SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		4 / 7 GLU A 313
LEU A 309
LEU A 120
GLY A 121
 None
HEM  A 410 ( 4.5A)
None
None
 0.84A 1mt1H-2rfbA:
undetectable
1mt1K-2rfbA:
undetectable		 1mt1H-2rfbA:
14.75
1mt1K-2rfbA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		4 / 8 LEU A 309
LEU A 120
GLY A 121
GLU A 313
 HEM  A 410 ( 4.5A)
None
None
None
 0.92A 1n13A-2rfbA:
undetectable
1n13F-2rfbA:
undetectable		 1n13A-2rfbA:
11.66
1n13F-2rfbA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		4 / 6 GLU A 313
LEU A 309
LEU A 120
GLY A 121
 None
HEM  A 410 ( 4.5A)
None
None
 0.87A 1n13H-2rfbA:
undetectable
1n13K-2rfbA:
undetectable		 1n13H-2rfbA:
14.75
1n13K-2rfbA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		4 / 7 LEU A 309
LEU A 120
GLY A 121
GLU A 313
 HEM  A 410 ( 4.5A)
None
None
None
 0.92A 1n13G-2rfbA:
undetectable
1n13J-2rfbA:
undetectable		 1n13G-2rfbA:
11.66
1n13J-2rfbA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 11 ARG A 211
MET A 209
VAL A 231
LEU A 111
ALA A 317
 None
 1.27A 1n4hA-2rfbA:
undetectable		 1n4hA-2rfbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 9 LEU A 205
ALA A 317
ASP A 320
ILE A 115
ILE A 206
 HEM  A 410 ( 4.0A)
None
None
None
None
 0.92A 2idwB-2rfbA:
undetectable		 2idwB-2rfbA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 12 ALA A 108
ALA A 310
PRO A 240
GLY A 198
TYR A 238
 None
HEM  A 410 ( 3.7A)
HEM  A 410 ( 4.2A)
HEM  A 410 (-3.1A)
None
 0.95A 2igtC-2rfbA:
undetectable		 2igtC-2rfbA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		4 / 7 PHE A  75
ILE A  80
ILE A  87
GLY A 197
 None
None
None
HEM  A 410 (-4.3A)
 0.55A 2v0mB-2rfbA:
27.5		 2v0mB-2rfbA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 12 ILE A 115
ASN A 199
PHE A  86
THR A  90
MET A 127
 None
 1.39A 3a8iC-2rfbA:
0.0		 3a8iC-2rfbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		4 / 6 TYR A 107
ALA A 108
LEU A 111
ALA A 314
 None
 0.90A 3b6hB-2rfbA:
7.6		 3b6hB-2rfbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 12 LEU A 205
ALA A 317
ASP A 320
ILE A 115
ILE A 206
 HEM  A 410 ( 4.0A)
None
None
None
None
 0.83A 3bvbB-2rfbA:
undetectable		 3bvbB-2rfbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 10 LEU A 205
ALA A 317
ASP A 320
ILE A 115
ILE A 206
 HEM  A 410 ( 4.0A)
None
None
None
None
 0.88A 3ekvA-2rfbA:
undetectable		 3ekvA-2rfbA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 12 LEU A 295
ARG A 236
TYR A  27
PHE A 280
LEU A  12
 None
 1.18A 3gwuA-2rfbA:
1.5		 3gwuA-2rfbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 10 ILE A 122
PRO A 123
SER A 165
GLY A 121
LEU A 157
 None
 1.38A 3ik6B-2rfbA:
undetectable
3ik6E-2rfbA:
undetectable		 3ik6B-2rfbA:
22.78
3ik6E-2rfbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 10 SER A 163
ILE A 122
PRO A 123
SER A 165
GLY A 121
 None
 1.37A 3ik6B-2rfbA:
undetectable
3ik6E-2rfbA:
undetectable		 3ik6B-2rfbA:
22.78
3ik6E-2rfbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		4 / 7 ILE A 116
LEU A 120
SER A  71
LEU A 172
 None
 0.86A 3r9vA-2rfbA:
1.7
3r9vB-2rfbA:
1.4		 3r9vA-2rfbA:
20.77
3r9vB-2rfbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 11 LEU A 205
ALA A 317
ASP A 320
ILE A 115
ILE A 206
 HEM  A 410 ( 4.0A)
None
None
None
None
 0.89A 3s45B-2rfbA:
undetectable		 3s45B-2rfbA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 12 LEU A 205
ALA A 317
ASP A 320
ILE A 115
ILE A 206
 HEM  A 410 ( 4.0A)
None
None
None
None
 0.85A 3s54B-2rfbA:
undetectable		 3s54B-2rfbA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		4 / 8 PHE A  56
HIS A  64
GLU A  66
ILE A  70
 HEM  A 410 (-4.7A)
HEM  A 410 (-3.9A)
None
None
 1.36A 4cx7A-2rfbA:
undetectable
4cx7B-2rfbA:
undetectable		 4cx7A-2rfbA:
19.48
4cx7B-2rfbA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 12 LEU A 205
ALA A 317
ASP A 320
ILE A 115
ILE A 206
 HEM  A 410 ( 4.0A)
None
None
None
None
 0.82A 4jecA-2rfbA:
undetectable		 4jecA-2rfbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		4 / 6 ILE A 191
ILE A  70
SER A 175
PHE A 161
 None
 0.94A 4m51A-2rfbA:
undetectable		 4m51A-2rfbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		3 / 3 LEU A 132
ASP A 135
TYR A 136
 None
 0.61A 4qc6B-2rfbA:
undetectable		 4qc6B-2rfbA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		4 / 6 ARG A 247
HIS A  64
ARG A  68
ILE A 301
 HEM  A 410 (-3.0A)
HEM  A 410 (-3.9A)
HEM  A 410 (-3.9A)
None
 1.48A 5a06A-2rfbA:
undetectable		 5a06A-2rfbA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		3 / 3 ASP A 276
VAL A  30
LEU A 295
 None
 0.64A 5e5jB-2rfbA:
undetectable		 5e5jB-2rfbA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 12 LEU A 205
ALA A 317
ASP A 320
ILE A 115
ILE A 206
 HEM  A 410 ( 4.0A)
None
None
None
None
 0.83A 5e5kA-2rfbA:
undetectable		 5e5kA-2rfbA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		3 / 3 PRO A 283
ARG A 275
GLU A 277
 None
 0.91A 5j6hA-2rfbA:
undetectable		 5j6hA-2rfbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 10 ILE A 115
ALA A 317
ILE A 316
ILE A 206
TYR A 107
 None
 0.96A 5mvmD-2rfbA:
undetectable
5mvmE-2rfbA:
undetectable		 5mvmD-2rfbA:
13.04
5mvmE-2rfbA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 12 LEU A 205
ALA A 317
ASP A 320
ILE A 115
ILE A 206
 HEM  A 410 ( 4.0A)
None
None
None
None
 0.79A 5t8hA-2rfbA:
undetectable		 5t8hA-2rfbA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 10 LEU A 309
ALA A 310
GLU A 313
ILE A 241
LEU A 235
 HEM  A 410 ( 4.5A)
HEM  A 410 ( 3.7A)
None
HEM  A 410 (-4.5A)
None
 1.33A 6cbzB-2rfbA:
2.6		 6cbzB-2rfbA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		5 / 10 LEU A 318
ALA A 314
LEU A 205
ILE A 104
LEU A 111
 None
None
HEM  A 410 ( 4.0A)
None
None
 1.39A 6cbzB-2rfbA:
2.6		 6cbzB-2rfbA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2rfb CYTOCHROME P450
(Picrophilus
torridus) 		3 / 3 LEU A 309
GLY A 198
PHE A 130
 HEM  A 410 ( 4.5A)
HEM  A 410 (-3.1A)
None
 0.52A 6exiC-2rfbA:
undetectable		 6exiC-2rfbA:
13.99