SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2REZ_A_ACTA155_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 2rez MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN
(Streptomyces
glaucescens) 		5 / 5 TRP A  65
ARG A  82
GLY A  86
PRO A  87
PHE A  88
 ACT  A 156 (-4.9A)
IOD  A 157 (-3.6A)
ACT  A 155 (-3.0A)
ACT  A 155 (-3.9A)
ACT  A 155 (-4.8A)
 0.00A 2rezA-2rezA:
30.5		 2rezA-2rezA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2REZ_A_ACTA156_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 2rez MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN
(Streptomyces
glaucescens) 		7 / 7 GLU A  34
THR A  54
TRP A  63
TRP A  65
ARG A  82
MET A 125
LEU A 129
 ACT  A 156 (-4.0A)
ACT  A 156 ( 4.5A)
ACT  A 156 (-3.6A)
ACT  A 156 (-4.9A)
IOD  A 157 (-3.6A)
ACT  A 156 ( 3.9A)
None
 0.04A 2rezA-2rezA:
30.5		 2rezA-2rezA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2rez MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN
(Streptomyces
glaucescens) 		4 / 8 ASN A 136
PHE A  32
TRP A  95
TYR A  97
 None
 1.43A 5amkA-2rezA:
undetectable		 5amkA-2rezA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2rez MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN
(Streptomyces
glaucescens) 		4 / 5 GLN A 110
VAL A 109
TRP A  95
THR A  77
 None
 1.37A 6cduA-2rezA:
undetectable
6cduB-2rezA:
undetectable		 6cduA-2rezA:
19.75
6cduB-2rezA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2rez MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN
(Streptomyces
glaucescens) 		5 / 7 THR A  77
TYR A  97
GLN A 110
VAL A 109
TRP A  95
 None
 1.34A 6cduA-2rezA:
undetectable
6cduE-2rezA:
undetectable		 6cduA-2rezA:
19.75
6cduE-2rezA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2rez MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN
(Streptomyces
glaucescens) 		5 / 8 GLN A 110
VAL A 109
TRP A  95
THR A  77
TYR A  97
 None
 1.41A 6cduD-2rezA:
undetectable
6cduE-2rezA:
undetectable		 6cduD-2rezA:
19.75
6cduE-2rezA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2rez MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN
(Streptomyces
glaucescens) 		5 / 7 GLN A 110
VAL A 109
TRP A  95
THR A  77
TYR A  97
 None
 1.36A 6cduH-2rezA:
undetectable
6cduI-2rezA:
undetectable		 6cduH-2rezA:
19.75
6cduI-2rezA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2rez MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN
(Streptomyces
glaucescens) 		4 / 5 GLN A 110
VAL A 109
TRP A  95
THR A  77
 None
 1.50A 6cduI-2rezA:
undetectable
6cduJ-2rezA:
undetectable		 6cduI-2rezA:
19.75
6cduJ-2rezA:
19.75