SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2re1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2DTJ_A_THRA401_0 (ASPARTOKINASE)	2re1	ASPARTOKINASE, ALPHA AND BETA SUBUNITS (Neisseria meningitidis)	4 / 8	ASP A 273 ALA A 278 GLN A 297 THR A 305	None	0.58A	2dtjA-2re1A: 20.9 2dtjB-2re1A: 21.0	2dtjA-2re1A: 48.43 2dtjB-2re1A: 48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2DTJ_A_THRA401_0 (ASPARTOKINASE)	2re1	ASPARTOKINASE, ALPHA AND BETA SUBUNITS (Neisseria meningitidis)	4 / 8	ASP A 273 GLY A 276 ALA A 278 GLN A 297	None	0.51A	2dtjA-2re1A: 20.9 2dtjB-2re1A: 21.0	2dtjA-2re1A: 48.43 2dtjB-2re1A: 48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2DTJ_B_THRB402_0 (ASPARTOKINASE)	2re1	ASPARTOKINASE, ALPHA AND BETA SUBUNITS (Neisseria meningitidis)	5 / 9	ASP A 273 GLY A 276 ALA A 278 GLN A 297 THR A 305	None	0.57A	2dtjA-2re1A: 20.9 2dtjB-2re1A: 21.0	2dtjA-2re1A: 48.43 2dtjB-2re1A: 48.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UXQ_A_0LIA1752_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 4)	2re1	ASPARTOKINASE, ALPHA AND BETA SUBUNITS (Neisseria meningitidis)	4 / 7	VAL A 285 ILE A 295 ALA A 278 ILE A 296	None	0.83A	4uxqA-2re1A: undetectable	4uxqA-2re1A: 20.58

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2DTJ_A_THRA401_0","ASPARTOKINASE","2re1","ASPARTOKINASE, ALPHA AND BETA SUBUNITS","Neisseria meningitidis",4,"ASP A 273;ALA A 278;GLN A 297;THR A 305","None","0.58A","2dtjA-2re1A:20.9;2dtjB-2re1A:21.0","2dtjA-2re1A:48.43;2dtjB-2re1A:48.43"],["2DTJ_A_THRA401_0","ASPARTOKINASE","2re1","ASPARTOKINASE, ALPHA AND BETA SUBUNITS","Neisseria meningitidis",4,"ASP A 273;GLY A 276;ALA A 278;GLN A 297","None","0.51A","2dtjA-2re1A:20.9;2dtjB-2re1A:21.0","2dtjA-2re1A:48.43;2dtjB-2re1A:48.43"],["2DTJ_B_THRB402_0","ASPARTOKINASE","2re1","ASPARTOKINASE, ALPHA AND BETA SUBUNITS","Neisseria meningitidis",5,"ASP A 273;GLY A 276;ALA A 278;GLN A 297;THR A 305","None","0.57A","2dtjA-2re1A:20.9;2dtjB-2re1A:21.0","2dtjA-2re1A:48.43;2dtjB-2re1A:48.43"],["4UXQ_A_0LIA1752_2","FIBROBLAST GROWTH FACTOR RECEPTOR 4","2re1","ASPARTOKINASE, ALPHA AND BETA SUBUNITS","Neisseria meningitidis",4,"VAL A 285;ILE A 295;ALA A 278;ILE A 296","None","0.83A","4uxqA-2re1A:undetectable","4uxqA-2re1A:20.58"]]