SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
(Saccharomyces
cerevisiae) 		4 / 7 LEU B  89
VAL A  70
MET A  71
LEU A 122
 None
 0.82A 1hk3A-2rf4B:
2.6		 1hk3A-2rf4B:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 147
GLY A 146
HIS A 144
ILE A 157
 None
 0.81A 1xf1A-2rf4A:
undetectable		 1xf1A-2rf4A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 147
GLY A 146
HIS A 144
ILE A 157
 None
 0.83A 1xf1B-2rf4A:
undetectable		 1xf1B-2rf4A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
(Saccharomyces
cerevisiae) 		5 / 9 GLY A  79
GLN A 126
VAL A 124
VAL A 243
VAL A 236
 None
 1.45A 3fi0L-2rf4A:
undetectable		 3fi0L-2rf4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 166
VAL A 169
TRP A 217
 None
 1.04A 3zq8C-2rf4A:
undetectable
3zq8D-2rf4A:
undetectable		 3zq8C-2rf4A:
5.69
3zq8D-2rf4A:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 133
PHE A 153
VAL A 245
PRO A 127
HIS B  30
 None
 1.22A 4hvcB-2rf4A:
undetectable		 4hvcB-2rf4A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 146
SER A 156
ALA A 155
PHE A 138
 None
 0.98A 4m93B-2rf4A:
undetectable
4m93C-2rf4A:
undetectable		 4m93B-2rf4A:
18.53
4m93C-2rf4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 THR A  34
GLU A 134
GLY A 135
GLY B  98
PRO B 100
 None
 1.39A 4uinH-2rf4A:
undetectable
4uinL-2rf4A:
undetectable		 4uinH-2rf4A:
20.59
4uinL-2rf4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 THR A  34
GLU A 134
GLY A 135
LEU B  99
PRO B 100
 None
 1.21A 4uinH-2rf4A:
undetectable
4uinL-2rf4A:
undetectable		 4uinH-2rf4A:
20.59
4uinL-2rf4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 133
PHE A 153
VAL A 245
PRO A 127
HIS B  30
 None
 1.17A 5xipA-2rf4A:
undetectable		 5xipA-2rf4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 133
PHE A 153
VAL A 245
PRO A 127
HIS B  30
 None
 1.27A 5xiqA-2rf4A:
undetectable		 5xiqA-2rf4A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 133
PHE A 153
VAL A 245
PRO A 127
HIS B  30
 None
 1.13A 6mn8A-2rf4A:
undetectable		 6mn8A-2rf4A:
19.64