SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		4 / 6 LEU A 233
ASP A 226
LEU A 258
HIS A 201
 None
 1.15A 1errB-2rfaA:
undetectable		 1errB-2rfaA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		4 / 8 SER A  62
VAL A  97
ASN A  91
ASP A  57
 None
 1.15A 1hwiB-2rfaA:
undetectable		 1hwiB-2rfaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		4 / 8 SER A  62
VAL A  97
ASN A  91
ASP A  57
 None
 1.16A 1hwkA-2rfaA:
undetectable		 1hwkA-2rfaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		4 / 8 SER A  62
VAL A  97
ASN A  91
ASP A  57
 None
 1.16A 1hwkC-2rfaA:
undetectable		 1hwkC-2rfaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		4 / 8 SER A  62
VAL A  97
ASN A  91
ASP A  57
 None
 1.15A 1hwkD-2rfaA:
undetectable		 1hwkD-2rfaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		5 / 11 ALA A 120
ARG A  75
LEU A  50
ALA A  53
LEU A  98
 None
 1.35A 1mjlA-2rfaA:
undetectable
1mjlB-2rfaA:
undetectable		 1mjlA-2rfaA:
16.38
1mjlB-2rfaA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		4 / 8 SER A  62
ALA A  52
ALA A  86
LEU A  83
 None
 0.84A 2bxmA-2rfaA:
undetectable		 2bxmA-2rfaA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		4 / 5 LEU A 233
ASP A 226
LEU A 258
HIS A 201
 None
 1.17A 2jfaA-2rfaA:
undetectable		 2jfaA-2rfaA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		4 / 5 LEU A 233
ASP A 226
LEU A 258
HIS A 201
 None
 1.20A 2qxsA-2rfaA:
undetectable		 2qxsA-2rfaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		4 / 5 LEU A 233
ASP A 226
LEU A 258
HIS A 201
 None
 1.21A 2qxsB-2rfaA:
undetectable		 2qxsB-2rfaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		5 / 12 LEU A  50
ALA A  52
LEU A  65
LEU A  64
LEU A  98
 None
 1.18A 3erdA-2rfaA:
undetectable		 3erdA-2rfaA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		3 / 3 VAL A 173
ALA A 171
PHE A 211
 None
 0.73A 4olbA-2rfaA:
undetectable		 4olbA-2rfaA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		5 / 12 THR A 198
ASP A 193
ASN A 197
LEU A 203
SER A 230
 None
 1.09A 4pooA-2rfaA:
undetectable		 4pooA-2rfaA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		3 / 3 VAL A 173
ALA A 171
PHE A 211
 None
 0.82A 4w5nA-2rfaA:
undetectable		 4w5nA-2rfaA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		5 / 12 LEU A 137
LEU A 132
ALA A 120
VAL A 106
ALA A 141
 None
 0.93A 4x20B-2rfaA:
undetectable		 4x20B-2rfaA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		5 / 11 LEU A  50
ALA A  52
LEU A  65
LEU A  64
LEU A  98
 None
 1.22A 4zn7B-2rfaA:
undetectable		 4zn7B-2rfaA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		4 / 8 ILE A 189
LEU A 219
MET A 215
LEU A 218
 None
 1.08A 5u4sB-2rfaA:
undetectable		 5u4sB-2rfaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Mus
musculus) 		4 / 6 PHE A 152
ALA A 147
SER A 168
ASN A 127
 None
 0.99A 6f88A-2rfaA:
undetectable		 6f88A-2rfaA:
18.10