SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2rex RHO-RELATED
GTP-BINDING PROTEIN
RHO6
(Homo
sapiens) 		4 / 8 CYH B  24
ASP B  93
CYH B 125
GLY B 124
 GNP  B 500 (-3.9A)
None
UNX  B 554 ( 4.2A)
None
 0.98A 1ekjA-2rexB:
undetectable
1ekjB-2rexB:
3.0		 1ekjA-2rexB:
19.74
1ekjB-2rexB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2rex RHO-RELATED
GTP-BINDING PROTEIN
RHO6
(Homo
sapiens) 		4 / 8 ASP B  93
GLY B 124
SER B 168
THR B 171
 None
None
GNP  B 500 (-3.6A)
None
 0.86A 1m4iA-2rexB:
undetectable		 1m4iA-2rexB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2rex RHO-RELATED
GTP-BINDING PROTEIN
RHO6
(Homo
sapiens) 		3 / 3 ALA B  87
VAL B  17
TRP B  66
 None
 0.95A 1tkqA-2rexB:
undetectable		 1tkqA-2rexB:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2rex PLEXIN-B1
(Homo
sapiens) 		4 / 5 VAL A1841
LEU A1836
TYR A1839
ILE A1777
 None
None
None
UNX  A  11 ( 4.8A)
 1.01A 3n8yB-2rexA:
undetectable		 3n8yB-2rexA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2rex RHO-RELATED
GTP-BINDING PROTEIN
RHO6
(Homo
sapiens) 		4 / 7 ILE B 155
LEU B 122
LYS B 106
GLY B  20
 None
 0.77A 4hajA-2rexB:
undetectable		 4hajA-2rexB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2rex RHO-RELATED
GTP-BINDING PROTEIN
RHO6
(Homo
sapiens) 		4 / 8 ILE B 155
LEU B 122
LYS B 106
GLY B  20
 None
 0.84A 4hb6A-2rexB:
undetectable		 4hb6A-2rexB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2rex PLEXIN-B1
(Homo
sapiens) 		4 / 8 LEU A1785
LEU A1788
GLY A1758
LYS A1781
 None
None
None
UNX  A  11 (-3.5A)
 0.94A 6ce2A-2rexA:
undetectable		 6ce2A-2rexA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2rex PLEXIN-B1
RHO-RELATED
GTP-BINDING PROTEIN
RHO6
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A1751
ILE A1777
THR A1823
VAL B  77
LEU A1772
 None
UNX  A  11 ( 4.8A)
None
None
None
 1.33A 6djzB-2rexA:
undetectable		 6djzB-2rexA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 2rex RHO-RELATED
GTP-BINDING PROTEIN
RHO6
(Homo
sapiens) 		4 / 5 ILE B 147
SER B 148
ALA B 156
LEU B 104
 None
None
UNX  B 559 ( 4.1A)
None
 1.02A 6dwnA-2rexB:
undetectable		 6dwnA-2rexB:
14.21