SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2reo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		3 / 4 VAL A 146
TRP A 181
TRP A 273
 None
 1.30A 1gmkA-2reoA:
undetectable
1gmkB-2reoA:
undetectable		 1gmkA-2reoA:
3.64
1gmkB-2reoA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		5 / 12 GLY A 178
GLY A 179
GLY A 174
PHE A 157
HIS A 117
 None
 1.21A 1wg8B-2reoA:
undetectable		 1wg8B-2reoA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		6 / 10 PRO A  55
LYS A  56
HIS A 117
PHE A 151
ALA A 155
MET A 257
 None
A3P  A 401 (-2.8A)
None
None
None
None
 0.66A 2d06A-2reoA:
32.0		 2d06A-2reoA:
51.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		6 / 10 PRO A  55
HIS A 117
PHE A 151
ALA A 155
TYR A 249
MET A 257
 None
 0.60A 2d06B-2reoA:
31.8		 2d06B-2reoA:
51.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		5 / 12 ILE A  65
TRP A  61
LEU A 200
VAL A 137
ALA A 138
 None
A3P  A 401 (-3.2A)
None
None
None
 1.19A 4foxD-2reoA:
undetectable		 4foxD-2reoA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		4 / 8 LEU A 113
THR A  53
LEU A  49
VAL A 137
 None
A3P  A 401 ( 4.8A)
None
None
 0.94A 4iizB-2reoA:
undetectable		 4iizB-2reoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		4 / 8 LEU A 113
THR A  53
LEU A  49
VAL A 137
 None
A3P  A 401 ( 4.8A)
None
None
 0.93A 4ik6B-2reoA:
undetectable		 4ik6B-2reoA:
17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		4 / 9 HIS A 117
PHE A 151
ILE A 256
MET A 257
 None
 0.65A 4jvlA-2reoA:
30.8		 4jvlA-2reoA:
51.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		5 / 12 MET A  62
VAL A 137
ILE A 213
LEU A  66
VAL A 135
 None
 1.25A 5im2A-2reoA:
undetectable		 5im2A-2reoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		4 / 8 LEU A 200
VAL A 137
VAL A 135
ILE A  65
 None
 0.65A 5y9mA-2reoA:
undetectable		 5y9mA-2reoA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2reo PUTATIVE
SULFOTRANSFERASE 1C3
(Homo
sapiens) 		4 / 8 LEU A 200
VAL A 137
VAL A 135
ILE A  65
 None
 0.66A 5y9mX-2reoA:
undetectable		 5y9mX-2reoA:
12.15