SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rfl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2rfl PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE SIXA
(Agrobacterium
fabrum) 		5 / 12 GLU A 127
GLY A 126
ARG A 158
ASP A 128
ALA A 133
 None
 1.19A 2br4B-2rflA:
3.1		 2br4B-2rflA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2rfl PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE SIXA
(Agrobacterium
fabrum) 		4 / 6 LEU A  55
MET A 117
MET A 124
LEU A  11
 None
 1.18A 2oz7A-2rflA:
undetectable		 2oz7A-2rflA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 2rfl PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE SIXA
(Agrobacterium
fabrum) 		5 / 10 ALA A  74
ALA A  70
THR A  67
LEU A  12
VAL A 111
 None
 1.41A 2wuzB-2rflA:
undetectable		 2wuzB-2rflA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 2rfl PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE SIXA
(Agrobacterium
fabrum) 		5 / 11 PHE A  75
ARG A  52
PRO A  53
ILE A  56
MET A 109
 None
 1.41A 6fgcA-2rflA:
2.2		 6fgcA-2rflA:
20.69