SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
None
1.11A 2bm9A-2rekA:
undetectable
2bm9A-2rekA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
None
1.03A 2bm9C-2rekA:
undetectable
2bm9C-2rekA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
None
1.05A 2bm9D-2rekA:
undetectable
2bm9D-2rekA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
None
1.03A 2bm9E-2rekA:
undetectable
2bm9E-2rekA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
None
0.99A 2br4A-2rekA:
undetectable
2br4A-2rekA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
None
1.07A 2br4C-2rekA:
undetectable
2br4C-2rekA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
None
1.03A 2br4D-2rekA:
undetectable
2br4D-2rekA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor)
5 / 12 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
None
1.00A 2br4E-2rekA:
undetectable
2br4E-2rekA:
20.99