SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rf7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		5 / 12 LEU A 420
LEU A 416
ALA A 357
LEU A 358
ILE A 429
 None
 1.08A 1crbA-2rf7A:
undetectable		 1crbA-2rf7A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		5 / 8 ALA A  80
GLY A 445
PRO A 432
ILE A 434
ILE A  77
 None
 1.35A 1hshD-2rf7A:
undetectable		 1hshD-2rf7A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		5 / 9 LEU A 419
LEU A 420
LEU A 358
GLU A 364
ALA A 362
 None
 1.48A 1sn0A-2rf7A:
undetectable
1sn0C-2rf7A:
undetectable		 1sn0A-2rf7A:
15.24
1sn0C-2rf7A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		4 / 7 TYR A 184
ARG A 182
TYR A 267
PHE A 227
 None
HEC  A   3 ( 4.3A)
None
None
 1.21A 2ajvH-2rf7A:
undetectable
2ajvL-2rf7A:
undetectable		 2ajvH-2rf7A:
17.04
2ajvL-2rf7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		5 / 12 TRP A 270
THR A 281
VAL A 208
PHE A 196
TYR A 267
 HEC  A   4 (-4.1A)
None
None
None
None
 1.45A 2y03B-2rf7A:
2.3		 2y03B-2rf7A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		5 / 12 TRP A 270
THR A 281
VAL A 208
PHE A 196
TYR A 267
 HEC  A   4 (-4.1A)
None
None
None
None
 1.44A 2y04B-2rf7A:
undetectable		 2y04B-2rf7A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		5 / 12 TRP A 270
THR A 281
VAL A 208
PHE A 196
TYR A 267
 HEC  A   4 (-4.1A)
None
None
None
None
 1.47A 3d4sA-2rf7A:
undetectable		 3d4sA-2rf7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		5 / 11 THR A 313
ASP A 300
GLN A  62
SER A 387
THR A  59
 None
None
HEC  A   3 (-3.8A)
None
None
 1.35A 3fsuE-2rf7A:
0.0		 3fsuE-2rf7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		4 / 8 SER A 253
LEU A 446
ALA A 440
ALA A 443
 None
 0.98A 3ns1L-2rf7A:
undetectable		 3ns1L-2rf7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		3 / 3 ASP A 411
THR A 257
PRO A 258
 EDO  A  10 (-3.6A)
None
None
 0.63A 3tkgD-2rf7A:
undetectable		 3tkgD-2rf7A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		4 / 6 CYH A 282
THR A 281
CYH A 209
ILE A 303
 HEC  A   4 (-1.6A)
None
HEC  A   3 (-1.6A)
HEC  A   3 (-4.3A)
 1.15A 3w9tB-2rf7A:
undetectable		 3w9tB-2rf7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		3 / 3 CYH A 314
ASN A 309
LYS A 322
 HEC  A   5 (-1.6A)
EDO  A 480 (-4.7A)
EDO  A 480 (-3.1A)
 1.44A 4k50A-2rf7A:
undetectable		 4k50A-2rf7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		4 / 5 GLY A 108
ALA A 109
GLY A 116
PRO A 117
 None
 0.87A 4u9uA-2rf7A:
undetectable		 4u9uA-2rf7A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		4 / 5 GLY A 108
ALA A 109
GLY A 116
PRO A 117
 None
 0.88A 4u9uB-2rf7A:
undetectable		 4u9uB-2rf7A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		4 / 6 PHE A  84
TRP A  79
SER A  85
GLY A  81
 None
 1.06A 5o4yF-2rf7A:
undetectable		 5o4yF-2rf7A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		3 / 3 LYS A 136
LEU A 133
ARG A 132
 None
 0.79A 5yw0A-2rf7A:
undetectable		 5yw0A-2rf7A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		5 / 12 GLN A  62
HIS A  94
GLY A  93
VAL A  98
ILE A 283
 HEC  A   3 (-3.8A)
HEC  A   3 (-3.3A)
HEC  A   3 (-3.9A)
None
HEC  A   2 (-4.3A)
 1.09A 6c2mB-2rf7A:
undetectable		 6c2mB-2rf7A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 2rf7 CYTOCHROME C-552
(Escherichia
coli) 		5 / 10 PHE A  96
ASP A 162
LEU A 158
GLY A 159
ASN A  42
 None
HEC  A   3 ( 4.1A)
HEC  A   3 (-4.2A)
HEC  A   2 (-3.7A)
None
 1.48A 6r2eC-2rf7A:
undetectable		 6r2eC-2rf7A:
19.69