
 None
 0.93A 4ffwB-2rdyA:
undetectable		 4ffwB-2rdyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 GLU A 459
TYR A 461
ARG A 542
GLY A 724
 None
 1.04A 4fgzA-2rdyA:
undetectable		 4fgzA-2rdyA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 8 GLU A 459
TYR A 461
ARG A 542
GLY A 724
 None
 0.96A 4fgzA-2rdyA:
undetectable
4fgzB-2rdyA:
undetectable		 4fgzA-2rdyA:
14.71
4fgzB-2rdyA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 8 MET A 102
LEU A  98
ALA A 163
LEU A 165
 None
 0.79A 4iizB-2rdyA:
undetectable		 4iizB-2rdyA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 8 MET A 102
LEU A  98
ALA A 163
VAL A 236
 None
 0.69A 4iizB-2rdyA:
undetectable		 4iizB-2rdyA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 8 MET A 102
LEU A  98
ALA A 163
LEU A 165
 None
 0.77A 4ik6B-2rdyA:
undetectable		 4ik6B-2rdyA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 8 MET A 102
LEU A  98
ALA A 163
VAL A 236
 None
 0.73A 4ik6B-2rdyA:
undetectable		 4ik6B-2rdyA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 MET A 102
LEU A  98
ALA A 163
VAL A 236
 None
 0.78A 4ik7A-2rdyA:
undetectable		 4ik7A-2rdyA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 9 PHE A 445
HIS A 421
PHE A 484
ILE A 490
 None
 1.21A 4jvlA-2rdyA:
undetectable		 4jvlA-2rdyA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 10 LEU A 234
LEU A 244
ALA A 220
LEU A 159
LEU A 227
 None
 1.21A 4p65A-2rdyA:
undetectable
4p65B-2rdyA:
undetectable
4p65F-2rdyA:
undetectable
4p65H-2rdyA:
undetectable		 4p65A-2rdyA:
7.14
4p65B-2rdyA:
4.65
4p65F-2rdyA:
4.65
4p65H-2rdyA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 ASP A 582
GLN A 507
PRO A 505
ILE A 618
 None
 1.02A 4pcuA-2rdyA:
undetectable		 4pcuA-2rdyA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 12 GLY A 682
VAL A 667
LEU A 332
ASN A 650
ILE A 632
 None
 1.18A 4pd5A-2rdyA:
undetectable		 4pd5A-2rdyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 5 THR A 272
THR A 269
THR A  44
ASN A  22
 None
 1.19A 4pgfB-2rdyA:
undetectable		 4pgfB-2rdyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 12 LEU A 303
LEU A 694
SER A 711
CYH A 644
THR A 687
 None
 1.19A 4q0dC-2rdyA:
undetectable		 4q0dC-2rdyA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 12 LEU A 303
LEU A 694
SER A 711
CYH A 644
THR A 687
 None
 1.20A 4q0dD-2rdyA:
undetectable		 4q0dD-2rdyA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 GLN A 699
HIS A 698
ARG A 637
 None
 0.92A 4qyqA-2rdyA:
undetectable		 4qyqA-2rdyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 GLN A 699
HIS A 698
ARG A 637
 None
 0.93A 4qyqB-2rdyA:
undetectable		 4qyqB-2rdyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 4 GLU A 459
GLY A 597
HIS A 698
ARG A 723
 None
 1.31A 4r82A-2rdyA:
0.0
4r82B-2rdyA:
0.0		 4r82A-2rdyA:
14.20
4r82B-2rdyA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 6 TYR A 379
TYR A 369
LEU A 371
PHE A 397
 None
 1.31A 4twdB-2rdyA:
4.3
4twdC-2rdyA:
4.2		 4twdB-2rdyA:
17.50
4twdC-2rdyA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 ASN A 358
PRO A  94
TRP A  14
PHE A  30
 None
 1.47A 4v32A-2rdyA:
undetectable		 4v32A-2rdyA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 ASN A 358
PRO A  94
TRP A  14
PHE A  30
 None
 1.43A 4v32B-2rdyA:
0.0		 4v32B-2rdyA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 5 LEU A  98
ALA A 163
LEU A 165
VAL A 236
 None
 0.91A 5cr1A-2rdyA:
undetectable		 5cr1A-2rdyA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 8 TYR A 338
PHE A 684
TYR A 335
GLY A 355
 None
 0.76A 5esfA-2rdyA:
undetectable		 5esfA-2rdyA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 12 HIS A 113
LEU A  18
VAL A 285
LYS A   4
ASP A 117
 None
 1.23A 5hg0A-2rdyA:
undetectable		 5hg0A-2rdyA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 12 VAL A 433
PRO A  87
ALA A 431
PHE A 397
ASN A 423
 None
 1.45A 5hgcA-2rdyA:
undetectable		 5hgcA-2rdyA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 VAL A 108
HIS A 113
VAL A 125
 None
 0.72A 5jmnC-2rdyA:
undetectable		 5jmnC-2rdyA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.14A 5uo9A-2rdyA:
undetectable
5uo9B-2rdyA:
0.0		 5uo9A-2rdyA:
20.86
5uo9B-2rdyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.12A 5uo9C-2rdyA:
undetectable
5uo9D-2rdyA:
0.0		 5uo9C-2rdyA:
20.86
5uo9D-2rdyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOC_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 6 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.07A 5uocA-2rdyA:
0.0
5uocB-2rdyA:
0.0		 5uocA-2rdyA:
20.86
5uocB-2rdyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOC_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 5 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.15A 5uocC-2rdyA:
0.0
5uocD-2rdyA:
0.0		 5uocC-2rdyA:
20.86
5uocD-2rdyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 VAL A 588
TRP A 630
TRP A 635
PHE A 638
 None
 1.12A 5vv9A-2rdyA:
undetectable
5vv9B-2rdyA:
undetectable		 5vv9A-2rdyA:
21.53
5vv9B-2rdyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 VAL A 588
TRP A 630
TRP A 635
PHE A 638
 None
 1.12A 5vvaA-2rdyA:
undetectable
5vvaB-2rdyA:
undetectable		 5vvaA-2rdyA:
21.53
5vvaB-2rdyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.11A 5vvdA-2rdyA:
undetectable
5vvdB-2rdyA:
undetectable		 5vvdA-2rdyA:
20.86
5vvdB-2rdyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 12 SER A 367
ASP A 425
ALA A 424
PRO A 350
PHE A 397
 None
 1.21A 5zvgA-2rdyA:
undetectable		 5zvgA-2rdyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 12 SER A 367
ASP A 425
ALA A 424
PRO A 350
PHE A 397
 None
 1.20A 5zvgB-2rdyA:
undetectable		 5zvgB-2rdyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.12A 6av6A-2rdyA:
undetectable
6av6B-2rdyA:
undetectable		 6av6A-2rdyA:
6.76
6av6B-2rdyA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 9 ALA A 686
ALA A 688
THR A 384
LEU A 720
LEU A 694
 None
 1.41A 6ay6A-2rdyA:
undetectable		 6ay6A-2rdyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 ALA A 686
ILE A   5
LEU A 671
ILE A 341
 None
 0.88A 6b5vA-2rdyA:
0.0
6b5vB-2rdyA:
undetectable		 6b5vA-2rdyA:
7.45
6b5vB-2rdyA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 ALA A 686
ILE A   5
LEU A 671
ILE A 341
 None
 0.88A 6b5vB-2rdyA:
undetectable
6b5vD-2rdyA:
0.5		 6b5vB-2rdyA:
7.45
6b5vD-2rdyA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 TRP A 630
TRP A 635
PHE A 638
VAL A 588
 None
 1.13A 6cieA-2rdyA:
0.0
6cieB-2rdyA:
0.0		 6cieA-2rdyA:
6.76
6cieB-2rdyA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		4 / 7 VAL A 588
TRP A 630
TRP A 635
PHE A 638
 None
 1.15A 6cifC-2rdyA:
undetectable
6cifD-2rdyA:
undetectable		 6cifC-2rdyA:
6.76
6cifD-2rdyA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 ARG A 508
PHE A 509
GLY A 515
 None
 0.69A 6fgdA-2rdyA:
undetectable		 6fgdA-2rdyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		3 / 3 TRP A 380
GLU A 459
GLU A 692
 None
 1.02A 6fhwA-2rdyA:
7.3		 6fhwA-2rdyA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 9 ILE A  38
ALA A  27
GLY A  26
LEU A  25
GLY A 121
 None
 1.06A 6nm4B-2rdyA:
undetectable		 6nm4B-2rdyA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2rdy BH0842 PROTEIN
(Bacillus
halodurans) 		5 / 9 ILE A 655
ALA A 674
GLY A 673
GLY A 629
ARG A 664
 None
 1.36A 6nm4B-2rdyA:
undetectable		 6nm4B-2rdyA:
12.96