SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rfg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		5 / 10 ALA A 255
LEU A 242
PHE A 243
ALA A 249
ILE A  10
 None
 1.24A 1g5yC-2rfgA:
undetectable		 1g5yC-2rfgA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		5 / 12 ILE A   7
LEU A   6
ALA A 206
GLY A 214
LEU A 221
 None
 1.01A 2a58A-2rfgA:
undetectable
2a58B-2rfgA:
undetectable		 2a58A-2rfgA:
20.49
2a58B-2rfgA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		5 / 12 ILE A   7
LEU A   6
ALA A 206
GLY A 214
LEU A 221
 None
 1.02A 2a58B-2rfgA:
undetectable
2a58C-2rfgA:
undetectable		 2a58B-2rfgA:
20.49
2a58C-2rfgA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		5 / 12 ILE A   7
LEU A   6
ALA A 206
GLY A 214
LEU A 221
 None
 1.01A 2a58D-2rfgA:
undetectable
2a58E-2rfgA:
undetectable		 2a58D-2rfgA:
20.49
2a58E-2rfgA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		4 / 8 TYR A 132
ASP A 141
GLU A 145
GLU A 172
 None
 1.41A 3dh0A-2rfgA:
undetectable		 3dh0A-2rfgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		4 / 5 TYR A 132
ASP A 141
GLU A 145
GLU A 172
 None
 1.49A 3dh0B-2rfgA:
0.9		 3dh0B-2rfgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		6 / 12 ILE A 202
GLY A 158
ILE A 129
ILE A  73
ASP A 161
LEU A 150
 None
 1.21A 3uj6A-2rfgA:
undetectable		 3uj6A-2rfgA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		5 / 12 ILE A 202
GLY A 158
ILE A 129
ILE A  73
ASP A 161
 None
 0.85A 3uj7A-2rfgA:
undetectable		 3uj7A-2rfgA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		4 / 6 GLY A 104
ALA A 103
TYR A 105
GLU A  83
 None
 0.96A 4ae1A-2rfgA:
undetectable		 4ae1A-2rfgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		4 / 5 HIS A 239
ALA A 236
HIS A 232
TYR A 213
 None
 1.15A 4gboB-2rfgA:
undetectable		 4gboB-2rfgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		5 / 12 LEU A 235
LEU A 287
SER A 205
ILE A 208
LEU A 258
 None
 1.04A 4ky8A-2rfgA:
undetectable		 4ky8A-2rfgA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		5 / 12 LEU A 235
LEU A 287
SER A 205
ILE A 208
LEU A 258
 None
 1.11A 4ky8C-2rfgA:
undetectable		 4ky8C-2rfgA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		5 / 12 LEU A 235
LEU A 287
SER A 205
ILE A 208
LEU A 258
 None
 1.03A 4ky8E-2rfgA:
undetectable		 4ky8E-2rfgA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		5 / 12 LEU A 183
GLY A 200
GLN A 199
LEU A 221
MET A   1
 None
 1.45A 4ojbA-2rfgA:
undetectable		 4ojbA-2rfgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 2rfg DIHYDRODIPICOLINATE
SYNTHASE
(Hahella
chejuensis) 		4 / 5 GLY A   4
LEU A   6
SER A 181
GLN A 199
 None
 1.30A 6ji6A-2rfgA:
undetectable		 6ji6A-2rfgA:
20.77