SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2reb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2reb REC A
(Escherichia
coli) 		5 / 12 LEU A 263
GLU A 273
LYS A 310
LEU A 107
GLY A  43
 None
 1.21A 1d4fB-2rebA:
undetectable		 1d4fB-2rebA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2reb REC A
(Escherichia
coli) 		5 / 12 LEU A 263
GLU A 273
LYS A 310
LEU A 107
GLY A  43
 None
 1.14A 1d4fD-2rebA:
undetectable		 1d4fD-2rebA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2reb REC A
(Escherichia
coli) 		5 / 12 ILE A  40
LEU A  56
ALA A  82
GLY A  43
SER A  44
 None
 0.92A 2a58A-2rebA:
undetectable
2a58B-2rebA:
undetectable		 2a58A-2rebA:
20.25
2a58B-2rebA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2reb REC A
(Escherichia
coli) 		5 / 12 ILE A  40
LEU A  56
ALA A  82
GLY A  43
SER A  44
 None
 0.91A 2a58B-2rebA:
undetectable
2a58C-2rebA:
2.1		 2a58B-2rebA:
20.25
2a58C-2rebA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2reb REC A
(Escherichia
coli) 		5 / 12 ILE A  40
LEU A  56
ALA A  82
GLY A  43
SER A  44
 None
 0.92A 2a58D-2rebA:
undetectable
2a58E-2rebA:
2.8		 2a58D-2rebA:
20.25
2a58E-2rebA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2reb REC A
(Escherichia
coli) 		5 / 12 PRO A  57
LEU A 188
ASN A 249
ILE A  64
THR A  73
 None
 1.43A 3a51B-2rebA:
undetectable		 3a51B-2rebA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 2reb REC A
(Escherichia
coli) 		5 / 12 GLY A 180
ASP A 139
ILE A 190
LEU A  56
ASN A 186
 None
 1.18A 3eeoA-2rebA:
undetectable		 3eeoA-2rebA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2reb REC A
(Escherichia
coli) 		3 / 3 GLU A 154
LEU A 166
LEU A 126
 None
 0.76A 3ohtB-2rebA:
undetectable		 3ohtB-2rebA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2reb REC A
(Escherichia
coli) 		5 / 10 GLY A  55
LEU A  45
LEU A 328
LEU A  51
ILE A  49
 None
 1.17A 3wdmD-2rebA:
undetectable		 3wdmD-2rebA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 2reb REC A
(Escherichia
coli) 		5 / 10 ILE A  64
ASP A  48
GLY A  43
SER A  44
PHE A 260
 None
 1.13A 4bwlC-2rebA:
undetectable		 4bwlC-2rebA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 2reb REC A
(Escherichia
coli) 		5 / 12 ALA A 258
GLU A 273
GLY A 272
GLN A  78
GLY A 267
 None
 1.28A 4uilH-2rebA:
undetectable
4uilL-2rebA:
undetectable		 4uilH-2rebA:
19.44
4uilL-2rebA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2reb REC A
(Escherichia
coli) 		4 / 7 ASN A 249
PRO A 254
PHE A 255
TYR A  65
 None
 1.46A 4v2yB-2rebA:
undetectable		 4v2yB-2rebA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		 2reb REC A
(Escherichia
coli) 		4 / 7 ASN A 249
PRO A 254
PHE A 255
TYR A  65
 None
 1.39A 4v2yC-2rebA:
0.0		 4v2yC-2rebA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 2reb REC A
(Escherichia
coli) 		4 / 8 ASN A 249
PRO A 254
PHE A 255
TYR A  65
 None
 1.44A 4v2zC-2rebA:
undetectable		 4v2zC-2rebA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2reb REC A
(Escherichia
coli) 		4 / 7 TYR A  65
ILE A 192
GLY A  71
THR A 242
 None
 0.85A 4ze3A-2rebA:
undetectable		 4ze3A-2rebA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2reb REC A
(Escherichia
coli) 		4 / 7 ASN A 249
PRO A 254
PHE A 255
TYR A  65
 None
 1.37A 5amhA-2rebA:
0.0		 5amhA-2rebA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2reb REC A
(Escherichia
coli) 		4 / 8 ASN A 249
PRO A 254
PHE A 255
TYR A  65
 None
 1.49A 5amkA-2rebA:
undetectable		 5amkA-2rebA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2reb REC A
(Escherichia
coli) 		4 / 8 TYR A  65
ILE A 192
GLY A  71
THR A 242
 None
 0.83A 5eseA-2rebA:
undetectable		 5eseA-2rebA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2reb REC A
(Escherichia
coli) 		4 / 8 TYR A  65
ILE A 192
GLY A  71
THR A 242
 None
 0.81A 5esfA-2rebA:
undetectable		 5esfA-2rebA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2reb REC A
(Escherichia
coli) 		4 / 8 TYR A  65
ILE A 192
GLY A  71
THR A 242
 None
 0.83A 5esjA-2rebA:
undetectable		 5esjA-2rebA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2reb REC A
(Escherichia
coli) 		4 / 7 TYR A  65
ILE A 192
GLY A  71
THR A 242
 None
 0.82A 5esmA-2rebA:
undetectable		 5esmA-2rebA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2reb REC A
(Escherichia
coli) 		5 / 12 LEU A 126
PHE A 191
ILE A  93
ALA A  91
GLY A  59
 None
 1.04A 5veuA-2rebA:
undetectable		 5veuA-2rebA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 2reb REC A
(Escherichia
coli) 		4 / 6 GLU A 320
LYS A 322
GLU A 318
ALA A 316
 None
 1.20A 6an0A-2rebA:
3.0		 6an0A-2rebA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 2reb REC A
(Escherichia
coli) 		4 / 5 ILE A  93
SER A 117
ALA A 131
LEU A 178
 None
 1.03A 6dwnA-2rebA:
undetectable		 6dwnA-2rebA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2reb REC A
(Escherichia
coli) 		3 / 3 PHE A 270
ARG A 324
ALA A  82
 None
 0.70A 6ecfB-2rebA:
undetectable		 6ecfB-2rebA:
22.53