SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 2rem DISULFIDE
OXIDOREDUCTASE
(Xylella
fastidiosa) 		4 / 5 PRO A 154
VAL A 152
VAL A 161
ILE A  33
 None
 1.08A 1z2bC-2remA:
undetectable		 1z2bC-2remA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2rem DISULFIDE
OXIDOREDUCTASE
(Xylella
fastidiosa) 		4 / 8 ILE A  99
HIS A 100
PHE A  96
GLY A  35
 None
 0.81A 3b9lA-2remA:
undetectable		 3b9lA-2remA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2rem DISULFIDE
OXIDOREDUCTASE
(Xylella
fastidiosa) 		5 / 12 ALA A  82
PHE A 118
LEU A 115
ILE A  99
SER A 104
 None
 1.08A 3k2hB-2remA:
undetectable		 3k2hB-2remA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2rem DISULFIDE
OXIDOREDUCTASE
(Xylella
fastidiosa) 		5 / 12 VAL A  64
ALA A  66
TRP A  72
PHE A 173
LEU A  48
 None
 1.42A 4kyaB-2remA:
undetectable		 4kyaB-2remA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2rem DISULFIDE
OXIDOREDUCTASE
(Xylella
fastidiosa) 		5 / 12 VAL A  64
ALA A  66
TRP A  72
PHE A 173
LEU A  48
 None
 1.45A 4kyaD-2remA:
undetectable		 4kyaD-2remA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2rem DISULFIDE
OXIDOREDUCTASE
(Xylella
fastidiosa) 		5 / 12 VAL A  64
ALA A  66
TRP A  72
PHE A 173
LEU A  48
 None
 1.45A 4kyaF-2remA:
undetectable		 4kyaF-2remA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2rem DISULFIDE
OXIDOREDUCTASE
(Xylella
fastidiosa) 		5 / 12 VAL A  64
ALA A  66
TRP A  72
PHE A 173
LEU A  48
 None
 1.43A 4kyaH-2remA:
undetectable		 4kyaH-2remA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 2rem DISULFIDE
OXIDOREDUCTASE
(Xylella
fastidiosa) 		3 / 3 GLY A  35
CYH A  41
CYH A  38
 None
 0.88A 5inzB-2remA:
undetectable		 5inzB-2remA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2rem DISULFIDE
OXIDOREDUCTASE
(Xylella
fastidiosa) 		3 / 3 ASP A  73
ASN A 109
GLN A 108
 None
 0.80A 5k7uA-2remA:
undetectable		 5k7uA-2remA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 2rem DISULFIDE
OXIDOREDUCTASE
(Xylella
fastidiosa) 		3 / 3 GLU A  14
ARG A 165
TYR A 166
 None
 0.48A 5trqB-2remA:
undetectable		 5trqB-2remA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2rem DISULFIDE
OXIDOREDUCTASE
(Xylella
fastidiosa) 		4 / 9 HIS A 171
ASP A 175
VAL A 184
ASP A 181
 None
 0.90A 6c2mD-2remA:
undetectable		 6c2mD-2remA:
17.10